Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Cihan Gür; Fatih Kandemir; Aydın Genç

doi:10.46810/tdfd.809220

Araştırma Makalesi

Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Yıl 2020, Cilt: 9 Sayı: 2, 118 - 126, 30.12.2020

Cihan Gür Fatih Kandemir Aydın Genç

https://doi.org/10.46810/tdfd.809220

Cited By: 7

Öz

Bortezomib (BTZ), proteazom sistemini bloke ederek hücresel protein yıkımını engelleyen yeni nesil bir antineoplastik ilaçtır. Bu çalışmada BTZ kaynaklı kalp hasarına karşı bir izokinolin alkaloid olan berberinin (BBR) koruyucu etkileri araştırılmıştır. Çalışmada erkek Sprague Dawley cinsi ratlara 1., 3., 5. ve 7. günlerde periton içi 0,2 mg kg-1 BTZ ve 10 gün boyunca her gün 50 ve 100 mg kg-1 dozlarda BBR verildi. Ratların kalp dokularında malondialdehit (MDA), glutatyon (GSH), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve nitrik oksit (NO) seviyeleri ile süperoksit dismutaz (SOD), katalaz (KAT), glutatyon peroksidaz (GPx) ve laktat dehidrogenaz (LDH) aktiviteleri biyokimyasal yöntemler ile analiz edildi. Veriler BTZ’nin kalp dokusunda MDA, NO ve TOK seviyelerini, serumda LDH aktivelerini ve oksidatif stres indeksini (OSI) önemli ölçüde arttırdığını, GSH ve TAK seviyeleri ile SOD, KAT ve GPx aktivitelerini azaltarak oksidatif stresi tetiklediğini buna bağlı olarak dokuda hasar oluşturduğunu gösterdi. Buna karşın BBR, BTZ’nin neden olduğu oksidatif stresi ve nitrozatif stresi hafifleterek kalp hasarına karşı koruyucu etki gösterdi. Sonuçlara göre BBR’nin, BTZ ile indüklenen kardiyak toksisiteye karşı daha ileri çalışmalardan sonra koruyucu olarak kullanılabileceğini gösterdi.

Anahtar Kelimeler

Berberin, Bortezomib, Kalp, Nitrozatif Stres, Oksidatif Stres

Kaynakça

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Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Veteriner Cerrahi
Bölüm	Makaleler
Yazarlar	Cihan Gür 0000-0001-6775-7858 Fatih Kandemir 0000-0002-8490-2479 Aydın Genç Bu kişi benim 0000-0001-5367-0743
Yayımlanma Tarihi	30 Aralık 2020
Yayımlandığı Sayı	Yıl 2020 Cilt: 9 Sayı: 2

Kaynak Göster

APA	Gür, C., Kandemir, F., & Genç, A. (2020). Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa Ve Fen Dergisi, 9(2), 118-126. https://doi.org/10.46810/tdfd.809220
AMA	Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. Aralık 2020;9(2):118-126. doi:10.46810/tdfd.809220
Chicago	Gür, Cihan, Fatih Kandemir, ve Aydın Genç. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi 9, sy. 2 (Aralık 2020): 118-26. https://doi.org/10.46810/tdfd.809220.
EndNote	Gür C, Kandemir F, Genç A (01 Aralık 2020) Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa ve Fen Dergisi 9 2 118–126.
IEEE	C. Gür, F. Kandemir, ve A. Genç, “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”, TDFD, c. 9, sy. 2, ss. 118–126, 2020, doi: 10.46810/tdfd.809220.
ISNAD	Gür, Cihan vd. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi 9/2 (Aralık 2020), 118-126. https://doi.org/10.46810/tdfd.809220.
JAMA	Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. 2020;9:118–126.
MLA	Gür, Cihan vd. “Bortezomib Ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif Ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa Ve Fen Dergisi, c. 9, sy. 2, 2020, ss. 118-26, doi:10.46810/tdfd.809220.
Vancouver	Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. 2020;9(2):118-26.