Effects of Methamphetamine on Brain Catecholamines in Mice

Öz

We have investigated the changes in the mouse brain content of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine and the change in brain methamphetamine (MAP) concentration during an 8-hour period af ter administration of MAP (10 mg/kg). The levels of NE and DA were slightly elevated 0.5 hr af ter administration of MAP. The level of NE showed the minimum with a value of approx. 75 % of the control at 2.0 hT. The level of 5-HT was lowest approx. 45% 2.0 hr after the administration of MAP . MAP equilibrated rapidly; the peak brain MAP concentration was 27 flg/g 0.5 hr af ter drug administration.

Anahtar Kelimeler

• Methamphetamine
• Brain Catecholamines
• Mouse

Kaynakça

1. Greaves, G.B. (1980) Amphetamine & Related Stimulants: Chemical, Biological, Clinical & Sociological Aspects (Caldwell)., ed ) pp. 175 - 188, CRC Press, Boca Raton.
2. Trulson, M.E., Jacobs, B.L. (1979) J. Pharmacol. Exp. Ther., 211, 375 - 384.
3. Kuhn, C.M., Schanberg, S.M. (1978) J. Pharmacol. Exp. Ther., 207, 544 - 554.
4. Yoshimoto, K., Kano, A., Mizohata, K., Irizawa, Y., Komura, S. (1985) AdlfTıpDerg. (Istanbul), I, 247 - 285.
5. Yoshimoto, K. (1986) J. Kyoto Pref. Univ. Med., 95, 1693 - 1710.
6. Sasa, S., Blank, c.L. (1977) Anal. Chem., 49,354 - 359.
7. Mefford,I.N. (1981) J Neuroscience Methods,3, 207-224.
8. Yoshimoto, K., Komura, S., Kano, A., Mizohata, K. (1985) JRSC Med. Sci., 13, 1192 - 1193.

9. Lebish, P., Finkle, B.S., Brackett, V.W.Jr. (1970) Clin. Chem., 16, 195 - 200.
10. Tonge, S.R. (19.74) PsY.chopharmacology (Berlin), 38, 181 - 186.
11. Yamanaka, Y., Yamamoto, T., Egashira, T. (1983) Jpn . J. Pharmacol., 33, 33 - 40.
12. Seiden, L.S.; Fischman, M.W., Schuster, C.R. (1975n6) Drug Alcohol Depend., I, 215 - 219.
13. Wagner, G.c., Seiden, L.S., Schuster, C.R. (1974) Drug Alcohol Depend., 4, 435 - 438.