YENİDOĞANDA VİRAL PNÖMONİYE EŞLİK EDEN PELİOSİS HEPATİS: OLGU SUNUMU

Öz

Hastaneye ölü olarak getirildiği bildirilen ve ailesinden alınan öyküye göre de bir gün öncesine kadaryakınması bulunmayan 24 günlük erkek bebeğe yapılan otopsi sonucunda viral pnömoni ve peliosis hepatis teşhis edilmiştir. Bu yaş grubunda oldukça nadir görülmesi ve herhangi bir kronik tüketici hastalık ya da anabolizan ilaç kullanım öyküsü bulunmamasına rağmen viral pnömoni ile peliosis hepatis birlikteliği saptanmış olduğundan olguya ait veriler literatür örnekleriyle karşılaştırılarak sunulmuştur. Bebekte saptanan peliosis hepatis tablosunun, annenin kullanmış olabileceği ilaçlar kaynaklı olarak gelişebileceği de düşünülmüş, ancak aileye ulaşılamadığından bu konuda değerlendirme yapılamamıştır.

Anahtar Kelimeler

• Yenidoğan
• Viral pnömoni
• Peliosis hepatis

Kaynakça

1. Stocker JT, Louis PD, ed.Pediatric Pathology. Lippincott Williams&Wilkins,2002: 742.
2. Cotran RS, Kumar V, Robbins SL, ed. Robins Pathologic Basis of Disease. WB Saunders Co 1994: 873.
3. Ishak KG. Hepatic lesions caused by contraceptives and anabolic steroids. Semin liver Dis 1981; 1:116-18.
4. Kawamato S, Wakabayashi T. Peliosis hepatis in a newborn infant. Arch Pathol Lab Med 1980; 104:444-445.
5. Jacquemin E, et al. Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children. J.Hepatol. 1999; 30:1146-50.
6. Zafrani ES, et al. Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am.J.Pathol. 1984; 114:349-59.
7. Zafrani ES, Bernuau D, Feldmann G. Peliosis-like ultrastructural changes of the hepatic sinusoids in human chronic hypervitaminosis A: report of three cases. Hum.Pathol. 1984; 15:1166-70.
8. Degott C, et al. Peliosis hepatis in recipients of renal transplants. Gut 1978; 19:748-53.

9. Bagheri SA, Boyer JL. Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann.Intern.Med. 1974; 81:610-8.
10. Gelfand MM, Wiita B. Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941 to 1996. Clin.Ther. 1997; 19:383-404.
11. Pavlatos AM, et al. Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroid. Clin.Ther. 2001; 23:789-801.
12. Scoazec JY, et al. Peliosis hepatis and sinusoidal dilation during infection by the human immunodeficiency virus (HIV). An ultrastructural study. Am.J.Pathol. 1988; 131:38-47.
13. Cohen GS, et al. Peliosis hepatis mimicking hepatic abscess: fatal outcome following percutaneous drainage. J.Vasc.Interv.Radiol. 1994; 5:643-5.
14. Odièvre M, et al. Transitory hepatic peliosis in a child. Archives Francaises De Pediatrie 1977; 34:654-8.
15. Willen H, et al. Peliosis hepatis as a result of endogenous steroid hormone production. Virchows Arch.A Pathol.Anat.Histol. 1979; 383:233-40.
16. Nuernberger SP, Ramos CV. Peliosis hepatis in an infant. J.Pediatr. 1975; 87:424-6.
17. Marcus V.N. Corpa.et al. Peliosis hepatis associated with lymphoplasmocytic lymphoma: an autopsy case report. Archives of Pathology and Lab Med 2002; 128(11): 1283-1285.
18. Nadell J, Kosek J. Peliosis hepatis: twelve cases associated with oral androgen therapy. Arch Pathol Lab Med 1977; 101: 405-410.
19. Sherman D, Ramsay B, Theodorou NA.et al.Reversible plane xanthoma, vasculitis, and peliosis hepatis in giant lymph node hyperplasia (Castleman’s disease): a case report and review of the cutaneous manifestations of giant lymph node hyperplasia. J Am Acad Dermatol 1992; 26: 105-109.
20. Bhaskar KV, Joshi K, Banerjee CK.et al. Peliosis hepatis in Hodgkin’s disease: an infrequent association. Am J Gastroenterol 1990; 85: 628-629.
21. Simon DM, Krause R, Galambos JT. Peliosis hepatis in a patient with marasmus. Gastroenterology 1988; 95: 805-809.
22. Perochka LA, Geaghan SM, Yen TSB.et al. Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection. N Engl J Med 1990; 323: 1581-1586.
23. Zafrani ES, Degos F, Guigui B.et al. The hepatic sinusoid in hairy cell leukemia: an ultrastructural study of 12 cases. Hum Pathol 1987; 18: 801-807.
24. Fine KD, Solano M, Polter DE.et al. Malignant histiocytosis in a patient presenting with hepatic dysfunction and peliosis hepatis. Am J Gastroenterol 1995; 90: 485-488.
25. Izumi S, Nishiuchi M, Kameda Y.et al. Laparascopic study of peliosis hepatis and nodular transformation of the liver before and after renal transplantation: natural history and aetiology in follow-up cases. J Hepatol 1994; 20: 129-137.
26. Cavalcanti R, Pol S, Carnot F.et al. Impact and evollution of peliosis hepatis in renal transplant recipients. Transplantation 1994; 58: 315-316.
27. Sternberg SS,ed. Diagnostic Surgical Pathology. Lippincott Williams&Wilkins 1999:1514.
28. Van de Moortele K, Beele X, Hendrickx S.et al. Peliosis hepatis. The New England J Med 1997; 22: 1603.
29. Hiorns MP, Rossi UG, Roebuck DJ. Peliosis hepatis causing inferior vena cava compression in a 3-year-old child. Pediatr Radiol 2004; 22: 239-53
30. Shapiro P, Ikeda RM, Ruebner BH.et al. Multiple hepatic tumors and peliosis hepatis in Fanconi’s anemia treated with androgens. Am J Dis Child 1977; 131(10): 1104-6.
31. Omori H, Asahi H, Irinoda T.et al. Peliosis hepatis during postpartum period: successful embolisation of hepatic artery. J Gastroenterol 2004; 39(2): 168-71.
32. Ogo T, Monita C, Nomura H, Matsubara F, Naeyama S, Shirai-shi G. Tricuspid valve endocarditis in a non-drug addict associated with peliosis hepatis. Intern Med 1997; 36: 799-803.
33. Selby DM, Stocker JT. Focal peliosis hepatis, a sequela of asphyxial death? Pediatr Pathol Lab Med 1995; 15: 589-596.