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Travma dışı aort rüptürüne bağlı ölümlerin değerlendirilmesi

Yıl 2021, Cilt: 35 Sayı: 3, 120 - 137, 31.12.2021
https://izlik.org/JA92JP69WJ

Öz

AMAÇ: Bu çalışmanın amacı travma dışı aort rüptürü sonucu öldüğü tespit edilmiş olguların otopsi bulguları, organların histopatolojik özellikleri, anevrizma lokalizasyonu ve risk faktörlerini değerlendirmektir. YÖNTEM: 01.01.2015 - 31.12.2019 tarihleri arasında Adli Tıp Kurumu Morg İhtisas Dairesi tarafından travma dışı aort rüptürü nedeniyle öldüğü tespit edilen 250 vaka çalışmaya dahil edilmiştir. BULGULAR: Vakalardaki erkek kadın oranı 3,03: 1, yaş ortalaması 52,7±15,9’dur. Kadınların yaş ortalaması erkeklere göre anlamlı olarak daha yüksek bulunmuştur. En sık görülen yaş grubu 51-60 yaş grubu %24,4 olarak saptanmıştır. Vakaların vücut kitle indeksi ortalaması 28,9±6,2 olup, kadınlarda erkeklere göre biraz daha yüksek bulunmuştur. Tıbbi özgeçmişlerine erişilebilen vakaların %42,8’inde hipertansiyon olduğu tespit edilmiştir. Ayrıca vakaların %50’sinde ateroskleroz olduğu görülmüştür. Bir vakada Turner Sendromu olduğu öğrenilmiş olup, vakaların %4,4’ünde de biküspit aort kapakçığı tespit edilmiştir. Anevrizmaların lokalizasyonu incelendiğinde vakaların %55,6’sında anevrizmanın assendan aortta olduğu, %10,8’inde assendan aort ve arcus aortta olduğu tespit edilmiştir. Vakaların %78’inde rüptürün assendan aortta olduğu görülmüştür. DeBakey sınıflamasına göre vakaların %56,4’ünün Tip II, %11,6’sinin Tip I olduğu, %27,6’sının sınıflandırma dışında kaldığı tespit edilmiştir. Stanford sınıflamasına göre ise vakaların %88’inin Tip A, %8,9’unun Tip B diseksiyon olduğu, %3,1’inin ise sınıflandırma dışı kaldığı görülmüştür. SONUÇ: Travma dışı aort rüptürüne bağlı ölümlerin gerçek insidansını ve risk grubunda olan hastaları belirleyerek erken teşhis ve tedavi konusunda doğru stratejiler oluşturulması gerekmektedir.

Kaynakça

  • Şenel F. Malatya Turgut Özal Tıp Merkezi patoloji bölü- müne 2004-2005 yılları arasında gelen nedeni bilinmeyen ani ölüm vakalarının retrospektif değerlendirilmesi. İnönü Üniver- sitesi Tıp Fakültesi.2007;1-56. [in Turkish].
  • Temel N. Ani Ölümlerde Ateroskleroz Bulgularında Chlamydia Pneumoniae’nin Etkisinin Araştırılması, Ankara Üni- versitesi Adli Tıp Anabilim Dalı. Tıpta Uzmanlık Tezi. 2014. [in Turkish].
  • Basso C, Aguilera B, Banner J, Cohle S, d’Amati G, de Gouveia RH, et al. Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology. Virchows Archiv. 2017;471 6 :691-705.
  • Mendis S, Puska P, Norrving B, editors. Global at- las on cardiovascular disease prevention and control. Genava: World Health Organization WHO ; 2011.
  • Stecker EC, Reinier K, Marijon E, Narayanan K, Teo- dorescu C, Uy-Evanado A, et al. Public Health Burden Of Sudden Cardiac Death In The United States. Circulation: Arrhythmia and Electrophysiology. 2014;7 2 :212-7.
  • Türkiye İstatistik Kurumu Ölüm ve Ölüm Nedeni İstatistikleri, 2019 [cited:17.04.2021] Available from: https:// data.tuik.gov.tr/Bulten/Index?p=Olum-ve-Olum-Nedeni-Istatis- tikleri-2019-33710. [in Turkish].
  • Soysal Z, Eke SM, Çağdır AS. Adli Otopsi Cilt III, 1999, Doğal Nedenlere Bağlı Ani Ölümler, 1129-1141 p. [in Turkish].
  • Sarı H, Cansunar FN, Aşırdizer M, Yavuz MS, Akistan- bullu TF. Autopsy Findings in deaths caused by aortic aneurysm rupture. Haydarpaşa Bulletin of Cardiology and Cardiovascular Surgery. 1996;4:92-96.
  • Erbay AK, İstanbul İlinde 2015-2019 Yılları Arasında Otopsisi Yapılmış Ateşli Silah Yaralanmasına Bağlı Ölüm Olgularının Değerlendirilmesi, Uzmanlık Tezi; 2021. [in Turkish].
  • Çakır H, Evaluation of Sudden Cardiac Death in Forensic Autopsies Performed in Istanbul in 2019, Master Thesis; 2021.
  • World Health Organisation, Body Mass Index BMI [cited: 02.06.2021] Available from: https://www.euro.who.int/en/ health-topics/disease-prevention/nutrition/a-healthy-lifestyle/ body-mass-index-bmi.
  • Knight B. The Pathology of Sudden Death, Forensic Pathology Second Edition, London, 1997;504-505.
  • Bratzke H, Wojahn H. [The relevance of spontaneous ruptures of the aorta in forensic medicine author’s transl ]. Z Rechtsmed. 1977 Apr;79 3 :159–82.
  • Tüzün B, Elmas İ, Aşırdizer M, Akkay E. Evaluation of deaths due to ruptures of dissecting aorta aneurysm with respect to forensic medicine, İst.Tıp.Fak. Mecmuası 60:3,1997.
  • Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, et al. The International Registry of Acute Aortic Dissection IRAD . JAMA. 2000 Feb 16;283 7 :897.
  • Göktekin MÇ. A Retrospective Analysis of Patients With Aortic Dissection In The Emergency Unit, Van Medical Journal 26 1 :29-33, 2019.
  • Knuutinen A, Kokkonen N, Risteli J, Vähäkangas K, Kallioinen M, Salo T, et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002 Apr;146 4 :588–94.
  • Nordon IM, Hinchliffe RJ, Loftus IM, Thompson MM. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol. 2011 Feb;8 2 :92–102.
  • Hirst AEJ, Johns VJJ, Kime SWJ. Dissecting aneurysm of the aorta: a review of 505 cases. Medicine Baltimore . 1958 Sep;37 3 :217–79.
  • Brown LC, Powell JT. Risk factors for aneurysm rup- ture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg. 1999 Sep;230 3 :287–9.
  • Elefteriades JA, Olin JW, Halperin JL. Hurst’s The Heart, Chapter 106, 2261-2289 p.
  • Elefteriades JA, Olin JW, Halperin JL. Hurst’s The Heart, Chapter 106, 2261-2289 p.
  • Koşuyolu tecrübesi. Uzmanlık Tezi; 2007. [in Turkish]. and Contemporary Surgical Approaches. Turkiye Klinikleri J
  • Tunçer EY. Tip A Aort Diseksiyonunda 20 yıllık Koşuyolu tecrübesi. Uzmanlık Tezi; 2007. [in Turkish].
  • Ateş M, Akpınar MB, Okur FF, et al. Aortic Dissections and Contemporary Surgical Approaches. Turkiye Klinikleri J Cardiovasc Surg-Special Topics. 2012;4 1 :18-25.
  • Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. BMJ Case Rep. 2009;2009:bcr0620091998.
  • Singh K, Bønaa KH, Jacobsen BK, Bjørk L, Solberg S. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study : The Tromsø Study. Am J Epidemiol. 2001 Aug;154 3 :236–44.
  • Di Maio VJM, Dana SE. Handbook of Forensic Pathology, Chapter 5, 35-63 p.
  • Anagnostopoulos CE, Prabhakar MJS, Kittle CF. Aortic dissections and dissecting aneurysms. Am J Cardiol. 1972;30 3 :263–73.
  • Prakash SK, Haden-Pinneri K, Milewicz DM. Susceptibility to acute thoracic aortic dissections in patients dying outside the hospital: an autopsy study. Am Heart J. 2011 Sep;162 3 :474–9.
  • Albat B, Thevenet A. Dissecting aneurysms of the ascending aorta occurring late after aortic valve replacement. J Cardiovasc Surg Torino . 1992;33 3 :272–5.
  • Klintschar M, Bilkenroth U, Arslan-Kirchner M, Schmidtke J, Stiller D. Marfan syndrome: clinical consequences resulting from a medicolegal autopsy of a case of sudden death due to aortic rupture. Int J Legal Med. 2009 Jan;123 1 :55–8.
  • Bailey K, Duflou J, Puranik R. Fatal cases of aortic dissection: an autopsy study. Vol. 158, International journal of cardiology. Netherlands; 2012. p. 148–9.
  • Rashid J, Eisenbenrg MJ, Topol EJ. Cocaine-induced aortic dissection. Am Heart J. 1996;132 6 :1301-1304.
  • Perron AD, Gibbs M. Thoracic aortic dissection secondary to crack cocaine ingestion. Am J Emerg Med. 1997 Sep;15 5 :507–9.
  • Swalwell CI, Davis GG. Methamphetamine as a risk factor for acute aortic dissection. J Forensic Sci. 1999 Jan;44 1 :23–6.
  • Daily PO, Trueblood HW, Stinson EB, Wuerflein RD, Shumway NE. Management of Acute Aortic Dissections. Ann Thorac Surg. 1970 Sep;10 3 :237–47.
  • Raghupathy A, Nienaber CA, Harris KM, Myrmel T, Fattori R, Sechtem U, et al. Geographic differences in clinical presentation, treatment, and outcomes in type A acute aortic dissection from the International Registry of Acute Aortic Dissection . Am J Cardiol. 2008 Dec;102 11 :1562–6.
  • Trimarchi S, Eagle KA, Nienaber CA, Pyeritz RE, Jonker FHW, Suzuki T, et al. Importance of refractory pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection IRAD . Circulation. 2010 Sep;122 13 :1283–9.
  • Johnsen SH, Forsdahl SH, Singh K, Jacobsen BK. Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel? The Tromsø study. Arterioscler Thromb Vasc Biol. 2010 Jun;30 6 :1263–8.
  • Li Y, Li L, Mu H-S, Fan S-L, He F-G, Wang Z-Y. Aortic Dissection and Sudden Unexpected Deaths: A Retrospective Study of 31 Forensic Autopsy Cases. J Forensic Sci. 2015 Sep;60 5 :1206–11.

Evaluation of deaths due to non-traumatic aortic rupture

Yıl 2021, Cilt: 35 Sayı: 3, 120 - 137, 31.12.2021
https://izlik.org/JA92JP69WJ

Öz

INTRODUCTION: The aim of this study is to evaluate autopsy findings, histopathological features of organs, aneurysm localization and risk factors in non-traumatic aortic rupture death cases. METHODS: The data of 250 cases which determined to have died due to non-traumatic aortic rupture by the Morgue Department of Council of Forensic Medicine autopsy unit between 01.01.2015 and 12.31.2019 were included. RESULTS: The male-female ratio in the cases was 3.03: 1, and the mean age was 52.7±15.9 years. The mean age of women was found to be significantly higher than men. The most common age group was 51-60 age group 24.4% . The mean body mass index of the cases was 28.9±6.2, and it was found to be slightly higher in women than in men. Hypertension was found in 42.8% of the cases whose medical history could be accessed. In addition, 50% of the cases were found to have atherosclerosis. One case had Turner syndrome, and bicuspid aortic valve was detected in 4.4% of the cases. When the localization of the aneurysms was examined, 55.6% of the cases had the aneurysm in the ascending aorta, and 10.8% of the cases had in both the ascending aorta and arcus aorta. In 78% of the cases, the rupture was seen in the ascending aorta. According to the DeBakey classification, it was determined that 56.4% of the cases were Type II, 11.6% were Type I, and 27.6% were excluded from the classification. According to the Stanford classification, 88% of the cases were Type A, 8.9% were Type B dissection, and 3.1% were not classified. CONCLUSION: It is necessary to establish the right strategies for early diagnosis and treatment by determining the real incidence of deaths due to non-traumatic aortic rupture and the patients in the risk group.

Kaynakça

  • Şenel F. Malatya Turgut Özal Tıp Merkezi patoloji bölü- müne 2004-2005 yılları arasında gelen nedeni bilinmeyen ani ölüm vakalarının retrospektif değerlendirilmesi. İnönü Üniver- sitesi Tıp Fakültesi.2007;1-56. [in Turkish].
  • Temel N. Ani Ölümlerde Ateroskleroz Bulgularında Chlamydia Pneumoniae’nin Etkisinin Araştırılması, Ankara Üni- versitesi Adli Tıp Anabilim Dalı. Tıpta Uzmanlık Tezi. 2014. [in Turkish].
  • Basso C, Aguilera B, Banner J, Cohle S, d’Amati G, de Gouveia RH, et al. Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology. Virchows Archiv. 2017;471 6 :691-705.
  • Mendis S, Puska P, Norrving B, editors. Global at- las on cardiovascular disease prevention and control. Genava: World Health Organization WHO ; 2011.
  • Stecker EC, Reinier K, Marijon E, Narayanan K, Teo- dorescu C, Uy-Evanado A, et al. Public Health Burden Of Sudden Cardiac Death In The United States. Circulation: Arrhythmia and Electrophysiology. 2014;7 2 :212-7.
  • Türkiye İstatistik Kurumu Ölüm ve Ölüm Nedeni İstatistikleri, 2019 [cited:17.04.2021] Available from: https:// data.tuik.gov.tr/Bulten/Index?p=Olum-ve-Olum-Nedeni-Istatis- tikleri-2019-33710. [in Turkish].
  • Soysal Z, Eke SM, Çağdır AS. Adli Otopsi Cilt III, 1999, Doğal Nedenlere Bağlı Ani Ölümler, 1129-1141 p. [in Turkish].
  • Sarı H, Cansunar FN, Aşırdizer M, Yavuz MS, Akistan- bullu TF. Autopsy Findings in deaths caused by aortic aneurysm rupture. Haydarpaşa Bulletin of Cardiology and Cardiovascular Surgery. 1996;4:92-96.
  • Erbay AK, İstanbul İlinde 2015-2019 Yılları Arasında Otopsisi Yapılmış Ateşli Silah Yaralanmasına Bağlı Ölüm Olgularının Değerlendirilmesi, Uzmanlık Tezi; 2021. [in Turkish].
  • Çakır H, Evaluation of Sudden Cardiac Death in Forensic Autopsies Performed in Istanbul in 2019, Master Thesis; 2021.
  • World Health Organisation, Body Mass Index BMI [cited: 02.06.2021] Available from: https://www.euro.who.int/en/ health-topics/disease-prevention/nutrition/a-healthy-lifestyle/ body-mass-index-bmi.
  • Knight B. The Pathology of Sudden Death, Forensic Pathology Second Edition, London, 1997;504-505.
  • Bratzke H, Wojahn H. [The relevance of spontaneous ruptures of the aorta in forensic medicine author’s transl ]. Z Rechtsmed. 1977 Apr;79 3 :159–82.
  • Tüzün B, Elmas İ, Aşırdizer M, Akkay E. Evaluation of deaths due to ruptures of dissecting aorta aneurysm with respect to forensic medicine, İst.Tıp.Fak. Mecmuası 60:3,1997.
  • Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, et al. The International Registry of Acute Aortic Dissection IRAD . JAMA. 2000 Feb 16;283 7 :897.
  • Göktekin MÇ. A Retrospective Analysis of Patients With Aortic Dissection In The Emergency Unit, Van Medical Journal 26 1 :29-33, 2019.
  • Knuutinen A, Kokkonen N, Risteli J, Vähäkangas K, Kallioinen M, Salo T, et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002 Apr;146 4 :588–94.
  • Nordon IM, Hinchliffe RJ, Loftus IM, Thompson MM. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nat Rev Cardiol. 2011 Feb;8 2 :92–102.
  • Hirst AEJ, Johns VJJ, Kime SWJ. Dissecting aneurysm of the aorta: a review of 505 cases. Medicine Baltimore . 1958 Sep;37 3 :217–79.
  • Brown LC, Powell JT. Risk factors for aneurysm rup- ture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg. 1999 Sep;230 3 :287–9.
  • Elefteriades JA, Olin JW, Halperin JL. Hurst’s The Heart, Chapter 106, 2261-2289 p.
  • Elefteriades JA, Olin JW, Halperin JL. Hurst’s The Heart, Chapter 106, 2261-2289 p.
  • Koşuyolu tecrübesi. Uzmanlık Tezi; 2007. [in Turkish]. and Contemporary Surgical Approaches. Turkiye Klinikleri J
  • Tunçer EY. Tip A Aort Diseksiyonunda 20 yıllık Koşuyolu tecrübesi. Uzmanlık Tezi; 2007. [in Turkish].
  • Ateş M, Akpınar MB, Okur FF, et al. Aortic Dissections and Contemporary Surgical Approaches. Turkiye Klinikleri J Cardiovasc Surg-Special Topics. 2012;4 1 :18-25.
  • Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. BMJ Case Rep. 2009;2009:bcr0620091998.
  • Singh K, Bønaa KH, Jacobsen BK, Bjørk L, Solberg S. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study : The Tromsø Study. Am J Epidemiol. 2001 Aug;154 3 :236–44.
  • Di Maio VJM, Dana SE. Handbook of Forensic Pathology, Chapter 5, 35-63 p.
  • Anagnostopoulos CE, Prabhakar MJS, Kittle CF. Aortic dissections and dissecting aneurysms. Am J Cardiol. 1972;30 3 :263–73.
  • Prakash SK, Haden-Pinneri K, Milewicz DM. Susceptibility to acute thoracic aortic dissections in patients dying outside the hospital: an autopsy study. Am Heart J. 2011 Sep;162 3 :474–9.
  • Albat B, Thevenet A. Dissecting aneurysms of the ascending aorta occurring late after aortic valve replacement. J Cardiovasc Surg Torino . 1992;33 3 :272–5.
  • Klintschar M, Bilkenroth U, Arslan-Kirchner M, Schmidtke J, Stiller D. Marfan syndrome: clinical consequences resulting from a medicolegal autopsy of a case of sudden death due to aortic rupture. Int J Legal Med. 2009 Jan;123 1 :55–8.
  • Bailey K, Duflou J, Puranik R. Fatal cases of aortic dissection: an autopsy study. Vol. 158, International journal of cardiology. Netherlands; 2012. p. 148–9.
  • Rashid J, Eisenbenrg MJ, Topol EJ. Cocaine-induced aortic dissection. Am Heart J. 1996;132 6 :1301-1304.
  • Perron AD, Gibbs M. Thoracic aortic dissection secondary to crack cocaine ingestion. Am J Emerg Med. 1997 Sep;15 5 :507–9.
  • Swalwell CI, Davis GG. Methamphetamine as a risk factor for acute aortic dissection. J Forensic Sci. 1999 Jan;44 1 :23–6.
  • Daily PO, Trueblood HW, Stinson EB, Wuerflein RD, Shumway NE. Management of Acute Aortic Dissections. Ann Thorac Surg. 1970 Sep;10 3 :237–47.
  • Raghupathy A, Nienaber CA, Harris KM, Myrmel T, Fattori R, Sechtem U, et al. Geographic differences in clinical presentation, treatment, and outcomes in type A acute aortic dissection from the International Registry of Acute Aortic Dissection . Am J Cardiol. 2008 Dec;102 11 :1562–6.
  • Trimarchi S, Eagle KA, Nienaber CA, Pyeritz RE, Jonker FHW, Suzuki T, et al. Importance of refractory pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection IRAD . Circulation. 2010 Sep;122 13 :1283–9.
  • Johnsen SH, Forsdahl SH, Singh K, Jacobsen BK. Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel? The Tromsø study. Arterioscler Thromb Vasc Biol. 2010 Jun;30 6 :1263–8.
  • Li Y, Li L, Mu H-S, Fan S-L, He F-G, Wang Z-Y. Aortic Dissection and Sudden Unexpected Deaths: A Retrospective Study of 31 Forensic Autopsy Cases. J Forensic Sci. 2015 Sep;60 5 :1206–11.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Adli Biyoloji
Bölüm Araştırma Makalesi
Yazarlar

Mehmet Ali Dağ Bu kişi benim

Murat Nihat Arslan Bu kişi benim

Merve Temel Dağ Bu kişi benim

Muhammed Emin Gökşen Bu kişi benim

Gönderilme Tarihi 1 Ocak 2021
Yayımlanma Tarihi 31 Aralık 2021
IZ https://izlik.org/JA92JP69WJ
Yayımlandığı Sayı Yıl 2021 Cilt: 35 Sayı: 3

Kaynak Göster

Vancouver 1.Mehmet Ali Dağ, Murat Nihat Arslan, Merve Temel Dağ, Muhammed Emin Gökşen. Travma dışı aort rüptürüne bağlı ölümlerin değerlendirilmesi. ATD [Internet]. 01 Aralık 2021;35(3):120-37. Erişim adresi: https://izlik.org/JA92JP69WJ

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