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ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ

Yıl 2017, Cilt: 18 Sayı: 1, 7 - 12, 17.01.2017
https://doi.org/10.18229/kocatepetip.343171

Öz

AMAÇ: Alopesi Areata patogenezinde, değiş-
miş T hücre aracılı bağışıklığın rol aldığını gösteren
çok sayıda çalışma bulunmaktadır. Sitokinlerin
ve kemokinlerin Alopesi Areata’nın immun
sürecinde önemli rol oynamasından dolayı, Alopesi
Areata’ya yatkınlık ile TNF-α-308G/A polimorfizmi
arasındaki olası bağlantının Türk populasyonunda
araştırılması amacıyla bu çalışma
gerçekleştirildi.

GEREÇ VE YÖNTEM: Sunulan vaka kontrol çalışmasına
107 Alopesi Areata hastası ve 113
sağlıklı kontrol bireyi dahil edildi. TNF-α-308G/A
polimorfizminin genotiplendirmesi Polimeraz
Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim
Analizi (REA) yöntemleri ile gerçekleştirildi.

BULGULAR: Hasta ve kontrol gruplarında
TNF-α-308 G/A genotiplerinin ve allel frekanslarının
dağılımı arasında anlamlı bir bağlantı
bulunamadı (p=0.673 ve p=0.177, sırasıyla).
Benzer şekilde, TNF-α-308 G/A polimorfizmi ile
Alopesi Areata’nın klinik bulguları arasında fark
tespit edilemedi.

SONUÇ: Bu çalışma, TNF-α-308 G/A polimorfizminin
Türk populasyonunda Alopesi Areata
gelişiminde önemli bir rol oynamadığını göstermektedir. 

Kaynakça

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Toplam 34 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Ömer Ateş

Yayımlanma Tarihi 17 Ocak 2017
Kabul Tarihi 14 Nisan 2016
Yayımlandığı Sayı Yıl 2017 Cilt: 18 Sayı: 1

Kaynak Göster

APA Ateş, Ö. (2017). ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Kocatepe Tıp Dergisi, 18(1), 7-12. https://doi.org/10.18229/kocatepetip.343171
AMA Ateş Ö. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. Ocak 2017;18(1):7-12. doi:10.18229/kocatepetip.343171
Chicago Ateş, Ömer. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi 18, sy. 1 (Ocak 2017): 7-12. https://doi.org/10.18229/kocatepetip.343171.
EndNote Ateş Ö (01 Ocak 2017) ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. Kocatepe Tıp Dergisi 18 1 7–12.
IEEE Ö. Ateş, “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”, KTD, c. 18, sy. 1, ss. 7–12, 2017, doi: 10.18229/kocatepetip.343171.
ISNAD Ateş, Ömer. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi 18/1 (Ocak 2017), 7-12. https://doi.org/10.18229/kocatepetip.343171.
JAMA Ateş Ö. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. 2017;18:7–12.
MLA Ateş, Ömer. “ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ”. Kocatepe Tıp Dergisi, c. 18, sy. 1, 2017, ss. 7-12, doi:10.18229/kocatepetip.343171.
Vancouver Ateş Ö. ALOPESİ AREATA’DA TNF-α PROMOTÖR POLİMORFİZMİNİN ANALİZİ. KTD. 2017;18(1):7-12.

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