Application of Botulinum Toxin in Oral and Maxillofacial Surgery

Yıl 2013, Cilt: 7 Sayı: 2, 1469 - 1478, 01.07.2013

Kübra Titirinli İsmail Doruk Koçyiğit M Ercüment Önder Fethi Atıl Umut Tekin

Öz

Injection of botulinum toxin, leads to temporary muscle paralysis by blocking the release of acetylcholine from the presynaptic neuron in neuromuscular junction. This is a dose-dependent reversible cosmetic and functional application. Botulinum toxin was used in the treatment of strabismus in 1980s for the first time. Application of botulinum toxin in dentistry has increased because of its minimal invasive nature with short operation time. In this article, the historical development of botulinum toxin, the structure and mechanism of action, market forms, dilution and storage conditions, toxicity, indications and contraindications, the possible development of resistance, uses in dentistry and oral maxillofacial surgery, and side effects are described with extensive literature review

Anahtar Kelimeler

Botulinum toxins, dentistry, injections, toxicity

Oral ve Maksillofasiyal Cerrahide Botulinum Toksin Uygulamaları

Öz

Botulinum toksin enjeksiyonu, nöromüsküler kavşakta presinaptik nöronlardan asetilkolin salınımını bloke ederek geçici kas paralizisine yol açan, etkisi doza bağımlı ve geri dönüşümlü kozmetik ve fonksiyonel bir uygulamadır. Botulinum toksin ilk kez 1980’li yıllarda strabismus tedavisinde kullanılmıştır. Minimal invaziv bir işlem oluşu ve operasyon süresinin kısa olması nedeniyle dişhekimliği alanında da botulinum toksin uygulamalarının kullanılabilirliği artmıştır. Bu derlemede, botulinum toksininin tarihsel gelişimi, yapısı ve etki mekanizması, ticari formları, dilüsyon ve saklama koşulları, toksisitesi, endikasyon ve kontrendikasyonları, olası direnç gelişimi, dişhekimliği ve oral maksillofasiyal cerrahide kullanım alanları ve olası yan etkileri geniş literatür desteği altında anlatılmıştır

Anahtar Kelimeler

Botulinum toksini, diş hekimliği, enjeksiyonlar, toksisite

Kaynakça

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• Journal of Clinical Sciences