Year 2017, Volume 18, Issue 1, Pages 7 - 12 2017-01-17

ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Ömer ATEŞ [1]

102 184

AMAÇ: Alopesi Areata patogenezinde, değiş- miş T hücre aracılı bağışıklığın rol aldığını gösteren çok sayıda çalışma bulunmaktadır. Sitokinlerin ve kemokinlerin Alopesi Areata’nın immun sürecinde önemli rol oynamasından dolayı, Alopesi Areata’ya yatkınlık ile TNF-α-308G/A polimorfizmi arasındaki olası bağlantının Türk populasyonunda araştırılması amacıyla bu çalışma gerçekleştirildi.

GEREÇ VE YÖNTEM: Sunulan vaka kontrol çalışmasına 107 Alopesi Areata hastası ve 113 sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A polimorfizminin genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.

BULGULAR: Hasta ve kontrol gruplarında TNF-α-308 G/A genotiplerinin ve allel frekanslarının dağılımı arasında anlamlı bir bağlantı bulunamadı (p=0.673 ve p=0.177, sırasıyla). Benzer şekilde, TNF-α-308 G/A polimorfizmi ile Alopesi Areata’nın klinik bulguları arasında fark tespit edilemedi.

SONUÇ: Bu çalışma, TNF-α-308 G/A polimorfizminin Türk populasyonunda Alopesi Areata gelişiminde önemli bir rol oynamadığını göstermektedir. 

Alopesi Areata, Polimorfizm, Genetik yatkınlık, TNF-α
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Subjects Health Care Sciences and Services
Journal Section Articles
Authors

Author: Ömer ATEŞ

Bibtex @research article { kocatepetip343171, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2017}, volume = {18}, pages = {7 - 12}, doi = {10.18229/kocatepetip.343171}, title = {ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ}, key = {cite}, author = {ATEŞ, Ömer} }
APA ATEŞ, Ö . (2017). ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Kocatepe Tıp Dergisi, 18 (1), 7-12. DOI: 10.18229/kocatepetip.343171
MLA ATEŞ, Ö . "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ". Kocatepe Tıp Dergisi 18 (2017): 7-12 <http://dergipark.org.tr/kocatepetip/issue/29800/343171>
Chicago ATEŞ, Ö . "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ". Kocatepe Tıp Dergisi 18 (2017): 7-12
RIS TY - JOUR T1 - ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ AU - Ömer ATEŞ Y1 - 2017 PY - 2017 N1 - doi: 10.18229/kocatepetip.343171 DO - 10.18229/kocatepetip.343171 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 7 EP - 12 VL - 18 IS - 1 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.343171 UR - https://doi.org/10.18229/kocatepetip.343171 Y2 - 2016 ER -
EndNote %0 Kocatepe Medical Journal ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ %A Ömer ATEŞ %T ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ %D 2017 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 18 %N 1 %R doi: 10.18229/kocatepetip.343171 %U 10.18229/kocatepetip.343171
ISNAD ATEŞ, Ömer . "ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ". Kocatepe Tıp Dergisi 18 / 1 (January 2017): 7-12. https://doi.org/10.18229/kocatepetip.343171