Kolorektal Kanserin Anatomik Lokalizasyonun Belirlenmesinde İnflamatuar Belirteçler Faydalı Mıdır?: İmmatür Granulosit ve Kırmızı Hücre Dağılım Genişliği

Yıl 2025, Cilt: 6 Sayı: 3, 157 - 165, 28.09.2025

Ümit Özdemir , Necip Tolga Baran

https://doi.org/10.47482/acmr.1627472

Öz

Arka Plan: Sağ ve sol kolon tümörleri arasında embriyolojik, klinikopatolojik ve prognostik farklar bulunur. Bu çalışmanın amacı sağ ve sol kolon kanserlerinin ayrılmasında inflamatuar belirteçlerin tanısal faydasının araştırılmasıdır.
Yöntemler: Hastalar sağ kolon kanseri(RCC) n=71 ((33.8%)) ve sol kolorektal kanser(LCRC) (n =139 (66.2%)) olarak ikiye ayrıldı. Klinik özellikler, hemoglobin, nötrofil lenfosit oranı (NLR), platelet lenfosit oranı(PLR), Sistemik İmmün-inflamasyon İndeksi(SII), İmmatür Granulosit sayısı(IGC), İmmatür Granulosit yüzdesi (IG%), Kırmızı Hücre Dağılım Genişliği yüzdesi (RDW) parametreleri gruplar arasında karşılaştırıldı.
Bulgular: Karşılaştırmada TNM evresi, NLR, PLR, SII, IGC ve IG% gruplar arasında benzerdir. RCC grubunda, hemoglobin düşük (11.35 (6.40 – 16.40) vs 13.00 (6.00 – 17.00) mg/dl), RDW yüksektir (14.80 %(11.90 – 27.90) vs 13.70% (11.00 – 37.10)), p=0.001 ve p=0.005 sırasıyla. ROC analizi hemoglobin(p<0.001, AUC=0.640) ve RDW% (p=0.004, AUC=0.621) açısından anlamlıdır
Sonuçlar: CRC’nin anatomik lokalizasyonu göstermede daha önce araştırılmış NLR, PLR ve ilk kez araştırılan, umut vadeden SII, IGC gibi inflamatuar belirteçler yetersizdir. Fark gözlenen RDW ve hemoglobin ise RCC grubunda sıkça görülen subklinik kanamaya bağlanabilir.

Anahtar Kelimeler

kolorektal kanser , kolorektal kanser lokalizasyonu , inflamatuar belirteçler , immatür granulosit , kırmız hücre dağılım genişliği

Are Inflammatory Markers Useful in Determining The Anatomic Localisation of Colorectal Cancer? Immature Granulocytes and Red Cell Distributon Width.

Öz

Background: There are embryological, clinicopathlogical, and prognostic differences between right and left colon tumours. The aim of this study was to investigate the diagnostic benefit of inflammatory markers in the differentiation of right and left colon cancers.
Methods: Two groups of patients were formed as 71 (33.8%) with right colon cancer (RCC) and 139 (66.2%) with left colorectal cancer (LCRC). The groups were compared in respect of clinical characteristics, hemoglobin, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), immature granulocyte count (IGC), immature granulocyte percentage (IG%), and red blood cell distribution width percentage (RDW%).
Results: The TNM grade, and NLR, PLR, SII, IGC, and IG% values were similar in both groups. In the RCC group, hemoglobin was determined to be lower than in the LCRC group (11.35 [6.40-16.40] vs. 13.00 [6.00-17.00] mg/dl), and RDW was higher (14.80% [11.90-27.90] vs. 13.70% [11.00-37.10]) (p=0.001, p=0.005, respectively). In ROC analysis, hemoglobin (AUC:0.640, p<0.001) and RDW% (AUC:0.621, p=0.004) were determined to be significant.
Conclusion: Inflammatory markers such as NLR and PLR, which have been previously investigated, and SII and IGC, promising and examined for the first time, are insufficient to show the anatomic localization of CRC. However, differences were observed in RDW and hemoglobin and these may be associated with subclinical bleeding, which is frequently seen in RCC.

Anahtar Kelimeler

Colorectal Cancer , Colorectal Cancer Localisation , Inflammatory markers , Immature Granulocytes , Red Cell Distribution Width

Etik Beyan

No funds, grants, or other support was received. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. All authors declare that the study was conducted in accordance with the Declaration of Helsinki and followed the ethical standards of Türkiye. Approval was granted by the Ethics Committee of Ankara Etlik City Hospital (Date: 20.03.2024, No: AEŞH-BADEK-2024-238).

Kaynakça

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