Araştırma Makalesi
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Cervical blood flow velocity values in patients with unilateral intracranial aneurysm: Preliminary results

Yıl 2019, , 49 - 53, 15.03.2019
https://doi.org/10.25000/acem.451820

Öz

Aim: Brain aneurysm is a balloon
shaped dilatation of brain vessels as a result of attenuation of the vessel
walls. The aim of this study was to evaluate the relationship between blood
flow velocities in the right and left arterial vessels in an unruptured
aneurysm and healthy group, and to investigate whether this analysis can help
early diagnosis of aneurysm.

Methods: Four aneurysm
patients (four female, mean age 57.25 ± 0.75 years) and four healthy subjects (two
female, 2 male male, mean age 36.35 ± 6.19 years) were included in the study.
Blood flow velocity values ​​of right and left internal carotid arteries,
vertebral artery and right and left internal jugular veins were obtained during
a cardiac cycle with phase contrast technique. Spearman's correlation analysis
was applied to flow velocity values. Statistically significant blood flow
similarities between right and left brain were investigated.

Results: In the aneurysm group, there
was a significant difference between right and left cervical arterial blood
flow velocity values (p=0.001). Spearman correlation coefficient values between
right and left arterial blood flow velocity values and right and left side
arteriovenous blood flow velocity values were lower in the aneurysm group
compared to the control group however, there was no statistical significance
(p≥0.05 for all).







Conclusion:  The difference between the right and left
arterial blood flow velocities obtained in the aneurysm group and the low
correlation values may be useful in early diagnosis of aneurysm. 

Kaynakça

  • 1. Doddasomayajula R, Chung B, Hamzei-Sichani F, Putman CM, Cebral JR. Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries. AJNR Am J Neuroradiol. 2017;38:570-6.
  • 2. Zhao L, Zhang L, Zhang X, Li Z, Tian L, Wang Y-XJ. An Analysis of 1256 Cases of Sporadic Ruptured Cerebral Aneurysm in a Single Chinese Institution. PLoS One. 2014;19:e85668.
  • 3. Wang R, Zhang D, Zhao J, Wang S, Zhao Y, Niu H. A comparative study of 43 patients with mirror-like intracranial aneurysms: risk factors, treatment, and prognosis. Neuropsychiatr Dis Treat. 2014;10:2231-7.
  • 4. Hu P, Qian Y, Lee CJ, Zhang HQ, Ling F. The energy loss may predict rupture risks of anterior communicating aneurysms: a preliminary result. Int J Clin Exp Med. 2015;8:4128-33.
  • 5. Berg P, Beuing O. Multiple intracranial aneurysms: a direct hemodynamic comparison between ruptured and unruptured vessel malformations. Int J Comput Assist Radiol Surg. 2018;13:83-93.
  • 6. Liu J, Fan J, Xiang J, Zhang Y, Yang X. Hemodynamic characteristics of large unruptured internal carotid artery aneurysms prior to rupture: a case control study. J Neurointerv Surg. 2016;8:367-72.
  • 7. Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK et al. MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries. J Cereb Blood Flow Metab. 2009;29:1975-82.
  • 8. El Sankari S G-JC, Fichten A, Godefroy O, Serot JM, Deramond H, Meyer ME, et al. Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2011;8:12.
  • 9. Boussel L, Rayz V, Martin A, Acevedo-Bolton G, Lawton MT, Higashida R et al. Phase-Contrast Magnetic Resonance Imaging Measurements in Intracranial Aneurysms In Vivo of Flow Patterns, Velocity Fields, and Wall Shear Stress: Comparison with Computational Fluid Dynamics. Magn Reson Med. 2009;61:409-17.
  • 10. Karmonik C, Yen C, Grossman RG, Klucznik R, Benndorf G. Intra-aneurysmal flow patterns and wall shear stresses calculated with computational flow dynamics in an anterior communicating artery aneurysm depend on knowledge of patient-specific inflow rates. Acta Neurochir (Wien). 2009;151:479-85.
  • 11. Hussein AE, Brunozzi D, Shakur SF, Ismail R, Charbel FT, Alaraj A. Cerebral Aneurysm Size and Distal Intracranial Hemodynamics: An Assessment of Flow and Pulsatility Index Using Quantitative Magnetic Resonance Angiography. Neurosurgery. 2018;83:660-5.
  • 12. Alperin N, Vikingstad EM, GomezAnson B, Levin DN. Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI. Magn Reson Med. 1996;35:741-54.
  • 13. Filatova OV, Sidorenko AA, Skorobogatov YY. Age and Sex Dependence of Hemodynamic Parameters of Human Internal Carotid Arteries. Hum Physiol. 2014;40:554-62.
  • 14. Salk İ, Yıldız G, Eğilmez H, Atalar MH, Candan F, Çetin A. Carotid artery Doppler ultrasonography in patients with chronic kidney disease. Med Sci Monit. 2014;20:11-7.
  • 15. Al-Eqabi DAM, Al-Sıaıdy WF, Al-Sabbagh AAJ, Al-Kırwi IN. Internal Carotid Peak-Systolic and End-Diastolic Velocities are the Sensitive Parameters in Predicting Conditions in Type 2 Diabetes. J Biomed Bioeng. 2013;4:90-2.
  • 16. Hope TA, Hope MD, Purell DD, von Morze C, Vigneron DB, Alley MT et al. Evaluation of intracranial stenoses and aneurysms with accelerated 4D flow. Magn Reson Imaging. 2010;28:41-6.

Tek taraflı intrakranial anevrizmalı hastalarda servikal kan akış hızı değerleri: Ön sonuçlar

Yıl 2019, , 49 - 53, 15.03.2019
https://doi.org/10.25000/acem.451820

Öz

Amaç: Beyin anevrizması damar
çeperlerindeki zayıflama sonucu beyin damarlarında oluşan balon şeklinde
genişlemedir. Bu araştırmanın amacı, kanamasız anevrizmalı ve sağlıklı grupta
sağ ve sol arteriyel damarlardaki kan akış hızlarını değerlendirmek ve bu
analizin anevrizma ön tanısına yardımcı olup olamayacağını araştırmaktır.

Yöntemler: Araştırmaya dört anevrizma
hastası (dört kadın, ortalama yaş 57,25 ± 0,75) ve dört sağlıklı denek  (iki kadın, iki erkek, ortalama yaş 36,35 ±
6,19) dahil edildi. Sağ ve sol iç karotis arter, vertebral arter ve sağ ve sol
iç jugular ven kan akış hızı değerleri faz kontrast tekniği ile bir kardiyak
döngü boyunca elde edildi. Spearman’ın ilişki analizi akış hızı değerlerine
uygulandı. Beyinin sağı ve solu arasındaki istatistiksel olarak anlamlı kan akış
benzerlikleri araştırıldı.

Bulgular: Anevrizma grubunda,  sağ ve sol taraf servikal arteriyel kan akış
hızı değerleri arasında anlamlı fark bulundu (p=0,001). Sağ ve sol arteriyel
kan akış hızı değerleri arasındaki ve sağ ve sol taraf arteriyovenöz kan akış
hızı değerleri arasındaki Spearman ilişki katsayı değerleri anevrizma grubunda
kontrol grubuna göre düşüktü, ancak istatistiksel anlamlılık yoktu (hepsi  için p≥0,05).







Sonuç: Bu ön araştırmanın sonuçları, anevrizma
grubunda elde edilen sağ ve sol arteriyel kan akış hızları arasındaki belirgin
farkın ve düşük ilişki değerlerinin anevrizma tanısında faydalı olabileceğini
düşündürdü. 

Kaynakça

  • 1. Doddasomayajula R, Chung B, Hamzei-Sichani F, Putman CM, Cebral JR. Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries. AJNR Am J Neuroradiol. 2017;38:570-6.
  • 2. Zhao L, Zhang L, Zhang X, Li Z, Tian L, Wang Y-XJ. An Analysis of 1256 Cases of Sporadic Ruptured Cerebral Aneurysm in a Single Chinese Institution. PLoS One. 2014;19:e85668.
  • 3. Wang R, Zhang D, Zhao J, Wang S, Zhao Y, Niu H. A comparative study of 43 patients with mirror-like intracranial aneurysms: risk factors, treatment, and prognosis. Neuropsychiatr Dis Treat. 2014;10:2231-7.
  • 4. Hu P, Qian Y, Lee CJ, Zhang HQ, Ling F. The energy loss may predict rupture risks of anterior communicating aneurysms: a preliminary result. Int J Clin Exp Med. 2015;8:4128-33.
  • 5. Berg P, Beuing O. Multiple intracranial aneurysms: a direct hemodynamic comparison between ruptured and unruptured vessel malformations. Int J Comput Assist Radiol Surg. 2018;13:83-93.
  • 6. Liu J, Fan J, Xiang J, Zhang Y, Yang X. Hemodynamic characteristics of large unruptured internal carotid artery aneurysms prior to rupture: a case control study. J Neurointerv Surg. 2016;8:367-72.
  • 7. Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK et al. MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries. J Cereb Blood Flow Metab. 2009;29:1975-82.
  • 8. El Sankari S G-JC, Fichten A, Godefroy O, Serot JM, Deramond H, Meyer ME, et al. Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2011;8:12.
  • 9. Boussel L, Rayz V, Martin A, Acevedo-Bolton G, Lawton MT, Higashida R et al. Phase-Contrast Magnetic Resonance Imaging Measurements in Intracranial Aneurysms In Vivo of Flow Patterns, Velocity Fields, and Wall Shear Stress: Comparison with Computational Fluid Dynamics. Magn Reson Med. 2009;61:409-17.
  • 10. Karmonik C, Yen C, Grossman RG, Klucznik R, Benndorf G. Intra-aneurysmal flow patterns and wall shear stresses calculated with computational flow dynamics in an anterior communicating artery aneurysm depend on knowledge of patient-specific inflow rates. Acta Neurochir (Wien). 2009;151:479-85.
  • 11. Hussein AE, Brunozzi D, Shakur SF, Ismail R, Charbel FT, Alaraj A. Cerebral Aneurysm Size and Distal Intracranial Hemodynamics: An Assessment of Flow and Pulsatility Index Using Quantitative Magnetic Resonance Angiography. Neurosurgery. 2018;83:660-5.
  • 12. Alperin N, Vikingstad EM, GomezAnson B, Levin DN. Hemodynamically independent analysis of cerebrospinal fluid and brain motion observed with dynamic phase contrast MRI. Magn Reson Med. 1996;35:741-54.
  • 13. Filatova OV, Sidorenko AA, Skorobogatov YY. Age and Sex Dependence of Hemodynamic Parameters of Human Internal Carotid Arteries. Hum Physiol. 2014;40:554-62.
  • 14. Salk İ, Yıldız G, Eğilmez H, Atalar MH, Candan F, Çetin A. Carotid artery Doppler ultrasonography in patients with chronic kidney disease. Med Sci Monit. 2014;20:11-7.
  • 15. Al-Eqabi DAM, Al-Sıaıdy WF, Al-Sabbagh AAJ, Al-Kırwi IN. Internal Carotid Peak-Systolic and End-Diastolic Velocities are the Sensitive Parameters in Predicting Conditions in Type 2 Diabetes. J Biomed Bioeng. 2013;4:90-2.
  • 16. Hope TA, Hope MD, Purell DD, von Morze C, Vigneron DB, Alley MT et al. Evaluation of intracranial stenoses and aneurysms with accelerated 4D flow. Magn Reson Imaging. 2010;28:41-6.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orjinal Makale
Yazarlar

Engin Tekin 0000-0002-7073-3301

Murat Pehlivan 0000-0003-1582-1517

Ömer Kitiş Bu kişi benim 0000-0003-4201-5449

Yayımlanma Tarihi 15 Mart 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

Vancouver Tekin E, Pehlivan M, Kitiş Ö. Cervical blood flow velocity values in patients with unilateral intracranial aneurysm: Preliminary results. Arch Clin Exp Med. 2019;4(1):49-53.