Evaluation Of Non-Metastatic Testicular Cancer Pathology Results: Our Clinical Experience And Review Of The Literature

Öz

Introduction:

Testicular cancer is a rarely seen malignancy in men with a ratio of 10/100000. Testicular cancers are mostly affecting adolescents, young adults and it comprises nearly %1 of

all male cancers.

Materials and Methods:

32 patients that were undergone radical orchidectomy due to testicular cancer between January 2007 and July 2016 were included in this study. The design of the study was retrospective.

Results:

When the pathologic materials were evaluated; 15 patients (46.8%) had mixt germ cell tumor, 9 patients (28.1%) had seminoma, 1 patient (3.1%) had testicular lymphoma, 3 patients (9.3%) had yolk sac tumor, 2 patients (6.2%) had hipocellular inflammatory myofibroblastic tumor(burned-out testicule tumor), 2 patients (6.2%) had sex cord stromal tumor.

Conclusion:

In our study we reviewed the histopathologic results of 32 patients. There were no lymph node or distant metastasis for the patients and during the follow-up program there were no recurrence or progression. Testicular cancers are important uropathologic entities for treatment and close follow up. Our clinical experience has been presented in the study.

Anahtar Kelimeler

• testicular,cancer,recurrence,metastasis

Nonmetastik Testis Tümörleri Patoloji Sonuçlarımız: Klinik Tecrübemiz Ve Literatür İncelemesi

Öz

Giriş:

Testis kanseri erkeklerde 10/100000 görülme oranı ile nadir görülen bir malignitedir. Testis kanseri çoğunlukla adolesanları, genç erişkinleri etkilemektedir ve tüm erkek kanserlerinin

yaklaşık %1’ini oluşturmaktadır.

Materyal ve Metod:

Ocak 2007 ve Temmuz 2016 tarihleri arasında 32 hastaya testis kanseri tanısıyla radikal orşiektomi operasyonu uygulandı ve çalışmaya dahil edildi. Çalışma retrospektif olarak dizayn edildi.

Bulgular:

Patolojik materyaller incelendiğinde; 15 hastada (%46.8) mikst germ hücreli tümör, 9 hastada (%28.1) seminom, 1 hastada (%3.1) testiküler lenfoma, 3 hastada (%9.3) yolk sak tümörü,

2 hastada (%6.2) hiposellüler inflamatuar miyofibroblastik tümör(burned-out testiküler tümör), 2 hastada (%6.2) seks kord stromal tümör saptandı.

Tartışma:

Çalışmamızda 32 hastanın histopatolojik sonuçları değerlendirildi. Hastalarda takiplerde lenf nodu metastazı veya uzak metastaz saptanmadı ve nüks ile progresyon gözlenmedi. Testis tümörleri tedavi ve yakın takibi önemli üropatolojik antitelerdir. Çalışmada klinik tecrübemiz sunulmuştur

Anahtar Kelimeler

• testis,kanseri,rekürrens,metastaz

Kaynakça

1. 1. Albers P, Albrecht W, Algaba F, et al. Guidelines on Testicular Cancer: 2015 Update. European urology. 2015;68:1054-68.
2. 2. Chakrabarti PR, Dosi S, Varma A, Kiyawat P, Khare G, Matreja S. Histopathological Trends of Testicular Neoplasm: An Experience over a Decade in a Tertiary Care Centre in the Malwa Belt of Central India. Journal of clinical and diagnostic research : JCDR. 2016;10:16-8.
3. 3. Ghazarian AA, Trabert B, Devesa SS, McGlynn KA. Recent trends in the incidence of testicular germ cell tumors in the United States. Andrology. 2015;3:13-8.
4. 4. Basiri A, Movahhed S, Parvin M, Salimi M, Rezaeetalab GH. The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior. Investigative and clinical urology. 2016;57:191-5.
5. 5. Kalin M, Mauti L, Pless M. [Testicular Cancer: Diagnostics, Therapy and Follow Up]. Praxis. 2016;105:643-8.
6. 6. Shtricker A, Silver D, Sorin E, et al. The value of testicular ultrasound in the prediction of the type and size of testicular tumors. International braz j urol : official journal of the Brazilian Society of Urology. 2015;41:655-60.
7. 7. Lim B, Song SH, Song G, Kim KS. Changes of calcific density in pediatric patients with testicular microlithiasis. Korean journal of urology. 2015;56:318-23.
8. 8. Cooper ML, Kaefer M, Fan R, Rink RC, Jennings SG, Karmazyn B. Testicular microlithiasis in children and associated testicular cancer. Radiology. 2014;270:857-63.

9. 9. Ryang SH, Jung JH, Eom M, et al. The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis. Korean journal of urology. 2015;56:515-8.
10. 10. Ayati M, Ariafar A, Jamshidian H, Soleimani A, Ghasemi F, Nowroozi MR. Management of nonpalpable incidental testicular masses: experience with 10 cases. Urology journal. 2014;11:1892-5.
11. 11. Ates F, Malkoc E, Zor M, et al. Testis-Sparing Surgery in Small Testicular Masses Not Suspected to Be Malignant. Clinical genitourinary cancer. 2016;14:49-53.
12. 12. Djaladat H. Organ-sparing surgery for testicular tumours. Current opinion in urology. 2015;25:116-20.
13. 13. Ondrusova M, Balogova S, Lehotska V, Kajo K, Mrinakova B, Ondrus D. Controversies in the management of clinical stage I testicular seminoma. Central European journal of urology. 2016;69:35-9.
14. 14. Ondrusova M, Ondrus D, Miskovska V, et al. Management of clinical stage I testicular seminoma: active surveillance versus adjuvant chemotherapy. International urology and nephrology. 2015;47:1143-7.
15. 15. Wei Y, Wu S, Lin T, et al. Testicular yolk sac tumors in children: a review of 61 patients over 19 years. World journal of surgical oncology. 2014;12:400.
16. 16. Downes MR, Cheung CC, Pintilie M, Chung P, van der Kwast TH. Assessment of intravascular granulomas in testicular seminomas and their association with tumour relapse and dissemination. Journal of clinical pathology. 2016;69:47-52.
17. 17. Zores T, Mouracade P, Duclos B, Saussine C, Lang H, Jacqmin D. [Surveillance of stage I testicular seminoma: 20 years oncological results]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2015;25:282-7.
18. 18. Toner GC. Testicular cancer: Optimal management of stage I seminoma in 2015. Nature reviews Urology. 2015;12:249-51.
19. 19. Tuzel E. Best treatment option for clinical stage I seminoma patients. Central European journal of urology. 2016;69:40-1.
20. 20. Dieckmann KP, Dralle-Filiz I, Matthies C, et al. Testicular seminoma clinical stage 1: treatment outcome on a routine care level. Journal of cancer research and clinical oncology. 2016;142:1599-607.
21. 21. Liu NW, Cary C, Strine AC, et al. Risk of Recurrence for Clinical Stage I and II Patients With Teratoma Only at Primary Retroperitoneal Lymph Node Dissection. Urology. 2015;86:981-4.
22. 22. Lauritsen J, Kier MG, Mortensen MS, et al. Germ Cell Cancer and Multiple Relapses: Toxicity and Survival. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015;33:3116-23.