Öz
Carcinoma of the colorectum are the third most common malignancy after skin and lung carcinoma. They occur approxima-tely eçually among males and females. The most common site of distant metastatic disease is the liver, follovved by lung. The locoregional failure risk for colonic carcinomas is substantially less than that of eçuivalant rectal cancers. Skin metastases is rarely seen in patients with carcinoma of the colorectum and indicates poor prognosis. Our case was a 27 years old female pati-ent. She had right hemicolectomy on may 2001. She had multiple recurrenses from march 2002 until february 2007. Our case is interresting because of its history and long term survival obtained with agressive therapy approaches consisted of surgery, chemotherapy and radiationtherapy.
Anahtar Kelimeler
Colonic carcinoma locoregional recurrences distant metastases.
Kaynakça
- Minsky BD, Mies C, Rich TA, et al. Poterıtially curative sur- gery of colon cancer: Patterns o f failure and survival. J Clin Oncol 1988;6:106-18.
- VVİllert CG, Teper JE, Cohen AM, et al. Failure patterns fol- lowing curative resection o f colonic carcinoma. Ann Surg 1984;200:685-90.
- Calvo FA, Viera JC, Gunderson LL, VVİllett CG. Cancer o f the
- Pancreas: Perez CA, Brady LW, Principles and Practice of Radiation Oncology, 4,h ed. Philadelphia J.B. Lippincott, 2004:1574-88.
- Sarid D, VVİgler N, Gutkin Z, Merimsky O, Leider-Trejo L,
- Ron IG. Cutaneous and subcutaneous metastases o f rectal cancer. Int J Clin Oncol. 2004; 9:202-205.
- Kilickap S, Aksoy S, Dincer M, Sağlam EA, Yalcin S. Cutaneous metastases of signet celi carcinoma of the rec- tum vvithout accompanying visceral involvement. South Med J 2006;99:1137-9.
- Torzilli G, Cremascoli G, Cattaneo S, Stefanini P, Olivari N.
- Drain-site tumour recurrence after laparotomy resection for colorectal cancer. E u rJ Surg Oncol 1999;25:546-7.
- Landis SH, Murray T, Bolden S, et al. Cancer statistics , 1998. CA Cancer J Clin 1998;48:6-29.
- Moertel CG, Fleming TR, MacDonald JS, et al. Levamisole
- and fluorourasil for adjuvant therapy o f resected colon car cinoma. N Engl J Med 1990;322-52.
- Moertel CG, Fleming TR, MacDonald JS, et al. Fluorourasil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report. Ann Intern Med 1995:122:321.
- O'Connell MJ, Laurie JA, Kahn M, et al. Prospectively ran- domized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer. J CUn Oncol 1998;16:295-300.
- Matterson J, Willert C, Sargent D, et al. A Phase III Study of Adjuvant Radiation Therapy (RT), 5-Fluorourasil(5-FU), and Levamisole(LEV) vs. 5-FU and LEV in Selected Patients with Resected, High Risk Colon Cancer: Initial Results of Int 0130. ProcAnnual M eetAm Soc Clin Oncol 1999;18:A904.
Öz
Kolorektal kanserler cilt ve akciğer kanserlerinden sonra en sık görülen kötü huylu tümörlerdir. Erkek ve kadınlarda yaklaşık benzer sıklıkta görülürler. Kolon kanserinde en sık görülen uzak metastaz bölgesi karaciğerdir; bunu akciğerler takip eder, lokal ve bölgesel nüks riski aynı evredeki rektum kanserine göre daha azdır. Kolorektal kanserlerde cilt metastazı nadirdir, genellikle uzak metastaza bağlıdır ve kötü prognoza sahiptir. Sunulan olgu 27 yaşında kadın hasta olup Mayıs 2001 yılında kolon adeno kanseri tanısı ile sağ hemikolektomi uygulanmıştı. 2002 yılında karın cildi metastazı ile başvuran hasta bu tarihten itibaren çok sayıda nükslerle 2007 yılı Şubat ayına kadar takibimizde idi, değişik seyri ve rekürrenslerinde uygulanan cerrahi, kemoterapi ve radyoterapiyi içeren kombine tedavi yaklaşımları ile uzun süreli sağkalım göstermesi nedeniyle olgu olarak sunuldu.
Anahtar Kelimeler
Kaynakça
- Minsky BD, Mies C, Rich TA, et al. Poterıtially curative sur- gery of colon cancer: Patterns o f failure and survival. J Clin Oncol 1988;6:106-18.
- VVİllert CG, Teper JE, Cohen AM, et al. Failure patterns fol- lowing curative resection o f colonic carcinoma. Ann Surg 1984;200:685-90.
- Calvo FA, Viera JC, Gunderson LL, VVİllett CG. Cancer o f the
- Pancreas: Perez CA, Brady LW, Principles and Practice of Radiation Oncology, 4,h ed. Philadelphia J.B. Lippincott, 2004:1574-88.
- Sarid D, VVİgler N, Gutkin Z, Merimsky O, Leider-Trejo L,
- Ron IG. Cutaneous and subcutaneous metastases o f rectal cancer. Int J Clin Oncol. 2004; 9:202-205.
- Kilickap S, Aksoy S, Dincer M, Sağlam EA, Yalcin S. Cutaneous metastases of signet celi carcinoma of the rec- tum vvithout accompanying visceral involvement. South Med J 2006;99:1137-9.
- Torzilli G, Cremascoli G, Cattaneo S, Stefanini P, Olivari N.
- Drain-site tumour recurrence after laparotomy resection for colorectal cancer. E u rJ Surg Oncol 1999;25:546-7.
- Landis SH, Murray T, Bolden S, et al. Cancer statistics , 1998. CA Cancer J Clin 1998;48:6-29.
- Moertel CG, Fleming TR, MacDonald JS, et al. Levamisole
- and fluorourasil for adjuvant therapy o f resected colon car cinoma. N Engl J Med 1990;322-52.
- Moertel CG, Fleming TR, MacDonald JS, et al. Fluorourasil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report. Ann Intern Med 1995:122:321.
- O'Connell MJ, Laurie JA, Kahn M, et al. Prospectively ran- domized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer. J CUn Oncol 1998;16:295-300.
- Matterson J, Willert C, Sargent D, et al. A Phase III Study of Adjuvant Radiation Therapy (RT), 5-Fluorourasil(5-FU), and Levamisole(LEV) vs. 5-FU and LEV in Selected Patients with Resected, High Risk Colon Cancer: Initial Results of Int 0130. ProcAnnual M eetAm Soc Clin Oncol 1999;18:A904.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2008 |
| Yayımlandığı Sayı | Yıl 2008 Cilt: 41 Sayı: 1 |