The Morphological Features Of Immune System During Chronic Drug Addiction

Öz

The aim at the present study is to find out the features of the morphological changes of the immune system organs in different development stages of chronic drug addiction. For this study used the bodies of 53 individuals (45 men and 8 women) aged between 16 and 41, who were subjected to chronic drug addiction. Thirthy-five of them were forensic and 18 medical (people who die from various acute and chronic, relapsed infectious diseases) autopsy cases. The control group included the bodies of 15 men aged between 16 and 35, who died as a result of mechanical asphyxia. Studied histochemically and immunhistochemically metods on paraffin and selloidin sections. All observations were divided into two groups depending on the term of abusing narcotic substances: 1st group – chronic drug addicts using narcotics for 2 years; 2nd group – chronic drug addicts using narcotics from 2 to 10 years. The morphological changes in the immune system organs were mainly of reactive-hyper-plastic and dystrophic nature and were accompanied by acute micro-circulatory disturbances during the examinations in the 1st group. Necrotic, atrophic and sclerotic (both in parenchyma and interstition) changes along with the abovementioned pathological changes were discovered during the examinations in the 2nd group. This means the development of secondary B- and T-cell type immunodeficiency in patients.

Anahtar Kelimeler

• Chronic drug intoxication
• Immune system
• Secondary Immunodeficiency

Kaynakça

1. Colak B., Baser L., Yayci N., Etiler N., Inanici M.A. Deaths from drug overdose and toxicity in Turkey: 1997-2001. Amer. J. Forensic Med. Pathol. 2006; 27(1): 50-4.
2. Friedman H., Pross S., Klein T.W. Addictive drugs and their relationship with infectious diseases. FEMS Immunol. Med. Microbiol. 2006; 47(3): 330-42.
3. Krupitsky E.M., Zvortau E.E., Lioznov D.A. et al. Co-morbidity of infectious and addictive diseases in St.Peterburg and Leningrad Region, Rusia. Eur. Addict. Res. 2006; 12: 12-9.
4. Balster R.L. Introduction to special issue on substance abuse and the immune system. Drug and Alcohole Dependence. 2001; 62(2): 107.
5. Donahoe R.M., Adler M.W. Substance abuse and the immune system. Drug and Alcohol Dependence. 2001; 62(2): 109-10.
6. Eisenstein T.K., Rahim R.T., Feng P., Thingalaya N.K., Meissler J.J. Effects of opioid tolerance and withdrawal on the immune system. J.Neuroimmune Pharmacol 2006; 1-3: 237-49. Friedman H., Newton C., Klein T.W.
7. Zhao H., Ye T.H. Drug abuse and infection. Zhongguo. Microbial Infections, Immunomodulation and Drugs of Abuse. Clinical Microbiology Reviews. 2003; 16(2): 209-19.
8. Risberg VY. Characteristics of immune status and apoptozis at opium drug addiction. Avtoref. diss. can.med.sci. Russia. Ufa, 2002, 27 pp. 2006; 28(6): 858-61.

9. Sacerdote P. Opioid-indused immunosupression. Curr. Opin. Support Palliat Care. 2008; 2(1): 14-8.
10. Zaki N.G., Osman A., Moustafa H., Saad A.H. Alterations of immune functions in heroin addicts. Egypt J. Immunol. 2006; 13(1): 153-71.
11. Lunkova LK, Makarova OV, Kanibolotskiy AA, Mitkova SV. Morphology of immune system at drug addiction. Archive of Pathology. 2002; 4: 21-5.
12. Pigolkin YI, Bogomolov DV, Serstyuk BV. Forensic medical diagnostics of chronic drug addiction intoxication at morphological information. Sudebno-Medisinskaya Expertiza. 2000; (6): 41-5.
13. Salbacak A, Celik I, Karabulut AK, Ozkan Y, Uysal II, Ciceklibasi AE. Effects of morphine on the rat lymphoid organs and adrenal glands: Results of enzyme histochemical and histometric investigations. Rev. med. Vet. (France). 2001; 152 (10): 691-8.