Is metabolic syndrome related to postmenopausal osteoporosis? A retrospective study

Yıl 2018, , 71 - 74, 20.07.2018

Elif Turan , Hafize Kızılkaya Yalçın Aral

https://doi.org/10.25000/acem.419847

Öz

Aim: To evaluate the difference between postmenopausal women with and without
osteoporosis in terms of metabolic syndrome.

Methods: A total of 98 postmenopausal women younger than 65 years, were enrolled
in the study. According to the
bone mineral density examination; 49 participants who had T-score>−2.5 at
the spine or/and femoral neck were included in the group without osteoporosis
(Group 1), and 49 participants who had T-score≤−2.5 at the spine or/and femoral
neck were included in the osteoporosis group (Group 2). Patient’s profile which
included all demographic data, particularly anthropometric evaluation
and medical history was
obtained. Serum fasting glucose, lipid profiles and 25 OH vitamin D levels were
also recorded.

Results: Age (p=0.001), menopausal age (p=0.003), systolic
blood pressure (p=0.004) and diastolic blood pressure (p=0.001) of Group 2 were
significantly higher than Group 1. There were no significant difference in
terms of body mass index, weight, lipid profiles, serum calcium and serum 25 OH
vitamin D levels among the groups (p>0.05 for all). Twenty five (51%) of 49
women in Group 1 and 36 (73%) of 49 women in Group 2 had metabolic syndrome.
There was a statistically significant relationship between osteoporosis and the
metabolic syndrome (p=0.037).

Conclusion: Our results demonstrated that osteoporosis is related with the
metabolic syndrome in postmenopausal women.

Anahtar Kelimeler

metabolic syndrome, osteoporosis, menopause

Metabolik sendrom postmenopozal osteoporoz ile ilişkili midir? Retrospektif bir çalışma

Öz

Amaç: Postmenopozal kadınlarda, osteoporoz ile metabolik sendrom
arasındaki ilişkiyi değerlendirmek.

Yöntemler: 65 yaşın altında toplam 98
postmenopozal kadın çalışmaya dahil edildi. Kemik mineral dansitometre sonucuna
göre; lumber ve/veya femur boyun T skoru>-2.5 olan 49 hasta postmenopozal
osteoporoz olmayan gruba (Grup 1), T skoru≤-2.5 olan 49 hasta postmenopozal osteoporoz
grubuna (Grup 2) dahil edildi. Tüm demografik verileri içeren hasta profili,
antropometrik değerlendirme ve tıbbi öykü kaydedildi. Serum açlık glukozu,
lipit profili ve serum 25 OH D vitamin seviyesi de kaydedildi.

Bulgular: Grup 1 ve Grup 2 karşılaştırıldığında;
yaş (p=0.001), menopoz yaşı (p=0.003) sistolik kan basıncı (p=0.004) ve diyastolik
kan basıncı (p=0.001) Grup 2’de Grup 1’e göre anlamlı şekilde daha yüksekti. Vücut
kitle indeksi, boy, kilo, lipid profili, serum 25 OH vitamin D düzeyleri açısından
gruplar arasında anlamlı fark yoktu (p>0.05). Osteoporozu olan 49 hastanın
36’sında (%73), osteoporozu olmayan 49 hastanın ise 25’inde (%51) metabolik sendrom
tespit edildi. Osteoporoz ile metabolik sendrom arasında istatistiksel olarak anlamlı
ilişki tespit edildi (p=0,037).

Sonuç: Postmenopozal kadınlarda osteoporoz ile metabolik
sendrom arasında anlamlı ilişki olduğu tespit edilmiştir.

Anahtar Kelimeler

Metabolik sendrom, menopoz, osteoporoz

Kaynakça

• 1. Isomaa B. A major health hazard: the metabolic syndrome. Life Sci. 2003;73:2395-411.
• 2. Lorenzo C, Williams K, Hunt KJ, Haffner SM. The National Cholesterol Education Program–Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care. 2007;30:8-13.
• 3. Gundogan K, Bayram F, Gedik V, Kaya A, Karaman A, Demir O, et al. Metabolic syndrome prevalence according to ATP III and IDF criteria and related factors in Turkish adults. Arch Med Sci. 2013;9:243.
• 4. Melton III LJ, Chrischilles EA, Cooper C, Lane AW, Riggs BL. Perspective how many women have osteoporosis? J Bone Miner Res. 1992;7:1005-10.
• 5. Sprini D, Rini GB, Di Stefano L, Cianferotti L, Napoli N. Correlation between osteoporosis and cardiovascular disease. Clin Cases Miner Bone Met. 2014;11:117.
• 6. Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004;24:e6-e10.
• 7. Jankowska E, Rogucka E, Mędraś M. Are general obesity and visceral adiposity in men linked to reduced bone mineral content resulting from normal ageing? A population-based study. Andrologia. 2001;33:384-9.
• 8. Blaauw R, Albertse EC, Hough S. Body fat distribution as a risk factor for osteoporosis. South Afr Med J. 1996;86(9).
• 9. Silva HG, Mendonça L, Conceição FL, Zahar SE, Farias MLF. Influence of obesity on bone density in postmenopausal women. Arq Bras Endocrinol Metabol. 2007;51:943-9.
• 10. Lindsay R, Cosman F, Herrington BS, Himmelstein S. Bone mass and body composition in normal women. J Bone Miner Res. 1992;7:55-63.
• 11. Anagnostis P, Karagiannis A, Kakafika AI, Tziomalos K, Athyros VG, Mikhailidis DP. Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities? Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. Osteopoprs Int. 2009;20:197-207.
• 12. McFarlane SI, Muniyappa R, Shin JJ, Bahtiyar G, Sowers JR. Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link? Endocrine. 2004;23:1-10.
• 13. Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, et al. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26:1554-60.
• 14. Cummings S. Factors associated with appendicular bone mass in older women. Ann Intern Med. 1993;118:657-65.
• 15. Grady D, Rubin SM, Petitti DB, Fox CS, Black D, Ettinger B, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Int Med. 1992;117:1016-37.
• 16. Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, Chomka EV. Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int. 1998;62:209-13.
• 17. Banks L, Lees B, MacSweeney J, Stevenson J. Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: links between osteoporosis and cardiovascular disease? Eur J Clin Invest. 1994;24:813-7.
• 18. Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014;105:141-50.
• 19. Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation–mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012;32:1771-6.
• 20. Ginaldi L, Di Benedetto MC, De Martinis M. Osteoporosis, inflammation and ageing. Immun Ageing. 2005;2:14.
• 21. Kaya A, Turan E, Uyar M, Bayram F, Turan Y. The Prevalence of Insulin Resistance in the Turkish Population: A Study Conducted with 3331 Participants. EJMO. 2017;1:202-6. DOI: 10.14744/ejmo.2017.02886
• 22. Hernández J, Olmos J, González-Macías J. Metabolic syndrome, fractures and gender. Maturitas. 2011;68:217-23.
• 23. Esposito K, Chiodini P, Capuano A, Colao A, Giugliano D. Fracture risk and bone mineral density in metabolic syndrome: a meta-analysis. J Clin Endocrinol Metab. 2013;98:3306-14.
• 24. Von Muhlen D, Safii S, Jassal S, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007;18:1337-44.