High versus low dialysate sodium: a single-center small-scale prospective study

Year 2025, Volume: 7 Issue: 2, 196 - 200, 21.03.2025

Sara İleri

https://doi.org/10.38053/acmj.1626469

Abstract

Aims: The matter of dialysate sodium concentration has become progressively substantial in the last 50 years, when dialysis modalities have advanced quickly. In many studies, it has been established that dialysate sodium value is correlated with blood pressure alternance, hypervolemia, interdialytic weight gain (IDWG), and chronic inflammation. However, there is no clear knowledge about its direct effect on inflammation. In this study, we profited from high-sensitivity C-reactive protein (hs-CRP), which is a helpful marker, to survey the inflammation correlation with dialysate sodium (DNa).
Methods: 109 non-diabetic hemodialysis patients were enrolled in the study. All patients participating in the study were new onset, less than 6 months dialysis patients and met Kt/V of 1.4 at minimum criteria.
Results: They were divided into two groups: group 1, low dialysate sodium (137 mmol/L) and group 2, conventional dialysate sodium (140 mmol/L) and followed-up for two months. During the follow-up period, serum hs-CRP levels were measured and categorized as baseline, 1st month and second month level.
Conclusion: As a result, no statistically remarkable disparity between the groups were determined in terms of serum hs-CRP levels at baseline, 1st month, and 2nd month of the study (p>0.05). We did not establish any significant differences that would make it worth ignoring some symptoms symptoms such as cramps and hypotension.

Keywords

Chronic kidney disease, hemodialysis, dialysate sodium, chronic inflammation, high-sensitivity CRP

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