Araştırma Makalesi
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Laboratuvar Hayvanı Çalışmalarında İzlenecek Yol

Yıl 2003, Cilt: 17 Sayı: 1, 82 - 92, 30.04.2003
https://izlik.org/JA87RF84NN

Öz

Lahoratuar hayvanlal'l ile yapz/an ara§tlrmalann, hilgi uretiminde (jnemli hir yeri Hlrdlr. Lahoratuar hayvon1(//'1 ile yapllan herhangi hir ara§tlrmam/1 giil'enilir sonu~' vermesinde; lahoratuar ortamlllll1 kO§lIllan, ara.yttrll1(tCI/W1 yeterlillAi, sa,1lzklL ve huzurlu lahoraluar hayvanlan iizerinde ~'ah§zlmasl ve uygun tiir se('imi (jnl'lnli fakti)rler olarak slralanmaktadtr. Ara§tlrmal1l11 tiim a§anwlannda etik kurallara ve ilgili yasal diizen/emelere uyulmaslIIItl. etik kllrullara dal1l§llmasllun gerekti,1i hildirilmektedir. (j lkemizde adli hilimler alanznda, lahoratuar hayvanlan ile yapzla/1 deneysel ara§flrmalann saVlsf geIi.Jmi~· iilkelere gijre azdlr.
Bu yaZlda adli hilimler alal1/nda lahoratuar hayvanlan ile yapllacak ara§tlrmalann planlanmasl, riir s('(,·imi. ijlanazi uygulamast ve diseksiyol1 konulal'lnda hilgilerin sunu/f1wsl ama~)allmt§t/l'. Bil alandaki hi/gilerill riimiin/i 1m nwkalede vermek miimkiin olmasa da yararlanahilecek kaynaklar i~'in yol g(jsterici olahilmeye ~·ah.y!lmf~·flr. Uygul1 lahoratuar oUaml hulunmayan, ara§tlrmaCllW1 yeterli deneyiminin 01madl,11 ara~·tlrmalanl/, hem :aman. hem maliyet apsllldan kaYlp olu§turdu,1Imu df~§iil1mekteyiz. Bu nedeille I;a/t§z/acak lahoratuar ortam/am1ll1 dii:enlenmesi ve denetleme mekanizmaslyla korunmasl gerekmektedir. Aynca ara§tlrmactlarzn temel hilgi ve heeerile rill in artttnimasllw y(jnelik program/ara mezuniyet (jl1cesi ve sonraSl e,1itimde yer verilmesinin de hir zorun/IIluk oldu,~u giirii§iindeyiz.

Kaynakça

  • Poyraz O. Laboratuvar Hayvanlan Bilimi. Ankara: Kardelen Of set, 2000: 3-81.
  • Some research alternatives to animal testing. Eri~im: http://www.bxscience.edu/-grollman/gallery/research.htmIEri~im tarihi.17.01.2002.
  • Poole T. Happy animals make good science. Lab Anim, 1997; 31 (2): 116-24.
  • Laboratory Animals Science Association (LASA). Eri~im: hnp://www.lasa.co.uk Eri~im tarihi: 01.01.2002.
  • Hughes H C, Lang C M. Basic principles in selecting animal species for research projects. Clinical Toxicology, 1978: 13 (5): 611-621.
  • Davidson MK, Lindsey JR, Davis JK. Requirements and selection of an animal model. Isr J Med Sci, 1987; 23 (6): 551-5.
  • Selection of animal models. Eri~im: hnp://www.ahsc.arizona.edu/uac/notes/c1asses/anmodeIOl/animalmodelsOl.htmIEri~im tarihi: 1401.2002.
  • Krohn TC. Ritskes-Hoitinga J, Svendsen P. The effects of feeding and housing on the behaviour of the laboratory rabbit. Lab Anim. 1999: 33 (2): 101-7.
  • Otis E. Fang H. Species selection and animal models for toxicologic studies. Clinic Toxicolojy, 1978: 12 (2): 239-247.
  • Crouthamel WG. Abolin CR, Hsieh J, Lim JK. Intestinal pH as a factor in selection of animal models for bioavailability testing. J Pharm Sci. 1975: 64 (10): 1726-7.
  • Waynforth H B, Flecknell P.A. Experimental and Surgical Technique in The Rat. Second Edition. London: Academic Press, 1999: 337-367.
  • Canadian Council on Animal Care. Guidelines on: choosing an appropriate endpoint in experiments using animals or research. teaching and testing. Eri~im: hltp://www.ccac.ca/english/gdlines/endpts/appopen.htm Eri~im tarihi: 15.01.2002.
  • Close B. Banister K, Baumans V, Bernoth E-M, Bromage N, Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H. Morton 0, Warwick C. Recommendations for euthanasia of experimental animals: Part I. Laboratory Animals. 1996: 30: 293-316.
  • Ozkosc Z, Mentq B B, GargUl A, Deney Hayvanlannda Anestezi. Ankara: Barok Of set, 1998.
  • Close B. Banister K, Baumans V, Bernoth E-M, Bromage N. Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H, Morton D. Warwick C. Recommendations for euthanasia of experimental animals: Part 2. Laboratory Animals, 1997; 31: 1-32.
  • Hackbarth H, Kuppers N, Bohnet W. Euthanasia of rats with carbon dioxide-animal welfare aspects. Lab Anim, 2000: 34 (I): 91-6.
  • Hill R. Stanisstreet M, Boyes E. O'Sullivan H. Animal experimentation needs dissection. Nature, 1998; 391 (6663): 117.
  • Sharp P. Laregina M, Suckow MA. The Laboratory Rat (Laboratory Animal Pockct Reference Series, CRC Press, 1998.
  • Bahnemann R, Jacobs M, Karbe E, Kaufmann W, Morawiet.z G, Nolte T, Ritlinghausen S. Guides for organ sampling and trimming procedures in rats. 10urnal of Experimental and Toxicologic Pathology, 1995; 47: 247-266. Eri~im: hup://www.it.a.tllg.de/reni/trimming/index.htmIEri~im tarihi: 14.01.2002.
  • Rat dissection. Eri~im: http://umanitoba.ca/academic/faculties/science/biological_sciences/labI5/biolabI5_3.html#Histology Eri~im tarihi: 14.01.2002.
  • Rat anaesthesia and dissection. Eri~im: http://bioweb.wku/faculty/crawford/ratlab.hlm Eri~im tarihi: 10.01.2002.
  • Uzel i. Hayv
  • Obrink KJ, Rehbinder C. Animal definition: a necessity for the validity of animal experiments? Lab Anim, 2000; 34 (2): 121-30.
  • Smit.h JA, Birke L, Sadler D. Reponing animal use in scientific papers. Lab Anim, 1997 ;31 (4): 312-7.
  • Hilberg T. Ripel A, Siordal L, Bjorneboe A, Morland J. The extent. of postmortem drug redistribution in a rat model. 1 Forensic Sci. 1999; 44 (S): 956-62.
  • Elsirafy AA, Ghanem AA. Eid AE, Eldakroory SA. Chronological study of diazinon in putrefied viscera of rats using GC/MS, GC/EC and TLC. Forensic Sci Int, 2000; 109 (2): 147-57.
  • Hilberg T. Rogde S, Morland J. Postmortem drug redistribution--human cases related to results in experimental animals. J Forensic Sci. 1999: 44 (I): 3-9.
  • C;:oltu A. Suda bogulmada akciger patolojisi. II. Ulusal Adli TIp GUnleri . Bursa-TUrkiye, 25-28 Eyllil 1985: 125-131.
  • C;:oltu A, Oktan E. Kapalt onamlarda havaslz kalma sonucu geli~en iilUmicrde histopatolojik bulgular. III. Ulusal Adli TIp GUnlcri. istanbul-Tlirkiye. 6-8 Kasllll 1986: 223-234
  • Aksoy E. Termal ve Elektrik Aklllllanllln Meydana Getirdigi Lezyonlann AYJrlCI Tams!. Tlpt.a uzmanlIk tezi, Marmara Dniversitcsi, istanbul. 1996.

Yıl 2003, Cilt: 17 Sayı: 1, 82 - 92, 30.04.2003
https://izlik.org/JA87RF84NN

Öz

Kaynakça

  • Poyraz O. Laboratuvar Hayvanlan Bilimi. Ankara: Kardelen Of set, 2000: 3-81.
  • Some research alternatives to animal testing. Eri~im: http://www.bxscience.edu/-grollman/gallery/research.htmIEri~im tarihi.17.01.2002.
  • Poole T. Happy animals make good science. Lab Anim, 1997; 31 (2): 116-24.
  • Laboratory Animals Science Association (LASA). Eri~im: hnp://www.lasa.co.uk Eri~im tarihi: 01.01.2002.
  • Hughes H C, Lang C M. Basic principles in selecting animal species for research projects. Clinical Toxicology, 1978: 13 (5): 611-621.
  • Davidson MK, Lindsey JR, Davis JK. Requirements and selection of an animal model. Isr J Med Sci, 1987; 23 (6): 551-5.
  • Selection of animal models. Eri~im: hnp://www.ahsc.arizona.edu/uac/notes/c1asses/anmodeIOl/animalmodelsOl.htmIEri~im tarihi: 1401.2002.
  • Krohn TC. Ritskes-Hoitinga J, Svendsen P. The effects of feeding and housing on the behaviour of the laboratory rabbit. Lab Anim. 1999: 33 (2): 101-7.
  • Otis E. Fang H. Species selection and animal models for toxicologic studies. Clinic Toxicolojy, 1978: 12 (2): 239-247.
  • Crouthamel WG. Abolin CR, Hsieh J, Lim JK. Intestinal pH as a factor in selection of animal models for bioavailability testing. J Pharm Sci. 1975: 64 (10): 1726-7.
  • Waynforth H B, Flecknell P.A. Experimental and Surgical Technique in The Rat. Second Edition. London: Academic Press, 1999: 337-367.
  • Canadian Council on Animal Care. Guidelines on: choosing an appropriate endpoint in experiments using animals or research. teaching and testing. Eri~im: hltp://www.ccac.ca/english/gdlines/endpts/appopen.htm Eri~im tarihi: 15.01.2002.
  • Close B. Banister K, Baumans V, Bernoth E-M, Bromage N, Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H. Morton 0, Warwick C. Recommendations for euthanasia of experimental animals: Part I. Laboratory Animals. 1996: 30: 293-316.
  • Ozkosc Z, Mentq B B, GargUl A, Deney Hayvanlannda Anestezi. Ankara: Barok Of set, 1998.
  • Close B. Banister K, Baumans V, Bernoth E-M, Bromage N. Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H, Morton D. Warwick C. Recommendations for euthanasia of experimental animals: Part 2. Laboratory Animals, 1997; 31: 1-32.
  • Hackbarth H, Kuppers N, Bohnet W. Euthanasia of rats with carbon dioxide-animal welfare aspects. Lab Anim, 2000: 34 (I): 91-6.
  • Hill R. Stanisstreet M, Boyes E. O'Sullivan H. Animal experimentation needs dissection. Nature, 1998; 391 (6663): 117.
  • Sharp P. Laregina M, Suckow MA. The Laboratory Rat (Laboratory Animal Pockct Reference Series, CRC Press, 1998.
  • Bahnemann R, Jacobs M, Karbe E, Kaufmann W, Morawiet.z G, Nolte T, Ritlinghausen S. Guides for organ sampling and trimming procedures in rats. 10urnal of Experimental and Toxicologic Pathology, 1995; 47: 247-266. Eri~im: hup://www.it.a.tllg.de/reni/trimming/index.htmIEri~im tarihi: 14.01.2002.
  • Rat dissection. Eri~im: http://umanitoba.ca/academic/faculties/science/biological_sciences/labI5/biolabI5_3.html#Histology Eri~im tarihi: 14.01.2002.
  • Rat anaesthesia and dissection. Eri~im: http://bioweb.wku/faculty/crawford/ratlab.hlm Eri~im tarihi: 10.01.2002.
  • Uzel i. Hayv
  • Obrink KJ, Rehbinder C. Animal definition: a necessity for the validity of animal experiments? Lab Anim, 2000; 34 (2): 121-30.
  • Smit.h JA, Birke L, Sadler D. Reponing animal use in scientific papers. Lab Anim, 1997 ;31 (4): 312-7.
  • Hilberg T. Ripel A, Siordal L, Bjorneboe A, Morland J. The extent. of postmortem drug redistribution in a rat model. 1 Forensic Sci. 1999; 44 (S): 956-62.
  • Elsirafy AA, Ghanem AA. Eid AE, Eldakroory SA. Chronological study of diazinon in putrefied viscera of rats using GC/MS, GC/EC and TLC. Forensic Sci Int, 2000; 109 (2): 147-57.
  • Hilberg T. Rogde S, Morland J. Postmortem drug redistribution--human cases related to results in experimental animals. J Forensic Sci. 1999: 44 (I): 3-9.
  • C;:oltu A. Suda bogulmada akciger patolojisi. II. Ulusal Adli TIp GUnleri . Bursa-TUrkiye, 25-28 Eyllil 1985: 125-131.
  • C;:oltu A, Oktan E. Kapalt onamlarda havaslz kalma sonucu geli~en iilUmicrde histopatolojik bulgular. III. Ulusal Adli TIp GUnlcri. istanbul-Tlirkiye. 6-8 Kasllll 1986: 223-234
  • Aksoy E. Termal ve Elektrik Aklllllanllln Meydana Getirdigi Lezyonlann AYJrlCI Tams!. Tlpt.a uzmanlIk tezi, Marmara Dniversitcsi, istanbul. 1996.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Adli Biyoloji
Bölüm Araştırma Makalesi
Yazarlar

Ali Yemişcigil Bu kişi benim

Gönderilme Tarihi 1 Ocak 2003
Yayımlanma Tarihi 30 Nisan 2003
IZ https://izlik.org/JA87RF84NN
Yayımlandığı Sayı Yıl 2003 Cilt: 17 Sayı: 1

Kaynak Göster

Vancouver 1.Ali Yemişcigil. Laboratuvar Hayvanı Çalışmalarında İzlenecek Yol. ATD [Internet]. 01 Nisan 2003;17(1):82-9. Erişim adresi: https://izlik.org/JA87RF84NN

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