Tip 2 Diyabet Hastalarında Egzersizin Koroner Akım Rezervi ve Biyokimyasal Parametrelere Etkisi

Öz

Öz (tr) Diyabetik hastalarda en önemli mortalite ve morbidite nedenleri koroner, periferik ve serebrovasküler hastalıklarıdır. Çalışmamızın amacı, iskemi semtomları olmayan tip 2 diyabetli hastalarında transtorasik ekokardiyografi ile epikardiyal koroner arterlerdeki ve mikrovasküler dolaşımdaki disfonksiyonu noninvaziv olarak belirlemek ve 8 haftalık düzenli aerobic egzersizden sonra koroner akım rezervinde artış ile birlikte endotel fonksiyonlarında, glisemik kontrolde ve insülin direncinde iyileşmeyi göstermekti . Çalışmaya İstanbul Tıp Fakültesi Diyabet Anabilim Dalı'nda tip 2 diyabet tanısı almış, diyabet nedeniyle en az üç yıldır takipte olan, iskemik semptomu olmayan 40 hasta ve 20 sağlıklı birey katılmıştır. Egzersiz programına alınan diyabetik hastaların egzersiz öncesi bazal değerleri ile düzenli egzersiz yapmayan diyabetli hastaların bazal değerleri karşılaştırıldı. Fiziksel aktivite diyabetik hastalarda insülin duyarlılığını arttırır ve glukoz metabolizması üzerinde birçok olumlu etkiye sahiptir. Egzersiz obezite ve viseral yağ dokusunu azaltmanın en önemli yoludur. Düzenli egzersizin diyabetin başlamasını erteleyebileceğine ve hatta önleyebileceğine işaret eden kanıtlar vardır.

Anahtar Kelimeler

• egzersiz
• koroner akım rezervi
• tip iki diyabetes mellitus

Effects of Exercise On Coronary Flow Reserve And Biochemical Parameters in Patients With Type 2 Diabetes Mellitus

Abstract

The most important mortality and morbidity causes in diabetic patients are coronary, peripheral and cerebral diseases. The aim of our study was to noninvasively determine dysfunction in epicardial coronary arteries and microvascular circulation with measurement of coronary flow reserve using transthoracic echocardiography in patients with type 2 diabetes despite absence of ischemic symptoms, and to demonstrate the amelioration in endothelial functions, glycemic control and insulin resistance along with increase in coronary flow reserve after 8 weeks of regular exercise. 40 patients diagnosed with type 2 diabetes in Istanbul Facuty of Medicine, Department of Diabetes, who were on follow-up for at least three years due to diabetes, without ischemic symptoms and 20 healthy subjects took part in study. Basal values before exercise of diabetic patients who were included in the exercise program were compared with basal values of diabetic patients who did not exercise regularly. To summarize, regular exercise and physical activity are highly important in diabetic patients for primary and secondary protection against cardiovascular incidents. Physical activity increases insulin sensitivity in diabetic patients, and has many positive effects on glucose metabolism. It is the important way to decrease obesity and visceral fat tissue. There is evidence pointing out that regular exercise can defer or even prevent initiation of diabetes.

Keywords

• exercise
• coronary flow rezerve
• type 2 diabetes mellitus

Kaynakça

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