Araştırma Makalesi
BibTex RIS Kaynak Göster

Kocaeli Yöresinde Koroner Kalp Hastalığı Risk Tayini

Yıl 1997, Cilt: 2 Sayı: 2, 39 - 42, 30.04.1997

Öz

Çalışmamızın amacı Kocaeli Bölgesinde yaşayan insanların ateroskleroz riskini saptamaktı. Bu yayın 448 kişinin sonuçlarını içeren çalışmanın birinci kısmını oluşturmaktadır. Çalışma grubumuz uzun vadede 5000 kişiyi kapsayacaktır. Total kolesterol, trigliserid, HDL-kolesterol, LDL-kolesterol, glukoz, albümin, ürik asit ve total bilirubin çalışma grubumuzda ölçülen parametrelerdi. Çalışmamızın çarpıcı sonuçlar; düşük HDL-kolesterol, yüksek vücud kitle indeksi, yüksek bel kalça oranı, kadın ve erkek trigliserid düzeyleri arasında dikkate değer bir fark bulgularıdır.

Kaynakça

  • Naito KH. Coronary artery disease and disorders of lipid metabolism. In: Slwnalwn JF, Roche J, eds. Clinical Chemistry. Missouri: Mosby; 1996:664-665.
  • Gopinathan V, Miller NJ, Milner AD, Rice-Evans CA. Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett. 1994;349(2):197-200. doi:10.1016/0014-5793(94)00666-0
  • Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991;53(1Suppl):373S-379S. doi:10.1093/ajcn/53.1.373S.
  • Halliwell B, Gutteridge JMC. Lipid Peroxidation a Radical Chain Reaction. In: Halliwell B, Gutteridge JMC, eds. Free Radicals in Biology and Medicine. Oxford: Calerendon Press; 1991.
  • McLean JW, Tomlinson JE, Kuang WJ, et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature. 1987;330(6144):132-7. doi:10.1038/330132a0
  • Scanu AM. Lipoprotein(a). A potential bridge between the fields of atherosclerosis and thrombosis. Arch Pathol Lab Med. 1988;112(10):1045-1047.
  • Scanu AM. Structural and functional polymorphism of lipoprotein(a): biological and clinical implications. Clin Chem. 1995;41(1):170-172.
  • Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232(4746):34-47. doi:10.1126/science.3513311
  • Berenson GS, Radhakrishnamurthy B, Srinivasan SR, Vijayagopal P, Dalferes ER Jr, Sharma C. Recent advances in molecular pathology. Carbohydrate-protein macromolecules and arterial wall integrity--a role in atherogenesis. Exp Mol Pathol. 1984;41(2):267-287. doi: 10.1016/0014-4800(84)90043-1
  • Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320(14):915-924. doi:10.1056/NEJM198904063201407
  • Slotte JP, Oram JF, Bierman EL. Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface. J Biol Chem. 1987;262(27):12904-12907.
  • Srinivasan SR, Berenson GS. Serum apolipoproteins A-I and B as markers of coronary artery disease risk in early life: the Bogalusa Heart Study. Clin Chem. 1995;41(1):159-164.
  • Anderson Young SA, Cockayne S. Clinical chemistry : concepts and applications. In: Anderson Young SA, Cockayne S, eds. Clinical chemistry : concepts and applications. Philadelphia: Saunders; 1993:199.
  • International Lipid Information Bureau. The Ilıb Lıpıd Handbook For Clınıcal Practıce. USA; 1995:4-5.
  • Mahley RW, Palaoğlu KE, Atak Z, et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res. 1995;36(4):839-859.
  • Hergenç G, Taga Y, Emerk K, Çırakoğlu B. Apolipoprotein E genotyping in Turkish myocardial infarction survivors and healthy controls. 1995;2(1):46-49.
  • Assmann G, Schulte H. Results and Conclusions of the Prospective Cardiovascular Munster (PROCAM) Study. In: Assmann G, ed. Lipid Metabolism Disorders and Coronary Heart Disease (completely revised second edition). Munchen: MMV Medizin Verlag; 1993:21-67.
  • Gopinathan V, Miller NJ, Milner AD, Rice-Evans CA. Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett. 1994;349(2):197-200. doi:10.1016/0014-5793(94)00666-0
  • Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991;53(1Suppl):373S-379S. doi: 10.1093/ajcn/53.1.373S

Coronary Heart Disease Risk Assesment in Kocaelı Region

Yıl 1997, Cilt: 2 Sayı: 2, 39 - 42, 30.04.1997

Öz

The aim of the study was to assess the atherosclerosis risk of people living in Kocaeli Region. This article gives the results of 448 people that were screened and reports the first part of the study that has already been completed. Our screening group will include about 5000 people in the long run. Total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, glucose, albumin, uric acid and total bilirubin were measured in our study group. The striking results of our study were: low HDL-Cholesterol (HDL-C), high BMI, high waist to hip ratio (w/h), significant difference in the mean value for triglycericles between the men und the women.

Kaynakça

  • Naito KH. Coronary artery disease and disorders of lipid metabolism. In: Slwnalwn JF, Roche J, eds. Clinical Chemistry. Missouri: Mosby; 1996:664-665.
  • Gopinathan V, Miller NJ, Milner AD, Rice-Evans CA. Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett. 1994;349(2):197-200. doi:10.1016/0014-5793(94)00666-0
  • Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991;53(1Suppl):373S-379S. doi:10.1093/ajcn/53.1.373S.
  • Halliwell B, Gutteridge JMC. Lipid Peroxidation a Radical Chain Reaction. In: Halliwell B, Gutteridge JMC, eds. Free Radicals in Biology and Medicine. Oxford: Calerendon Press; 1991.
  • McLean JW, Tomlinson JE, Kuang WJ, et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature. 1987;330(6144):132-7. doi:10.1038/330132a0
  • Scanu AM. Lipoprotein(a). A potential bridge between the fields of atherosclerosis and thrombosis. Arch Pathol Lab Med. 1988;112(10):1045-1047.
  • Scanu AM. Structural and functional polymorphism of lipoprotein(a): biological and clinical implications. Clin Chem. 1995;41(1):170-172.
  • Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232(4746):34-47. doi:10.1126/science.3513311
  • Berenson GS, Radhakrishnamurthy B, Srinivasan SR, Vijayagopal P, Dalferes ER Jr, Sharma C. Recent advances in molecular pathology. Carbohydrate-protein macromolecules and arterial wall integrity--a role in atherogenesis. Exp Mol Pathol. 1984;41(2):267-287. doi: 10.1016/0014-4800(84)90043-1
  • Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320(14):915-924. doi:10.1056/NEJM198904063201407
  • Slotte JP, Oram JF, Bierman EL. Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface. J Biol Chem. 1987;262(27):12904-12907.
  • Srinivasan SR, Berenson GS. Serum apolipoproteins A-I and B as markers of coronary artery disease risk in early life: the Bogalusa Heart Study. Clin Chem. 1995;41(1):159-164.
  • Anderson Young SA, Cockayne S. Clinical chemistry : concepts and applications. In: Anderson Young SA, Cockayne S, eds. Clinical chemistry : concepts and applications. Philadelphia: Saunders; 1993:199.
  • International Lipid Information Bureau. The Ilıb Lıpıd Handbook For Clınıcal Practıce. USA; 1995:4-5.
  • Mahley RW, Palaoğlu KE, Atak Z, et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res. 1995;36(4):839-859.
  • Hergenç G, Taga Y, Emerk K, Çırakoğlu B. Apolipoprotein E genotyping in Turkish myocardial infarction survivors and healthy controls. 1995;2(1):46-49.
  • Assmann G, Schulte H. Results and Conclusions of the Prospective Cardiovascular Munster (PROCAM) Study. In: Assmann G, ed. Lipid Metabolism Disorders and Coronary Heart Disease (completely revised second edition). Munchen: MMV Medizin Verlag; 1993:21-67.
  • Gopinathan V, Miller NJ, Milner AD, Rice-Evans CA. Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett. 1994;349(2):197-200. doi:10.1016/0014-5793(94)00666-0
  • Cutler RG. Antioxidants and aging. Am J Clin Nutr. 1991;53(1Suppl):373S-379S. doi: 10.1093/ajcn/53.1.373S
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Alper Uzun Bu kişi benim

Tülin Özsüllü Bu kişi benim

Gülay Hergenç Bu kişi benim

Hale Maral Bu kişi benim

Ahmet Bayrak Bu kişi benim

Pınar Çetinalp Bu kişi benim

Nurhan Gürakan Bu kişi benim

Yayımlanma Tarihi 30 Nisan 1997
Gönderilme Tarihi 10 Ocak 1997
Yayımlandığı Sayı Yıl 1997 Cilt: 2 Sayı: 2

Kaynak Göster

AMA Uzun A, Özsüllü T, Hergenç G, Maral H, Bayrak A, Çetinalp P, Gürakan N. Coronary Heart Disease Risk Assesment in Kocaelı Region. Acta Med Nicomedia. Nisan 1997;2(2):39-42.

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