Trabzon ve çevre illerde sentetik kannabinoid kullanan olguların değerlendirilmesi

Yıl 2017, Cilt: 31 Sayı: 2, 45 - 52, 31.08.2017

Hülya Karadeniz Hamide Elvan Bayrak Özgür Tuna Coşkun Şahin Fatih Çakıroğlu Anıl Ece Arslan

https://izlik.org/JA32FR79SL

Öz

AMAÇ: Sentetik kannabinoidler SK kannabinoid reseptörleri üzerinde agonistik etki gösteren ve kannabisin aktif metaboliti olan Δ9-tetrahidrokannabinole Δ9-THC benzer etkileri olan psikoaktif maddelerdir. Son yıllarda özellikle internet üzerinden satışların yoğunlaşması bu maddelere ulaşımı kolaylaştırmış olup, ciddi bir tehlike haline gelmesine neden olmuştur.YÖNTEM: Adli Tıp Kurumu Trabzon Grup Başkanlığı Kimya İhtisas Dairesi Toksikoloji Şubesine 1 Ocak 2013 ve 31 Aralık 2014 yıllarında uyuşturucu kullanımı şüphesiyle yakalanan olgulardan alınan kan ve idrar numunelerinin Sıvı Kromatografi Kütle/Kütle Spektrometri LC–MS/MS cihazı ile analiz sonrasında elde edilen sonuçlar ve olguların sosyodemografik özellikleri retrospektif olarak değerlendirildi. BULGULAR: SK kullandığı tespit edilen 291 olgunun 280’i %96,2 erkek, 11’i %3.8 kadındı. Erkeklerin yaş ortalaması 26.1±9.5, kadınların yaş ortalaması 22.1±6.9’du. Olguların 78’inde %26.8 sadece JWH-018 ve JWH-073’ün metabolitleri tespit edilirken, 213’ünde SK ile birlikte diğer maddelerde esrar, ekstazi, eroin, kokain, benzodiazepin, antidepresan, antipsikotik tespit edildi. SONUÇ: SK kullanımının erkekler arasında yaygın olduğunu ve kullanıcıların büyük çoğunluğunun adölesanlar ve genç erişkin olup, eğitim düzeylerinin düşük olduğu söylenebilir. SK kullanımının en az esrar kadar yaygın olduğu görülmektedir.

Anahtar Kelimeler

Sentetik kannabinoid , kannabis , psikoaktif , adli toksikoloji

The evaluation of cases using synthetic cannabinoid in Trabzon and the surrounding provinces

https://izlik.org/JA32FR79SL

Öz

OBJECTIVE: Synthetic cannabinoids SC are psychoactive substances with effects similar to Δ9-tetrahydrocannabinol Δ9THC , which is an active metabolite of cannabis and which shows an agonistic effect on cannabinoid receptors. In recent years, as access to these substances has become easier with widespread sales over the Internet, it has now become a danger. METHODS: A retrospective evaluation was made of the sociodemographic characteristics of the cases and the results of blood and urine samples analyzed with a Liquid chromatography-tandem mass spectrometry LC-MS/MS device from cases suspected of drug use between 1 January 2013 and 31 December 2014, in the Toxicology Branch of the Chemistry Department of Trabzon Branch of The Council of Forensic Medicine.RESULTS: Of 291 cases determined with SC use, 280 96.2% were male and 11 3.8% were female. The mean age was 26.1±9.5 years in the males and 22.1±6.9 years in the females. While only JWH-018 and JWH-073 metabolites were determined in 78 26.8% cases, SC was determined together with other substances marijuana, ecstasy, heroin, cocaine benzodiazepine, anti-depressants, anti-psychotics in 213 cases.in 213 cases.CONCLUSION: SC use is widespread among males and the vast majority of users are adolescents and young adults with a low level of education.The use of SC was seen to be as widespread as that of cannabis.

Anahtar Kelimeler

Synthetic cannabinoid , cannabis , psychoactive , forensic toxicology

Kaynakça

• Yargıç İ. Synthetic cannabinoids. The Council of Forensic Medicine New-trend Psychoactive Substances Symposium. 26 November 2013:9-11. Available at: http://www.atk.gov.tr/ Pdf/psikoakifmaddeler.pdf cited: 5 March 2014 .
• Drummer O, Odell M. The Forensic Pharmacology Of Drugs Of Abuse. London: Arnold, 2001.
• Ashton CH. Pharmacology and effects of cannabis: A brief review. Br J Psychiatry 2001;178 2 :101-6.
• Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev ;58 3 :389-462.
• Ottani A, Giuliani D. HU 210: A potent tool for investigations of the cannabinoid system. CNS Drug Rev 2001;7 2 :131-45.
• Özşeker PE, Dip A, Dağlıoğlu N, Gülmen MK. Synthetic can- nabinoids: A new generation marihuana. Türk Aile Hek Derg ;21 1 :34-40.
• Seely KA, Lapoint J, Moran JH, Fattore L. Spice drugs are more than harmless herbal blends: A review of the pharma- cology and toxicology of synthetic cannabinoids. Prog Neu- ropsychopharmacol Biol Psychiatry 2012;39 2 :234-43.
• Vandrey R, Dunn KE, Fry JA, Girling ER. A survey study to characterize use of Spice products synthetic cannabinoids . Drug Alcohol Depend 2012;120:238-41.
• Recommended Methods for The Identification and Analysis of Synthetic Cannabinoid Receptor Agonists in Seized Materi- als, UNODC. Available at: http://www.unodc.org/documents/ scientific/STNAR48_Synthetic_Cannabinoids_ENG.pdf cited March 2014 .
• Akgül A, Aşıcıoğlu F. New Trends in Narcotic Substances and Early Warning System. In: Demir OÖ, Sever M. eds. Orga- nised Crime and New Trends [in Turkish]. Ankara: Polis Aca- demy Press; 2011. pp 29-56.
• Bertan A [Early Warning System]. Turkish Monitoring Centre for Drugs and Drug Addiction. 2010;188-90.
• Turkish Monitoring Centre for Drugs and Drug Addiction TUBIM National Report 2013.
• Council of Ministers Decision. Turkish Official Journal 02.2015; 29259.
• Elsohly MA, Gul W, Wanas AS, Radwan MM. Synthetic can- nabinoids: Analysis and metabolites. Life Sci 2014;97 1 :78-90.
• Evren C, Bozkurt M. Synthetic cannabinoids: Crisis of re- cent years [in Turkish]. Düşünen Adam The Journal of Psychi- atry and Neurological Sciences 2013;26 1 :1-11.
• Başak AS. Analysis of psychoactive substances and expertise. The Council of Forensic Medicine New-trend Psychoactive Subs- tances Symposium. 26 November 2013:5-6. Available at: http:// www.atk.gov.tr/Pdf/psikoakifmaddeler.pdf cited: 5 March 2014 .
• Perspectives on drugs, synthetic cannabinoids in Europe, EMCDDA. Available at: http://www.emcdda.europa.eu/attac- hements.cfm/att_212361_EN_EMCDDA_POD_2016_Synthe- tic%20cannabinoids.pdf cited 31 May 2016 .
• Vardakou I, Pistos C, Spiliopoulou Ch. Spice drugs as a new trend: Mode of action, identification and legislation. Toxi- col Lett 2010;197:157-62.
• Bozkurt M, Umut G, Evren C, Karabulut V. Clinical charac- teristics and laboratory test results of patients admitted to outpatient clinic for synthetic cannabinoid usage. J Psychiatry and Neurological Sciences 2014;27:328-34.
• Hu X, Primack BA, Barnett TE, Cook RL. College students and the use of K2: An emerging drug of abuse in young- per- sons. Subst Abuse Treat Prev Policy 2011;6 1 :16-7.
• Hoyte CO, Jacob J, Monte AA, Al-Jumaan M. Bronstein AC, Heard KJ. A characterization of synthetic cannabinoid ex- posures reported to the national poison data system in 2010. Ann Emerg Med 2012;60 4 ;435-8.
• Barratt MJ, Cakic V, Lenton S. Patterns of synthetic canna- binoid use in Australia. Drug Alcohol Rev 2013;32:141-6.
• Küçük E, Küçük İ, Kirazaldı YY. A new threat in the emer- gency department: Synthetic cannabinoids Bonzai, Jameika . Medical Journal of Selcuk 2015;25:18-22.
• Mutlu E, Alnıak İ, Aksoy UM, Erkıran M. The use of synthetic cannabinoids among probation population. Turkish Journal of Forensic Medicine 2015;29 3 :169-78.
• Yılmaz K, Yalçın M, Çakmakcı H, Bektemür G, Egici MT, Leblebici Y. Emergency service bonzai of patients presenting with use socio-demographic characteristics evaluated retros- pectively. J Academic Res in Nurs 2015;1 2 :80-5.
• European Monitoring Centre for Drugs and Drug Addiction. European drug report 2017: Trends and developments. Luxembourg: Publications Office of the European Union; 2017:1–96. Available at: http://www.emcdda.europa.eu/publications/edr/trends-developments/2017 cited: June 2014 .
• Fattore L, Fratte W. Beyond THC: The new generation of can- nabinoid designer drugs. Front Behav Neurosci 2011;5:1-12.
• Hutter M, Kneisel S, Auwarter V. Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterans in her- bal mixtures using LC-MS/MS techniques. J Mass Spectrom ;47:54-65.
• United Nations Office on Drugs and Crime UNODC . Synthetic Cannabinoids in Herbal Products. Available at: https://www.unodc.org/documents/scientific/Synthetic_Can- nabinoids.pdf cited: 22 November 2016
• AAPCC Issues Statement on the Synthetic Drug Abu- se Prevention Act. American Association of Poison Control Centre. Available at: http://www.aapcc.org/press/2 cited: 22 November 2016 .
• Wood KE. Exposure to bath salts and synthetic tetrahydro- cannabinoid from 2009 to 2012 in the United States. J Pediatr ;163:213-6.
• Zazoğlu S, Savaş H, Ketenci HÇ, Beyhun NE. A description of the profile of narcotics and new generation psychoactive substances sent by the judicial authorities to the Turkish Co- uncil of Forensic Medicine Trabzon Group Chairmanship bet- ween 2010 and 2014. J For Med 2017;31 1 :1-5.