Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Cihan Gür; Fatih Kandemir; Aydın Genç

doi:10.46810/tdfd.809220

Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi

Öz

Bortezomib (BTZ), proteazom sistemini bloke ederek hücresel protein yıkımını engelleyen yeni nesil bir antineoplastik ilaçtır. Bu çalışmada BTZ kaynaklı kalp hasarına karşı bir izokinolin alkaloid olan berberinin (BBR) koruyucu etkileri araştırılmıştır. Çalışmada erkek Sprague Dawley cinsi ratlara 1., 3., 5. ve 7. günlerde periton içi 0,2 mg kg-1 BTZ ve 10 gün boyunca her gün 50 ve 100 mg kg-1 dozlarda BBR verildi. Ratların kalp dokularında malondialdehit (MDA), glutatyon (GSH), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve nitrik oksit (NO) seviyeleri ile süperoksit dismutaz (SOD), katalaz (KAT), glutatyon peroksidaz (GPx) ve laktat dehidrogenaz (LDH) aktiviteleri biyokimyasal yöntemler ile analiz edildi. Veriler BTZ’nin kalp dokusunda MDA, NO ve TOK seviyelerini, serumda LDH aktivelerini ve oksidatif stres indeksini (OSI) önemli ölçüde arttırdığını, GSH ve TAK seviyeleri ile SOD, KAT ve GPx aktivitelerini azaltarak oksidatif stresi tetiklediğini buna bağlı olarak dokuda hasar oluşturduğunu gösterdi. Buna karşın BBR, BTZ’nin neden olduğu oksidatif stresi ve nitrozatif stresi hafifleterek kalp hasarına karşı koruyucu etki gösterdi. Sonuçlara göre BBR’nin, BTZ ile indüklenen kardiyak toksisiteye karşı daha ileri çalışmalardan sonra koruyucu olarak kullanılabileceğini gösterdi.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Veteriner Cerrahi

Bölüm

Araştırma Makalesi

Yazarlar

Cihan Gür ^*
0000-0001-6775-7858
Türkiye

Fatih Kandemir
0000-0002-8490-2479
Türkiye

Aydın Genç Bu kişi benim
0000-0001-5367-0743
Türkiye

Yayımlanma Tarihi

30 Aralık 2020

Gönderilme Tarihi

12 Ekim 2020

Kabul Tarihi

14 Aralık 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 9 Sayı: 2

DOI

https://doi.org/10.46810/tdfd.809220

IZ

https://izlik.org/JA58TD65ZT

Kaynak Göster

RIS / Bibtex

APA

Gür, C., Kandemir, F., & Genç, A. (2020). Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa ve Fen Dergisi, 9(2), 118-126. https://doi.org/10.46810/tdfd.809220

AMA

1.Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. 2020;9(2):118-126. doi:10.46810/tdfd.809220

Chicago

Gür, Cihan, Fatih Kandemir, ve Aydın Genç. 2020. “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi 9 (2): 118-26. https://doi.org/10.46810/tdfd.809220.

EndNote

Gür C, Kandemir F, Genç A (01 Aralık 2020) Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. Türk Doğa ve Fen Dergisi 9 2 118–126.

IEEE

[1]C. Gür, F. Kandemir, ve A. Genç, “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”, TDFD, c. 9, sy 2, ss. 118–126, Ara. 2020, doi: 10.46810/tdfd.809220.

ISNAD

Gür, Cihan - Kandemir, Fatih - Genç, Aydın. “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi 9/2 (01 Aralık 2020): 118-126. https://doi.org/10.46810/tdfd.809220.

JAMA

1.Gür C, Kandemir F, Genç A. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. 2020;9:118–126.

MLA

Gür, Cihan, vd. “Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi”. Türk Doğa ve Fen Dergisi, c. 9, sy 2, Aralık 2020, ss. 118-26, doi:10.46810/tdfd.809220.

Vancouver

1.Cihan Gür, Fatih Kandemir, Aydın Genç. Bortezomib ile Kalp Hasarı Oluşturulan Ratlarda Berberinin Oksidatif ve Nitrozatif Stres Üzerine Etkisi. TDFD. 01 Aralık 2020;9(2):118-26. doi:10.46810/tdfd.809220