Research Article
BibTex RIS Cite

Comparison of iron, vitamin B12, and vitamin D levels in healthy children and children with speech and language disorders

Year 2025, Volume: 7 Issue: 2, 218 - 222, 21.03.2025
https://doi.org/10.38053/acmj.1583966

Abstract

Aims: This study investigated the relationship between speech and language disorders in children and their levels of vitamin D (25(OH)D3), vitamin B12, and iron.
Methods: A total of 163 children participated in the study. Among 111 children diagnosed with speech and language disorders, the distribution included stuttering (n=12), articulation disorder (n=55), developmental language disorder (n=36), fluency disorder (n=4), atypical autism (n=3), and rapid speech disorder (n=1). Additionally, 52 healthy children were included as a control group. The levels of iron, vitamin B12, and vitamin D were recorded for both groups.
Results: Average levels in the study group were as follows: vitamin D at 24.88±14.788 ng/ml, vitamin B12 at 267.43±174.523 pg/ ml, and iron at 74.19±34.479 µg/dl. Iron levels were significantly lower in children with speech disorders compared to those in the control group (z=1.986, p=0.049). However, no significant differences were found among the various subgroups of speech disorders in terms of iron, vitamin B12, or vitamin D levels. A positive correlation was observed between vitamin D and vitamin B12 levels within the speech disorder group (p<0.05).
Conclusion: This study suggests a potential link between lower iron levels and speech disorders, though further research is required to validate these findings in children with speech and language disorders.

Supporting Institution

NO

Thanks

I would like to thank our hospital's speech and language therapist F.B.K. for his contributions.

References

  • Silverman FH. Stuttering and other fluency disorders. Illinois: Waveland Press. 2004
  • Maria-Mengel MR, Martins Linhares MB. Risk factors for infant developmental problems. Rev Lat Am Enfermagem. 2007;15 Spec No: 837-842. doi:10.1590/s0104-11692007000700019
  • Samra HA, McGrath JM, Wehbe M. An integrated review of developmental outcomes and late-preterm birth. J Obstet Gynecol Neonatal Nurs. 2011;40(4):399-411. doi:10.1111/j.1552-6909.2011.01270.x
  • Hall NE. Developmental language disorders. Semin Pediatr Neurol. 1997;4(2):77-85. doi:10.1016/s1071-9091(97)80023-x
  • Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008;29(2 Suppl):S126-131. doi:10.1177/15648265080292S117
  • Lövblad K, Ramelli G, Remonda L, Nirkko AC, Ozdoba C, Schroth G. Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol. 1997;27(2):155-158. doi:10.1007/s002470050090
  • Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr. 2007;85(2):614S-620S. doi:10.1093/ajcn/85.2.614S
  • Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008; 29(6):726-776. doi:10.1210/er.2008-0004
  • Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am. 2010;39(2):381-400. doi:10.1016/j.ecl.2010.02.016
  • Gilchrest BA. Sun exposure and vitamin D sufficiency. Am J Clin Nutr. 2008;88(2):570S-577S. doi:10.1093/ajcn/88.2.570S
  • Topbaş S. Turkish pronunciation-photophony test: validity-reliability and standardization study Turkish journal of psychology. Türk Psikoloji Derg. 2006;21(58):39-56.
  • Topbaş S, Güven OS. Turkish Early Language Development Test- TEDİL, Test Battery. Ankara: Detay Publishing, 2011.
  • Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-281. doi:10.1056/NEJMra070553
  • Sezgin Evim M, Erdöl Ş, Özdemir Ö, Baytan B, Güneş AM. Long-term outcome in children with nutritional vitamin B12 deficiency. Turk J Haematol. 2011;28(4):286-293. doi:10.5152/tjh.2011.82
  • Rose SA, Feldman JF, Jankowski JJ. A cognitive approach to the development of early language. Child Dev. 2009;80(1):134-150. doi:10. 1111/j.1467-8624.2008.01250.x
  • Cui X, Eyles DW. Vitamin D and the central nervous system: causative and preventative mechanisms in brain disorders. Nutrients. 2022;14(20): 4353. doi:10.3390/nu14204353
  • Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab. 2002;13(3):100-105. doi:10.1016/s1043-2760(01)00547-1
  • Brown J, Bianco JI, McGrath JJ, Eyles DW. 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett. 2003; 343(2):139-143. doi:10.1016/s0304-3940(03)00303-3
  • Annweiler C, Allali G, Allain P, et al. Vitamin D and cognitive performance in adults: a systematic review. Eur J Neurol. 2009;16(10): 1083-1089. doi:10.1111/j.1468-1331.2009.02755.x
  • Sağıroğlu S. A comparison of vitamin D levels in chidren with language and speech disorders and healthy children in the Turkish population. Türkiye Çocuk Hast Derg. 2020;14(2):158-163. doi:10.12956/tchd.562170
  • Golding J, Gregory S, Clark R, et al. Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood. Nutr Res. 2021;86:68-78. doi:10.1016/j.nutres.2020.12.005
  • Villamor E, Rifas-Shiman SL, Gillman MW, Oken E. Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. Paediatr Perinat Epidemiol. 2012;26(4):328-335. doi:10.1111/j.1365-3016.2012.0 1264.x
  • Boeke CE, Gillman MW, Hughes MD, Rifas-Shiman SL, Villamor E, Oken E. Choline intake during pregnancy and child cognition at age 7 years. Am J Epidemiol. 2013;177(12):1338-1347. doi:10.1093/aje/kws395
  • Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev. 2008; 66(5):250-255. doi:10.1111/j.1753-4887.2008.00031.x
  • Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006;13(3):158-165. doi:10.1016/j.spen.2006.08.004
  • Beltrán-Navarro B, Matute E, Vásquez-Garibay E, Zarabozo D. Effect of chronic iron deficiency on neuropsychological domains in infants. J Child Neurol. 2012;27(3):297-303. doi:10.1177/0883073811416867
  • Yasin A, Aksu H, Ozgür E, Ozgür BG. Speech and language delay in childhood: a retrospective chart review. ENT Updates. 2017;7(1):22-27. doi:10.2399/jmu.2017001004
There are 27 citations in total.

Details

Primary Language English
Subjects Infant and Child Health
Journal Section Research Articles
Authors

Ramazan Dulkadir 0000-0002-6640-9277

Publication Date March 21, 2025
Submission Date January 31, 2025
Acceptance Date March 11, 2025
Published in Issue Year 2025 Volume: 7 Issue: 2

Cite

AMA Dulkadir R. Comparison of iron, vitamin B12, and vitamin D levels in healthy children and children with speech and language disorders. Anatolian Curr Med J / ACMJ / acmj. March 2025;7(2):218-222. doi:10.38053/acmj.1583966

TR DİZİN ULAKBİM and International Indexes (1b)

Interuniversity Board (UAK) Equivalency:  Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]

Note: Our journal is not WOS indexed and therefore is not classified as Q.

You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/3449/file/4924/show

Journal Indexes and Platforms: 

TR Dizin ULAKBİM, Google Scholar, Crossref, Worldcat (OCLC), DRJI, EuroPub, OpenAIRE, Turkiye Citation Index, Turk Medline, ROAD, ICI World of Journal's, Index Copernicus, ASOS Index, General Impact Factor, Scilit.


The indexes of the journal's are;

18596


asos-index.png

f9ab67f.png

WorldCat_Logo_H_Color.png

      logo-large-explore.png

images?q=tbn:ANd9GcQgDnBwx0yUPRKuetgIurtELxYERFv20CPAUcPe4jYrrJiwXzac8rGXlzd57gl8iikb1Tk&usqp=CAU

index_copernicus.jpg


84039476_619085835534619_7808805634291269632_n.jpg





The platforms of the journal's are;

COPE.jpg

images?q=tbn:ANd9GcTbq2FM8NTdXECzlOUCeKQ1dvrISFL-LhxhC7zy1ZQeJk-GGKSx2XkWQvrsHxcfhtfHWxM&usqp=CAUicmje_1_orig.png

cc.logo.large.png

ncbi.png

ORCID_logo.pngimages?q=tbn:ANd9GcQlwX77nfpy3Bu9mpMBZa0miWT2sRt2zjAPJKg2V69ODTrjZM1nT1BbhWzTVPsTNKJMZzQ&usqp=CAU


images?q=tbn:ANd9GcTaWSousoprPWGwE-qxwxGH2y0ByZ_zdLMN-Oq93MsZpBVFOTfxi9uXV7tdr39qvyE-U0I&usqp=CAU






The
 
indexes/platforms of the journal are;

TR Dizin Ulakbim, Crossref (DOI), Google Scholar, EuroPub, Directory of Research Journal İndexing (DRJI), Worldcat (OCLC), OpenAIRE, ASOS Index, ROAD, Turkiye Citation Index, ICI World of Journal's, Index Copernicus, Turk Medline, General Impact Factor, Scilit 


EBSCO, DOAJ, OAJI is under evaluation.

Journal articles are evaluated as "Double-Blind Peer Review"