Effects of Octreotid on Biliary, Pancreatic, and Enterocutaneous Fistulas

Yıl 1996, Cilt: 1 Sayı: 1, 28 - 30, 30.11.1996

Bahattin Dalkılıç Nuh Zafer Cantürk Cihan Yıldırır Nihat Zafer Utkan

Öz

Objective: Enterocutaneous, biliary or
pancreatic fistulas appearing after laparatomy are treated with the classical
methods or these plus octreotid. It has been suggested that subcutaneous
injections of octreotid diminish output from the fistula in all cases.

Methods: We evaluated our patients who
were treated by classical methods or those plus octreotid injection.

Results: Spontaneous fistula closure
occurred after 37.57±7. 06 days of treatment with classical treatment. The mean
hospital stay was 44.93±6.30 days and bowel function was restored to normal.
Those results for octreotid treatment were respectively 23.3±5.53 days and
32.85±6.32 days . When compared, fistula closure time, hospital stay period and
flow rate were not statistically different between both groups (p>0.05) .
Necessity of operation in both groups were significantly different (p<0.
05).

Conclusion: Our preliminary results
indicated that octreotid can promote healing of enterocutaneous fistula by
inhibiting gastrointestinal secretions.

Anahtar Kelimeler

Fistula, octreotid, Effects

Biliyer, Pankreatik ve Enterokutanöz Fistullerde Oktreotid Asetatın Etkisi

Öz

Amaç: Laparatomi
sonrası oluşan enterokutanöz, bilier ve pankreatik fistül gastrointestinal
sistemin istirahati ve parenteral beslenme gibi klasik tedaviler ya da buna
ilaveten oktreotid ile tedavi edilebilmektedir. Oktreotidin subkutan uygulaması
tüm olgularda fistül outputunu azalttığı bildirilmiştir.

Yöntem: Bizde
gastrointestinal sistemin istirahati ve parenteral beslenme gibi klasik
yöntemler veya buna ilaveten oktreotid uygulanan hastalarımızı inceledik.

Bulgular: Klasik
tedavi ile spontan fistül kapanma süresi ortalama 37,57±7,06 gün ve hastanede
kalış süresi ise 44,93±6,30 gün idi. Oysa bu değerler oktreotid ilave edilen
tedavi grubunda ise 23,3±5,53 ve 32,85±6,32 idi. Fistül kapanma zamanı, hastanede
kalış süresi ve debileri karşılaştırıldığında aralarında fark yoktu (p>0,
05). Cerrahi müdahele gereksinimi açısından gruplar arasında fark saptandı
(p<0, 05).

Sonuç: Sonuçlarımız
oktreotidin gastrointestinal sekrasyonu azaltarak enterokütan fistüllerde
iyileşmeyi kolaylaştırıcı bir ajan olduğunu düşündürmektedir.

Anahtar Kelimeler

Fistül, oktreotid, Biliyer

Kaynakça

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