Endometrial Polip ile Meme Hastalıkları Arasındaki İlişki

Abstract

GİRİŞ ve AMAÇ: Endometrial poliplerin etyolojisinde, endometrium kanseri ve meme kanserine benzer olarak östrojen maruziyeti bulunmaktadır. Çalışma; endometrial polibi olan hastaların meme hastalıkları açısından taranmasının, meme kanserinin erken tanısında katkısı olabileceğini incelemek amacıyla planlanmıştır. YÖNTEM ve GEREÇLER: Son 6 ayda jinekoloji polikliniğine başvurup endometrial örnekleme sonucu endometrial polip gelen toplam 348 hasta retrospektif olarak değerlendirilmiştir. Dosyasında meme ultasonografisi olan 151 olgu çalışmaya dahil edilmiştir. Menopozda olan 55 hasta, menapozda olmayan 96 hastanın demografik özellikleri ve meme ultrasonografi sonuçlarından oluşan veriler SPSS 23 programında analiz edilmiştir. BULGULAR: Herhangi bir meme kanseri olgusuna rastlanmamıştır. Menopozdaki endometrial polip hastalarında komplike kist, kanser şüphesi ve lenfadenopati oranı menapozda olmayanlara göre daha fazla saptanmıştır (p=0,000). Ailede meme kanseri öyküsünün olmasının endometrial poliple ilişkili olduğu tespit edilmiştir (p=0,002). Yaş (p=0,109), hormon kullanımı (p=0,806), meme yakınmasının (p=0,091), endometrial polip olup olmaması ile ilişkisi görülmemiştir TARTIŞMA ve SONUÇ: Endometrial polip ve memenin kanser şüphesi olan hastalıklarının etyolojilerindeki benzerlik nedeniyle birlikte bulunabilecekleri anlaşılmıştır. Meme hastalıkları ile endometriyal polip tespit edilen olguları prospektif olarak değerlendirecek bir çalışma ile bu durumun açıklık kazanabileceği kanaatine varılmıştır.

Keywords

• Endometrial Polip
• Meme Karsinomu
• Endometrial Küretaj

The Relationship Between Endometrial Polyp and Breast Pathologies

Abstract

INTRODUCTION: In the etiology of endometrial polyps, there is estrogen exposure similar to endometrial cancer and breast cancer. It was planned to examine the screening of patients with endometrial polyp for breast diseases, which may contribute to the early diagnosis of breast cancer. METHODS: In the last 6 months, a total of 348 patients who applied to the gynecology outpatient clinic and received endometrial polyp as a result of endometrial sampling were retrospectively evaluated. 151 cases with breast ultasonography in their file were included in the study. The demographic characteristics and breast ultrasonography results of 55 patients in menopause, 96 patients who were not in menopause were analyzed in SPSS 23 program. RESULTS: No breast cancer cases were encountered. Complicated cyst, suspicion of malignancy and lymphadenopathy rate were higher in patients with endometrial polyp in menopause than those without menopause (p = 0,000). It was determined that having a family history of breast cancer is associated with endometrial polyp (p = 0.002). The relationship between age (p = 0.109) hormone use (p = 0.806), breast complaint (p = 0.091) and endometrial polyp was not observed. DISCUSSION and CONCLUSION: It has been understood that the endometrial polyp and breast can be found together due to similarity in the etiology of cancer suspicious diseases. It was concluded that this situation could be clarified by a study that would prospectively evaluate cases with endometrial polyp with breast diseases.

Keywords

• Endometrial Polyp
• Breast Carcinoma
• Endometrial Curettage

References

1. American Cancer of Society (ACS). How many women get breast cancer in 2008? www.cancer.org /cancer reference information.
2. Slomovitz BM, Burke TW, Eifel P, Ramondetta LM, Silva EG, Jhingran A, et al. Uterine papillaryserous carcinoma (UPSC): a singleinstitution review of 129 cases. Gynecol Oncol 2003; 91:463–9.
3. Ronco AL, Stéfani E, Stoll M. Hormonal and metabolic modulation through nutrition: Towards a primary prevention of breast cancer: The Breast 2010;19 (5):322-332.
4. Mourouti N, Papavagelis C, Psaltopoulou T, Aravantinos G, Samantas E, Filopoulos E et al. Aims, design and methods of a case control study for the assessment of the role of dietary habits, eating behaviors and environmental factors, on the development of breast cancer. Maturitas 2013;74(1):31-6.
5. Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, Woodside JV. Dietary patterns and breast cancer risk: a systematic review and meta-analysis. American Journal of Clinical Nutrition 2010;91(5):1294-1302.
6. Peng X, Li T, Xia E, et al. A comparison of oestrogen receptor and progesterone receptor expression in endometrial polyps and endometrium of premenopausal women. J Obstet Gynaecol 2009; 29(4): 340–346.
7. Mittal K, Schwartz L, Goswami S, et al. Estrogen and progesterone receptor expression in endometrial polyps. Int J Gynecol Pathol 1996; 15(4): 345–348.
8. Sharman A: Menopause. In ZUCKERMAN S, Ed: O aıv. Vol l. New York NY Academic Press lnc pp: 1962,539-51.

9. Grattorola AR The premenstruel endometrial pattern of women with breast cancer. A study of progestationel activity. Cancer 1964,1119-22.
10. Smith SA, Saslow D, Sawyer D, Burke W, Constanza ME, Evans WP, et. al. American Cancer Society guidelines for breast cancer screening update 2003. CA Cancer J Clin 2003; 53:141-69.
11. Lubián López DM, Orihuela López F, García-Berbel Molina L, Boza Novo P, Pozuelo Solís E, et. al. Endometrial polyps in obese asymptomatic pre and postmenopausal patients with breast cancer: is screening necessary? Gynecol Oncol. 2014 Apr;133(1):56-62.
12. Brown SB1, Hankinson SE2. Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids. 2015 Jul;99 :8-10.
13. Lynch HT, Watson P, Conway TA, Lynch JF. Clinical/genetic features in hereditary breast cancer. Breast Cancer Res Treat 1990; 15: 63-71.
14. Murff HJ, Spigel DR, Syngal S. Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 2004; 292: 1480-1489.
15. Ellisen L, Haber D. Hereditary breast cancer. Ann Rev Med 1998: 49: 425-436.
16. Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 2001;358: 1389.
17. Liang SX, Pearl M, Liang S, Xiang L, Jia L, Yang B, et al. Personal history of breast cancer as a significant risk factor for endometrial serous carcinoma in women aged 55 years old or younger. Int J Cancer. 2011; 128:763-70.
18. Riboli E, Kaaks R. The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol. 1997;26(1):6–14.
19. Hankinson SE. Endogenous hormones and risk of breast cancer in postmenopausal women. Breast Dis. 2005; 24:3–15.