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APTAMER BASED IDENTIFICATION METHOD AND ITS APPLICATIONS IN FOOD SAFETY

Yıl 2024, Cilt: 49 Sayı: 3, 536 - 553, 15.06.2024

Melike Canpolat , Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Öz

Aptamers are single-stranded, short, synthetic nucleic acid sequences. Aptamers, which show high affinity and specific binding to various target molecules, are used for the sensitive detection of various risk factors such as pathogenic microorganisms, biotoxins, allergens, pesticides and heavy metals that may be present in foods. The selection of aptamers specifically binding to molecules that pose a risk in terms of food safety is carried out through a process called SELEX. The selected aptamer interacts specifically with the target molecule and this interaction is measured using electrochemical, optical, or other biosensor techniques. There is a growing interest in aptamer-based methods with high specificity and sensitivity, which provide faster results compared to conventional methods used in food analysis. This review summarized the general properties of aptamers and their production by the SELEX principle and given examples of their applications in food safety.

Anahtar Kelimeler

Aptamer SELEX biosensor biomarker molecule contamination food safety

Kaynakça

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APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI

Yıl 2024, Cilt: 49 Sayı: 3, 536 - 553, 15.06.2024

Melike Canpolat , Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Öz

Aptamerler, tek sarmallı, kısa, sentetik nükleik asit dizileridir. Çeşitli hedef moleküllere karşı yüksek afinite gösteren ve spesifik olarak bağlanan aptamerler, gıdalarda bulunabilecek patojen mikroorganizmalar, biyotoksinler, alerjenler, pestisitler ve ağır metaller gibi çeşitli risk faktörlerinin hassas bir şekilde tespiti için kullanılmaktadır. Gıda güvenliği açısından risk oluşturan moleküllere spesifik olarak bağlanan aptamerlerin seçilmesi SELEX adı verilen bir süreçle gerçekleştirilir. Seçilen aptamer, hedef molekül ile özgün olarak etkileşime girer ve bu etkileşim elektrokimyasal, optik veya diğer biyosensör teknikler kullanılarak ölçülür. Gıda analizlerinde kullanılan geleneksel yöntemlere kıyasla daha hızlı sonuçlar veren, yüksek özgüllüğe ve duyarlılığa sahip aptamer tabanlı yöntemlere duyulan ilgi giderek artmaktadır. Bu derlemede aptamerlerin genel özellikleri ve SELEX prensibiyle üretimleri özetlenmiş ve gıda güvenliği alanındaki uygulamalarına örnekler verilmiştir.

Anahtar Kelimeler

Aptamer SELEX biyobelirteç molekülü biyosensör kontaminasyon gıda güvenliği

Kaynakça

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  • Shen, Z., Xu, D., Wang, G., Geng, L., Xu, R., Wang, G., Sun, X. (2022). Novel colorimetric aptasensor based on MOF-derived materials and its applications for organophosphorus pesticides determination. Journal of Hazardous Materials, 440, 129707. https://doi.org/10.1016/ j.jhazmat.2022.129707
  • Sola, M., Menon, A. P., Moreno, B., Meraviglia-Crivelli, D., Soldevilla, M. M., Cartón García, F., Pastor, F. (2020). Aptamers against live targets: is in vivo SELEX finally coming to the edge? Molecular Therapy-Nucleic Acids, 21, 192-204. https://doi.org/10.1016/j.omtn.2020.05.025
  • Srinivasan, S., Ranganathan, V., McConnell, E. M., Murari, B. M., DeRosa, M. C. (2023). Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium (i) and lead (ii). RSC advances, 13(29), 20040-20049. https://10.1039/d3ra01658g
  • Su, L., Wang, S., Wang, L., Yan, Z., Yi, H., Zhang, D., Ma, Y. (2020). Fluorescent aptasensor for carbendazim detection in aqueous samples based on gold nanoparticles quenching Rhodamine B. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 225, 117511. https://doi.org/10.1016/j.saa.2019.117511
  • Sun, J., Liu, W., He, Z., Li, B., Dong, H., Liu, M., Sun, X. (2024). Novel electrochemiluminescence aptasensor based on AuNPs-ABEI encapsulated TiO2 nanorod for the detection of acetamiprid residues in vegetables. Talanta, 269, 125471. https://doi.org/10.1016/j.talanta.2023.125471
  • Sun, C., Su, R., Bie, J., Sun, H., Qiao, S., Ma, X., Zhang, T. (2018). Label-free fluorescent sensor based on aptamer and thiazole orange for the detection of tetracycline. Dyes and Pigments, 149, 867-875. https://doi.org/10.1016/ j.dyepig.2017.11.031
  • Svigelj, R., Dossi, N., Pizzolato, S., Toniolo, R., Miranda-Castro, R., de-Los-Santos-Álvarez, N., Lobo-Castañón, M. J. (2020). Truncated aptamers as selective receptors in a gluten sensor supporting direct measurement in a deep eutectic solvent. Biosensors and Bioelectronics, 165, 112339. https://doi.org/10.1016/j.bios.2020.112339
  • Tang, X., Zuo, J., Yang, C., Jiang, J., Zhang, Q., Ping, J., Li, P. (2023a). Current trends in biosensors for biotoxins (mycotoxins, marine toxins, and bacterial food toxins): principles, application, and perspective. TrAC Trends in Analytical Chemistry, 117144. https://doi.org/ 10.1016/j.trac.2023.117144
  • Tang, Y., Yuan, J., Zhang, Y., Khan, I. M., Ma, P., Wang, Z. (2023b). Lateral flow assays based on aptamers for food safety applications. Food Control, 110051. https://doi.org/10.1016/ j.foodcont.2023.110051
  • Teng, Y., Liu, S., Yang, S., Guo, X., Zhang, Y., Song, Y., Cui, Y. (2019). Computer-designed orthogonal RNA aptamers programmed to recognize Ebola virus glycoproteins. Biosafety and Health, 1(2), 105-111. https://doi.org/ 10.1016/j.bsheal.2019.11.001
  • Torregrosa, D., Jauset-Rubio, M., Serrano, R., Svobodová, M., Grindlay, G., O'Sullivan, C. K., Mora, J. (2023). Ultrasensitive determination of β-conglutin food allergen by means an aptamer assay based on inductively coupled plasma mass spectrometry detection. Analytica Chimica Acta, 1252, 341042. https://doi.org/10.1016/ j.aca.2023.341042
  • Uğurlu, Ö., Man, E., Gök, O., Ülker, G., Soytürk, H., Özyurt, C., Evran, S. (2023). A review of aptamer-conjugated nanomaterials for analytical sample preparation: Classification according to the utilized nanomaterials. Analytica Chimica Acta, 342001. https://doi.org/10.1016/ j.aca.2023.342001
  • Verdian, A., Fooladi, E., Rouhbakhsh, Z. (2019). Recent progress in the development of recognition bioelements for polychlorinated biphenyls detection: Antibodies and aptamers. Talanta, 202, 123-135. https://doi.org/ 10.1016/j.talanta.2019.04.059
  • Wang, B., Kobeissy, F., Golpich, M., Cai, G., Li, X., Abedi, R., Wang, K. K. (2024). Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Molecules, 29(5), 1124. https://doi.org/ 10.3390/molecules29051124
  • Wang, L., Liu, G., Ren, Y., Feng, Y., Zhao, X., Zhu, Y., Chen, X. (2020). Integrating target-triggered aptamer-capped HRP@ metal–organic frameworks with a colorimeter readout for on-site sensitive detection of antibiotics. Analytical Chemistry, 92(20), 14259-14266. https://doi.org/ 10.1021/acs.analchem.0c03723
  • Wang, J., Chen, D., Huang, W., Yang, N., Yuan, Q., Yang, Y. (2023a). Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring. In Exploration, 3 (3), p. 20210027. https://doi.org/ 10.1002/EXP.20210027
  • Wang, T., Chen, C., Larcher, L. M., Barrero, R. A., Veedu, R. N. (2019). Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development. Biotechnology advances, 37(1), 28-50. https://doi.org/10.1016/j.biotechadv.2018.11.001
  • Wang, Y., He, D., Du, Z., Xu, E., Jin, Z., Wu, Z., Cui, B. (2022). Ultrasensitive Detection of Staphylococcal Enterotoxin B with an AuNPs@ MIL-101 Nanohybrid-Based Dual-Modal Aptasensor. Food Analytical Methods, 15, 1368–1376. https://doi.org/10.1007/s12161-021-02204-z
  • Wang, Y. L., Zeng, G. C., Lee, C. T., Lin, C. K., Kuo, T. H., Paulose, A. K., Hung, S. C. (2023b). Fabrication of Aptamer-based Field Effect Transistor Sensors for Detecting Mercury Ions. ECS Transactions, 111(3), 63. https://doi.org/10.1149/11103.0063ecst
  • Wei, W., Lin, H., Hao, T., Wang, S., Hu, Y., Guo, Z., Luo, X. (2021). DNA walker-mediated biosensor for target-triggered triple-mode detection of Vibrio parahaemolyticus. Biosensors and Bioelectronics, 186, 113305. https://doi.org/ 10.1016/j.bios.2021.113305
  • Wei, X., Ma, P., Mahmood, K. I., Zhang, Y., Wang, Z. (2023). A review: Construction of aptamer screening methods based on improving the screening rate of key steps. Talanta, 253, 124003. https://doi.org/10.1016/ j.talanta.2022.124003,
  • Wei, S., Su, Z., Bu, X., Shi, X., Pang, B., Zhang, L., Zhao, C. (2022). On-site colorimetric detection of Salmonella typhimurium. Science of Food, 6(1), 48. https://doi.org/10.1038/s41538-022-00164-0
  • Wolter, O., Mayer, G. (2017). Aptamers as valuable molecular tools in neurosciences. Journal of Neuroscience, 37(10), 2517-2523. https://doi.org/10.1523/JNEUROSCI.1969-16.2017
  • Xie, M., Zhao, F., Zhang, Y., Xiong, Y., Han, S. (2022). Recent advances in aptamer-based optical and electrochemical biosensors for detection of pesticides and veterinary drugs. Food Control, 131, 108399. https://doi.org/10.1016/ j.foodcont.2021.108399
  • Xu, Y., Cheng, N., Luo, Y., Huang, K., Chang, Q., Pang, G., Xu, W. (2022). An Exo III-assisted catalytic hairpin assembly-based self-fluorescence aptasensor for pesticide detection. Sensors and Actuators B: Chemical, 358, 131441. https://doi.org/10.1016/j.snb.2022.131441
  • Yadav, R., Berlina, A. N., Zherdev, A. V., Gaur, M. S., Dzantiev, B. B. (2020). Rapid and selective electrochemical detection of pb 2+ ions using aptamer-conjugated alloy nanoparticles. SN Applied Sciences, 2, 1-11. https://doi.org/ 10.1007/s42452-020-03840-6
  • Yalagandula, B. P., Mohanty, S., Goswami, P. P., Singh, S. G. (2024). Optimizations towards a nearly invariable WO3-functionalized electrochemical aptasensor for ultra-trace identification of arsenic in lake water. Sensors and Actuators B: Chemical, 398, 134730. https://doi.org/10.1016/j.snb.2023.134730
  • Yan, M., Wang, H., Li, M., Zhang, W., Du, H., Chen, Z., She, Y. (2023). Multicolor aptasensors for pesticide multiresidues detection in agricultural products using bioorthogonal surface-enhanced Raman scattering tags. Talanta, 265, 124800. https://doi.org/10.1016/ j.talanta.2023.124800
  • Yang, S., Li, C., Zhan, H., Liu, R., Chen, W., Wang, X., Xu, K. (2023). A label-free fluorescent biosensor based on specific aptamer-templated silver nanoclusters for the detection of tetracycline. Journal of Nanobiotechnology, 21(1), 22. https://doi.org/10.1186/s12951-023-01785-7
  • Yao, X., Shen, J., Liu, Q., Fa, H., Yang, M., Hou, C. (2020). A novel electrochemical aptasensor for the sensitive detection of kanamycin based on UiO-66-NH 2/MCA/MWCNT@ rGONR nanocomposites. Analytical Methods, 12(41), 4967-4976. https://doi.org/10.1039/D0AY01503B
  • Yu, H., Zhao, Q. (2022). Aptamer molecular beacon sensor for rapid and sensitive detection of ochratoxin A. Molecules, 27(23), 8267. https://doi.org/10.3390/molecules27238267
  • Yu, H., Zhao, Q. (2024). Sensitive electrochemical sensor for Cd2+ with engineered short high-affinity aptamer undergoing large conformation change. Talanta, 271, 125642.https://doi.org/10.1016/j.talanta.2024.125642
  • Zhang, H. L., Lv, C., Li, Z. H., Jiang, S., Cai, D., Liu, S. S., Zhang, K. H. (2023a). Analysis of aptamer-target binding and molecular mechanisms by thermofluorimetric analysis and molecular dynamics simulation. Frontiers in Chemistry, 11, 1144347. https://doi.org/10.3389/ fchem.2023.1144347
  • Zhang, J., Liu, X., Shi, W., Wei, Y., Wu, Z., Li, J., Xu, K. (2022). Rapid and sensitive detection of Escherichia coli O157: H7 based on silver nanocluster fluorescent probe. Journal of the Iranian Chemical Society, 19(4), 1339-1346. https://doi.org/10.1007/s13738-021-02384-9
  • Zhang, N., Chen, Z., Liu, D., Jiang, H., Zhang, Z. K., Lu, A., Zhang, G. (2021a). Structural biology for the molecular insight between aptamers and target proteins. International Journal of Molecular Sciences, 22(8), 4093. https://doi.org/ 10.3390/ijms22084093
  • Zhang, N., Lv, H., Wang, J., Yang, Z., Ding, Y., Zhao, B., Tian, Y. (2023b). An aptamer-based colorimetric/SERS dual-mode sensing strategy for the detection of sulfadimethoxine residues in animal-derived foods. Analytical Methods, 15(8), 1047-1053. https://doi.org/10.1039/d2ay01825j
  • Zhang, W., Wang, Y., Nan, M., Li, Y., Yun, J., Wang, Y., Bi, Y. (2021b). Novel colorimetric aptasensor based on unmodified gold nanoparticle and ssDNA for rapid and sensitive detection of T-2 toxin. Food Chemistry, 348, 129128. https://doi.org/10.1016/ j.foodchem.2021.129128
  • Zhao, L., Li, L., Zhao, Y., Zhu, C., Yang, R., Fang, M., Luan, Y. (2023). Aptamer-based point-of-care-testing for small molecule targets: From aptamers to aptasensors, devices and applications. TrAC Trends in Analytical Chemistry, 117408. https://doi.org/10.1016/j.trac.2023.117408
  • Zheng, Y., Shi, Z., Wu, W., He, C., Zhang, H. (2021). Label-free DNA electrochemical aptasensor for fumonisin B 1 detection in maize based on graphene and gold nanocomposite. Journal of Analytical Chemistry, 76, 252-257. https://doi.org/10.1134/S1061934821020167
  • Zhong, Z., Gao, R., Chen, Q., Jia, L. (2020). Dual-aptamers labeled polydopamine-polyethyleneimine copolymer dots assisted engineering a fluorescence biosensor for sensitive detection of Pseudomonas aeruginosa in food samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 224, 117417. https://doi.org/10.1016/j.saa.2019.117417
  • Zhou, E., Li, Q., Zhu, D., Chen, G., Wu, L. (2024a). Characterization of physicochemical and immunogenic properties of allergenic proteins altered by food processing: a review. Food Science and Human Wellness, 13(3), 1135-1151. https://doi.org/10.26599/FSHW.2022.9250095
  • Zhou, J., Zhang, C., Hu, C., Li, S., Liu, Y., Chen, Z., Deng, Y. (2024b). Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg2+. Chinese Chemical Letters, 109561. https://doi.org/10.1016/j.cclet.2024.109561
  • Zhou, Y., Mahapatra, C., Chen, H., Peng, X., Ramakrishna, S., Nanda, H. S. (2020). Recent developments in fluorescent aptasensors for detection of antibiotics. Current Opinion in Biomedical Engineering, 13, 16-24. https://doi.org/ 10.1016/j.cobme.2019.08.003
  • Zhu, C., Feng, Z., Qin, H., Chen, L., Yan, M., Li, L., Qu, F. (2023). Recent progress of SELEX methods for screening nucleic acid aptamers. Talanta, 124998. https://doi.org/10.1016/ j.talanta.2023.124998
  • Zou, XM., Zou, J., Song, S., Guan-Hua, C. (2019). Screening of oligonucleotide aptamers and application in detection of pesticide and veterinary drug residues. Chinese Journal of Analytical Chemistry. Chinese Journal of Analytical Chemistry, 47(4), 488-499. https://doi.org/ 10.1016/S1872-2040(19)61153-9
Toplam 106 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Biyoteknolojisi
Bölüm Makaleler
Yazarlar

Melike Canpolat 0000-0003-0345-465X

Zülal Kesmen 0000-0002-4505-6871

Yayımlanma Tarihi 15 Haziran 2024
Gönderilme Tarihi 26 Aralık 2023
Kabul Tarihi 30 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 49 Sayı: 3

Kaynak Göster

APA Canpolat, M., & Kesmen, Z. (2024). APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda, 49(3), 536-553. https://doi.org/10.15237/gida.GD23145
AMA Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. Haziran 2024;49(3):536-553. doi:10.15237/gida.GD23145
Chicago Canpolat, Melike, ve Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49, sy. 3 (Haziran 2024): 536-53. https://doi.org/10.15237/gida.GD23145.
EndNote Canpolat M, Kesmen Z (01 Haziran 2024) APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda 49 3 536–553.
IEEE M. Canpolat ve Z. Kesmen, “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”, GIDA, c. 49, sy. 3, ss. 536–553, 2024, doi: 10.15237/gida.GD23145.
ISNAD Canpolat, Melike - Kesmen, Zülal. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49/3 (Haziran 2024), 536-553. https://doi.org/10.15237/gida.GD23145.
JAMA Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. 2024;49:536–553.
MLA Canpolat, Melike ve Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda, c. 49, sy. 3, 2024, ss. 536-53, doi:10.15237/gida.GD23145.
Vancouver Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. 2024;49(3):536-53.
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