Year 2019, Volume 11, Issue 1, Pages 55 - 61 2019-03-25

Clinical Markers of Clopidogrel Resistance in Percutaneous Coronary-Treated Patients
Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri

Cem Özde [1] , Osman Kayapinar [2]

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Abstart
Objective: Antiplatelet therapy is an indispensable part of current coronary artery disease and resistance to ADP inhibitors leads to adverse cardiovascular events in patients. In this study, it was aimed to detect clopidogrel resistance markers in patients undergoing percutaneous coronary intervention.

METHODS: Eighty consecutive patients (38 clopidogrel resistance, 42 controls) who underwent percutan intervention procedure due to coronary artery disease and who had tested positive for clopidogrel resistance at the end of the first week were included in the study. In the VerifyNow test,> 208 platelet reactivity unit clopidogrel resistance and> 550 aspirin reaction unit were accepted as aspirin resistance. 28 patients were treated with ST elevation MI, 18 patients without ST elevation MI, and the other patients were treated for stable coronary disease. Demographic findings, CV and family background variables, body mass index, injection fraction, aspirin resistance and biochemical parameters were compared.

Findings: The mean age of the patients was 59 ± 12 and 15 were female. Subjects with clopidogrel resistance were significantly lower in Hemoglobin values. Resistance was more frequent in hypertension, while female sex and smokers were more frequent. Logistic regression analysis showed that hemoglobin (odds ratio = 0.8; 95% safety interval (0.678-0.945), p = 0.008] significantly predicted clopidogrel resistance.

Conclusion: Low hemoglobin level predicts clopidogrel resistance independently of other clinical variables

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Primary Language tr
Subjects Health Care Sciences and Services
Published Date Mart 2019
Journal Section Articles
Authors

Author: Cem Özde
Institution: DÜZCE ÜNİVERSİTESİ, TIP FAKÜLTESİ
Country: Turkey


Author: Osman Kayapinar (Primary Author)
Country: Turkey


Bibtex @research article { ktd444477, journal = {Konuralp Medical Journal}, issn = {1309-3878}, eissn = {1309-3878}, address = {Duzce University}, year = {2019}, volume = {11}, pages = {55 - 61}, doi = {10.18521/ktd.444477}, title = {Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri}, key = {cite}, author = {Özde, Cem and Kayapinar, Osman} }
APA Özde, C , Kayapinar, O . (2019). Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri. Konuralp Medical Journal, 11 (1), 55-61. DOI: 10.18521/ktd.444477
MLA Özde, C , Kayapinar, O . "Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri". Konuralp Medical Journal 11 (2019): 55-61 <http://dergipark.org.tr/ktd/issue/44366/444477>
Chicago Özde, C , Kayapinar, O . "Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri". Konuralp Medical Journal 11 (2019): 55-61
RIS TY - JOUR T1 - Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri AU - Cem Özde , Osman Kayapinar Y1 - 2019 PY - 2019 N1 - doi: 10.18521/ktd.444477 DO - 10.18521/ktd.444477 T2 - Konuralp Medical Journal JF - Journal JO - JOR SP - 55 EP - 61 VL - 11 IS - 1 SN - 1309-3878-1309-3878 M3 - doi: 10.18521/ktd.444477 UR - https://doi.org/10.18521/ktd.444477 Y2 - 2019 ER -
EndNote %0 Konuralp Medical Journal Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri %A Cem Özde , Osman Kayapinar %T Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri %D 2019 %J Konuralp Medical Journal %P 1309-3878-1309-3878 %V 11 %N 1 %R doi: 10.18521/ktd.444477 %U 10.18521/ktd.444477
ISNAD Özde, Cem , Kayapinar, Osman . "Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri". Konuralp Medical Journal 11 / 1 (March 2019): 55-61. https://doi.org/10.18521/ktd.444477