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Temporamandibuler Eklem Bozukluğu Olan Hastalarda Antidepresan İlaç Kullanım Öyküsü

Yıl 2025, Cilt: 4 Sayı: 3, 171 - 175, 30.12.2025
https://doi.org/10.62268/add.1757903

Öz

Amaç
Temporamandibular eklem rahatsızlıkları, toplumun büyük bir bölümünde görülen ve çeşitli etiyolojik faktörlere bağlı olarak gelişen bir sorundur. Stres ve anksiyete gibi ruhsal bozukluklar da bu faktörler arasındadır. Bu çalışmada, temporamandibular eklem problemi olan hastalarda antidepresan ilaç kullanım öyküsünün değerlendirilmesi ve stres, depresyon ve bu problem arasındaki olası ilişkinin araştırılması amaçlanmıştır.
Gereç ve Yöntemler
Bu çalışma, Kahramanmaraş Sütçü İmam Üniversitesi Diş Hekimliği Fakültesi Ağız Radyolojisi Anabilim Dalı'na başvuran hastalar üzerinde yürütülmüştür. Çalışmaya, kliniğimize TME şikayeti ile başvuran, 18-65 yaşları arasında toplam 200 hasta dahil edilmiştir. Bu hastalar yaş, cinsiyet ve antidepresan ilaç kullanıp kullanmadıklarına göre değerlendirilmiştir. İlaç kullanıcıları, aktif olarak kullananlar ve son 1 yıldır antidepresan ilaç kullanmayan ancak geçmişte bir dönem kullanmış olanlar olarak gruplandırılmıştır.
Bulgular
TME şikayeti ile başvuran toplam 200 hastanın 147'si (%73,5) kadın, 53'ü (%26,5) erkekti. 59 hasta (%29,5) (48 kadın, 11 erkek) aktif olarak antidepresan kullanıyordu ve 35 hasta (%17,5) (25 kadın, 10 erkek) geçmişte bir süredir antidepresan kullanmıştı. 106 hasta (%53) ise geçmişte hiç antidepresan kullanmamıştı.
Sonuç
TME sorunları olan hastaların önemli bir kısmında antidepresan ilaç kullanım öyküsü vardı. Eklem şikayeti ile başvuran hastaların çoğunluğu kadındı. TME semptomları olan hastaların çoğunda stres ve anksiyete ana yatkınlık faktörleri olarak düşünülmelidir.

Etik Beyan

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Ethics committee approval was received for this study from Kahramanmaras Sütcü Imam University Faculty of Medicine Clinical Research Ethics Committee (14-2025/20).

Destekleyen Kurum

The author declared that this study has received no financial support.

Kaynakça

  • Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015; 91: 378-86.
  • Ouanounou A, Goldberg M, Haas DA. Pharmacotherapy in temporomandibular disorders: a review. J Can Dent Assoc. 2017; 83: 1-8.
  • Wright EF. Manual of temporomandibular disorders. John Wiley & Sons, Chichester, UK, 2014.
  • Buescher JJ. Temporomandibular joint disorders. Am Fam Physician. 2007; 76: 1477-82.
  • Maixner W, Diatchenko L, Dubner R, Fillingim RB, Greenspan JD, Knott C. Orofacial pain prospective evaluation and risk assessment study - the OPPERA study. J Pain. 2011; 12: 4-11.
  • Cascos-Romero J, Vázquez-Delgado E, Vázquez-Rodríguez E, Gay-Escoda C. The use of tricyclic antidepressants in the treatment of temporomandibular joint disorders: a systematic review of the literature of the last 20 years. Med Oral Patol Oral Cir Bucal. 2009; 14: 3-7.
  • Martorell-Calatayud L, García-Mira B, Peñarrocha-Diago M. Orofacial pain management: an update. Med Oral Organo Soc Espanola Med Oral Acad Iberoam Patol Med Bucal. 2004; 9: 293-9.
  • Okeson JP. The American Academy of orofacial pain: orofacial pain guidelines for assessment, diagnosis, and management. Quintessence Publ Co Inc Chic. 1996; 113-84.
  • Schimelpfening N. The 5 Major Classes of Antidepressants. 2018.
  • Trindade E, Menon D, Topfer LA, Coloma C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ. 1998; 159: 1245-52.
  • McQuay HJ, Moore RA. Antidepressants and chronic pain: effective analgesia in neuropathic pain and other syndromes. BMJ. 1997; 314: 763-7.
  • Preskorn SH, Stanga CY, Feighner JP, Ross R. Antidepressants: past, present and future. In: Preskorn SH, Feighner JP, Stanga CY, Ross R, editors. Antidepressants: Past, Present and Future. Berlin, Springer, 2004.
  • Edinoff AN, Akuly HA, Hanna TA, Ochoa CO, Patti SJ, Ghaffar YA. Selective serotonin reuptake inhibitors and adverse effects: a narrative review. Neurol Int. 2021; 13: 387-401.
  • Wroclawski C, Mediratta JK, Fillmore WJ. Recent advances in temporomandibular joint surgery. Medicina (Mex). 2023; 59: 1409.
  • Wieckiewicz M, Boening K, Wiland P, Shiau YY, Paradowska Stolarz A. Reported concepts for the treatment modalities and pain management of temporomandibular disorders. J Headache Pain. 2015; 16: 106.
  • Fernandes G, Gonçalves DA, de Siqueira JT, Camparis CM. Painful temporomandibular disorders, self reported tinnitus, and depression are highly associated. Arq Neuropsiquiatr. 2013; 71: 943-7.
  • Garstka AA, Kozłowska L, Kijak K, Brzózka M, Gronwald H, Skomro P. Accurate diagnosis and treatment of painful temporomandibular disorders: a literature review supplemented by own clinical experience. Pain Res Manag. 2023; 31: 1002235.
  • Manfredini D, Piccotti F, Ferronato G, Guarda Nardini L. Age peaks of different RDC/TMD diagnoses in a patient population. J Dent. 2010; 38: 392-9.
  • Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Association between female hormonal factors and oro-facial pain: study in the community. Pain. 2002; 97: 5-10.
  • Ohrbach R, Dworkin SF. The evolution of TMD diagnosis: past, present, future. J Dent Res. 2016; 95: 1093-101.
  • Kindler S, Samietz S, Houshmand M, et al. Depressive and anxiety symptoms as risk factors for temporomandibular joint pain: a prospective cohort study in the general population. J Pain. 2012; 13: 1188-97.
  • Slade GD, Ohrbach R, Greenspan JD, et al. Painful temporomandibular disorder: decade of discovery from OPPERA studies. J Dent Res. 2016; 95: 1084-92.
  • Manfredini D, Winocur E, Guarda-Nardini L. Epidemiology of bruxim in adults: a systematic review of the literature. J Orofacial Pain. 2013; 27: 99-110.
  • Restrepo CC, Vásquez LM, Alvarez M, Valencia I. Personality traits and temporomandibular disorders in a group of children with bruxing behaviour. J Oral Rehabil. 2008; 35: 585-93.
  • Bonjardim LR, Gavião MBD, Pereira LJ, Castelo PM. Anxiety and depression in adolescents and their relationship with signs and symptoms of temporomandibular disorders. Int J Prosthodont. 2005; 18: 347-52.
  • Uca AU, Uguz F, Kozak HH, Gümüs H, Aksoy F, Seyithanoglu A. Antidepressant-induced sleep bruxism: prevalence, incidence, and related factors. Clin Neuropharmacol. 2015; 38: 227-30.
  • Garrett AR, Hawley JS. SSRI-associated bruxism: a systematic review of published case reports. Neurol Clin Pract. 2018; 8: 135-41.

History of Antidepressant Drug Use in Patients with Temporomandibular Joint Disorder

Yıl 2025, Cilt: 4 Sayı: 3, 171 - 175, 30.12.2025
https://doi.org/10.62268/add.1757903

Öz

Objectives
Temporomandibular joint disorders are a problem seen in a large part of the population and develop due to various etiological factors. Mental disorders such as stress and anxiety are also among these factors. This study aimed to evaluate the history of antidepressant medication use in patients with temporomandibular joint problems and to investigate the possible relationship between stress and depression and this problem.
Material and Methods
This study was conducted on patients admitted to the Department of Oral Radiology, Faculty of Dentistry, Kahramanmaraş Sütçü Imam University. A total of 200 patients between the ages of 18-65 years and presenting to our clinic with any symptom of TMJ complaints were included in the study. These patients were evaluated according to age, gender and whether or not they were taking antidepressant medication. Drug users were grouped as current active users and those who had not used antidepressant drugs for the last 1 year but had used them at some time in the past.
Results
Of a total of 200 patients presenting with TMJ complaints, 147 (73.5%) were female and 53 (26.5%) were male. Fifty nine (29.5%) patients (48 females, 11 males) were actively using antidepressants and 35 (17.5%) patients (25 females, 10 males) had used antidepressants for some time in the past. One hundred six (53%) patients had never used antidepressants in the past.
Conclusion
A significant proportion of patients with TMJ problems had a history of antidepressant medication use. The majority of the patients presenting with joint complaints were women. Stress and anxiety should be considered as the main predisposing factors in the majority of patients with TMJ symptoms.

Etik Beyan

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Ethics committee approval was received for this study from Kahramanmaras Sütcü Imam University Faculty of Medicine Clinical Research Ethics Committee (14-2025/20).

Destekleyen Kurum

The author declared that this study has received no financial support.

Kaynakça

  • Gauer RL, Semidey MJ. Diagnosis and treatment of temporomandibular disorders. Am Fam Physician. 2015; 91: 378-86.
  • Ouanounou A, Goldberg M, Haas DA. Pharmacotherapy in temporomandibular disorders: a review. J Can Dent Assoc. 2017; 83: 1-8.
  • Wright EF. Manual of temporomandibular disorders. John Wiley & Sons, Chichester, UK, 2014.
  • Buescher JJ. Temporomandibular joint disorders. Am Fam Physician. 2007; 76: 1477-82.
  • Maixner W, Diatchenko L, Dubner R, Fillingim RB, Greenspan JD, Knott C. Orofacial pain prospective evaluation and risk assessment study - the OPPERA study. J Pain. 2011; 12: 4-11.
  • Cascos-Romero J, Vázquez-Delgado E, Vázquez-Rodríguez E, Gay-Escoda C. The use of tricyclic antidepressants in the treatment of temporomandibular joint disorders: a systematic review of the literature of the last 20 years. Med Oral Patol Oral Cir Bucal. 2009; 14: 3-7.
  • Martorell-Calatayud L, García-Mira B, Peñarrocha-Diago M. Orofacial pain management: an update. Med Oral Organo Soc Espanola Med Oral Acad Iberoam Patol Med Bucal. 2004; 9: 293-9.
  • Okeson JP. The American Academy of orofacial pain: orofacial pain guidelines for assessment, diagnosis, and management. Quintessence Publ Co Inc Chic. 1996; 113-84.
  • Schimelpfening N. The 5 Major Classes of Antidepressants. 2018.
  • Trindade E, Menon D, Topfer LA, Coloma C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. CMAJ. 1998; 159: 1245-52.
  • McQuay HJ, Moore RA. Antidepressants and chronic pain: effective analgesia in neuropathic pain and other syndromes. BMJ. 1997; 314: 763-7.
  • Preskorn SH, Stanga CY, Feighner JP, Ross R. Antidepressants: past, present and future. In: Preskorn SH, Feighner JP, Stanga CY, Ross R, editors. Antidepressants: Past, Present and Future. Berlin, Springer, 2004.
  • Edinoff AN, Akuly HA, Hanna TA, Ochoa CO, Patti SJ, Ghaffar YA. Selective serotonin reuptake inhibitors and adverse effects: a narrative review. Neurol Int. 2021; 13: 387-401.
  • Wroclawski C, Mediratta JK, Fillmore WJ. Recent advances in temporomandibular joint surgery. Medicina (Mex). 2023; 59: 1409.
  • Wieckiewicz M, Boening K, Wiland P, Shiau YY, Paradowska Stolarz A. Reported concepts for the treatment modalities and pain management of temporomandibular disorders. J Headache Pain. 2015; 16: 106.
  • Fernandes G, Gonçalves DA, de Siqueira JT, Camparis CM. Painful temporomandibular disorders, self reported tinnitus, and depression are highly associated. Arq Neuropsiquiatr. 2013; 71: 943-7.
  • Garstka AA, Kozłowska L, Kijak K, Brzózka M, Gronwald H, Skomro P. Accurate diagnosis and treatment of painful temporomandibular disorders: a literature review supplemented by own clinical experience. Pain Res Manag. 2023; 31: 1002235.
  • Manfredini D, Piccotti F, Ferronato G, Guarda Nardini L. Age peaks of different RDC/TMD diagnoses in a patient population. J Dent. 2010; 38: 392-9.
  • Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Association between female hormonal factors and oro-facial pain: study in the community. Pain. 2002; 97: 5-10.
  • Ohrbach R, Dworkin SF. The evolution of TMD diagnosis: past, present, future. J Dent Res. 2016; 95: 1093-101.
  • Kindler S, Samietz S, Houshmand M, et al. Depressive and anxiety symptoms as risk factors for temporomandibular joint pain: a prospective cohort study in the general population. J Pain. 2012; 13: 1188-97.
  • Slade GD, Ohrbach R, Greenspan JD, et al. Painful temporomandibular disorder: decade of discovery from OPPERA studies. J Dent Res. 2016; 95: 1084-92.
  • Manfredini D, Winocur E, Guarda-Nardini L. Epidemiology of bruxim in adults: a systematic review of the literature. J Orofacial Pain. 2013; 27: 99-110.
  • Restrepo CC, Vásquez LM, Alvarez M, Valencia I. Personality traits and temporomandibular disorders in a group of children with bruxing behaviour. J Oral Rehabil. 2008; 35: 585-93.
  • Bonjardim LR, Gavião MBD, Pereira LJ, Castelo PM. Anxiety and depression in adolescents and their relationship with signs and symptoms of temporomandibular disorders. Int J Prosthodont. 2005; 18: 347-52.
  • Uca AU, Uguz F, Kozak HH, Gümüs H, Aksoy F, Seyithanoglu A. Antidepressant-induced sleep bruxism: prevalence, incidence, and related factors. Clin Neuropharmacol. 2015; 38: 227-30.
  • Garrett AR, Hawley JS. SSRI-associated bruxism: a systematic review of published case reports. Neurol Clin Pract. 2018; 8: 135-41.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ağız, Diş ve Çene Radyolojisi
Bölüm Araştırma Makalesi
Yazarlar

Mehmet Numan Köse 0000-0002-2487-1885

Emine Ararat 0000-0002-2383-373X

Gönderilme Tarihi 4 Ağustos 2025
Kabul Tarihi 27 Ekim 2025
Yayımlanma Tarihi 30 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 4 Sayı: 3

Kaynak Göster

Vancouver Köse MN, Ararat E. History of Antidepressant Drug Use in Patients with Temporomandibular Joint Disorder. Akd Dent J. 2025;4(3):171-5.

Başlangıç: 2022

Yayın Aralığı: Yılda 3 sayı

Yayıncı: Akdeniz Üniversitesi