Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF

Hasan Can Könte; Ömer Alyan; Dursun Aras

doi:10.38053/acmj.1852985

Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF

Abstract

Aims: To evaluate the predictive value of the Naples prognostic score (NPS) and other nutritional indices for appropriate implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients with heart failure with reduced ejection fraction (HFrEF). Methods: This retrospective cohort study included 288 adult patients with HFrEF who underwent primary prevention ICD implantation and followed for at least six months. Data were retrospectively collected from electronic medical records. The NPS, PNI, and CONUT scores were calculated from baseline laboratory values obtained at the time of ICD implantation. The primary endpoint was the predictive performance of NPS for appropriate ICD therapy. Results: Patients with appropriate therapy (n=194) were younger (p=0.002), had lower BMI (p<0.001), hemoglobin (p=0.020), and ischemic cardiomyopathy prevalence (p=0.025). Left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (p=0.002) were higher in recipients of appropriate ICD shocks. Nutritional scores showed better nutritional status in the appropriate therapy group: higher PNI (p<0.001), lower NPS (p=0.001) and lower CONUT (p=0.015). ROC analysis revealed similar and modest discriminatory capabilities for all nutrition assessment tools (AUCs from 0.587 to 0.630). Multivariable logistic regression identified low BMI (p=0.002), high LVEDD (p=0.007), and high albumin (p<0.001) as independent predictors of appropriate therapy. Conclusion: In primary prevention ICD recipients with HFrEF, appropriate therapy was linked to lower BMI, higher LVEDD, and elevated albumin, while nutritional indices showed univariate but not multivariable predictive value. The relatively high negative predictive values suggest a screening/supportive role for NPS (and other nutritional scores) in the context of ICD management in patients with HFrEF.

Keywords

References

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Details

Primary Language

English

Subjects

Cardiology, Predictive and Prognostic Markers, Medical Biochemistry and Metabolomics (Other), Medical Devices, Health and Ecological Risk Assessment

Journal Section

Research Article

Authors

Hasan Can Könte ^*
0000-0001-9321-5673
Türkiye

Ömer Alyan
0000-0002-4354-0918
Türkiye

Dursun Aras
0000-0002-3871-9219
Türkiye

Publication Date

March 10, 2026

Submission Date

December 31, 2025

Acceptance Date

February 7, 2026

Published in Issue

Year 2026 Volume: 8 Number: 2

DOI

https://doi.org/10.38053/acmj.1852985

IZ

https://izlik.org/JA27ET54XM

Cite

RIS / Bibtex

APA

Könte, H. C., Alyan, Ö., & Aras, D. (2026). Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF. Anatolian Current Medical Journal, 8(2), 270-276. https://doi.org/10.38053/acmj.1852985

AMA

1.Könte HC, Alyan Ö, Aras D. Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF. Anatolian Curr Med J / ACMJ / acmj. 2026;8(2):270-276. doi:10.38053/acmj.1852985

Chicago

Könte, Hasan Can, Ömer Alyan, and Dursun Aras. 2026. “Naples Prognostic Score, Prognostic Nutritional Index, and CONUT Score in Predicting Implantable Cardioverter-Defibrillator Therapy Outcomes in HFrEF”. Anatolian Current Medical Journal 8 (2): 270-76. https://doi.org/10.38053/acmj.1852985.

EndNote

Könte HC, Alyan Ö, Aras D (March 1, 2026) Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF. Anatolian Current Medical Journal 8 2 270–276.

IEEE

[1]H. C. Könte, Ö. Alyan, and D. Aras, “Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 2, pp. 270–276, Mar. 2026, doi: 10.38053/acmj.1852985.

ISNAD

Könte, Hasan Can - Alyan, Ömer - Aras, Dursun. “Naples Prognostic Score, Prognostic Nutritional Index, and CONUT Score in Predicting Implantable Cardioverter-Defibrillator Therapy Outcomes in HFrEF”. Anatolian Current Medical Journal 8/2 (March 1, 2026): 270-276. https://doi.org/10.38053/acmj.1852985.

JAMA

1.Könte HC, Alyan Ö, Aras D. Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF. Anatolian Curr Med J / ACMJ / acmj. 2026;8:270–276.

MLA

Könte, Hasan Can, et al. “Naples Prognostic Score, Prognostic Nutritional Index, and CONUT Score in Predicting Implantable Cardioverter-Defibrillator Therapy Outcomes in HFrEF”. Anatolian Current Medical Journal, vol. 8, no. 2, Mar. 2026, pp. 270-6, doi:10.38053/acmj.1852985.

Vancouver

1.Hasan Can Könte, Ömer Alyan, Dursun Aras. Naples prognostic score, Prognostic Nutritional Index, and CONUT score in predicting implantable cardioverter-defibrillator therapy outcomes in HFrEF. Anatolian Curr Med J / ACMJ / acmj. 2026 Mar. 1;8(2):270-6. doi:10.38053/acmj.1852985