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Clinical Evaluation of the Efficacy of Ethyl-2-Cyanoacrylate as a Bioadhesive Material in Periodontal Flap Surgery

Yıl 2012, Cilt: 6 Sayı: 1, 1082 - 1089, 01.04.2012

Öz

The purpose of this study was to compare the effects of ethyl-2-cyanoacrylate E-SA and conventional silk sutures on wound healing in periodontal flap surgery. 15 patients with chronic periodontitis with probing depth ≥5 mm in maxillar anterior region were included in the study. On the test site ethyl-2-cyanoacrylate was applied for flap closure after periodontal flap surgery n = 15 and on the control site silk sutures were used n = 15 . The plaque and gingival indices were recorded at baseline and 1 day, 3 days, 7 days, 14 days and 21 days after surgery. The following parameters were also recorded: pain, edema, erythema and necrosis. The cyanoacrylate was associated with less amount of inflammation during the healing period when compared with silk sutures p0.05 . Postoperative pain in cyanoacrylate group was less significant than in control group on the first and third day after surgery p

Kaynakça

  • Lee K. Cyanoacrylates in medicine. Can. Med. Assoc. J.127:359, 1982.
  • Blais P., Campbell RW. Cyanoacrylates in medi- cine. Can. Med. Assoc. J.126:227-229,1982.
  • Herod EL. Cyanoacrylates in dentistry: A revi- ew of literature. J. Can. Dent. Assoc. 56:331- 341,1990.
  • Grisdale J. The use of cyanoacrylates in perio- dontal therapy. J. Can. Dent. Assoc. 64: 632- 633,1998.
  • McGraw VA., Caffesse RG. Cyanoacrylates in periodontics. J. West. Soc. Periodontal. 26:4- 13,1978.
  • Miller GM., Dannenbaum R., Cohen WD. A pre- liminary histologic study of the wound healing of mucogingival flaps when secured with cyanoacr- ylate tissue adhesives. J. Periodontol. 45:608- 618,1974.
  • Joshi AD., Saluja H., Mahindra U., Halli R. A com- parative study: efficacy of tissue glue and sutures after impacted mandibular third molar removal. J. Maxillofac. Oral Surg. 10:310-315,2011.
  • Choi B-H., Kim B-Y., Huh J-Y., Lee S-H., Zhu S-J., Jung J-H., Li J. Cyanoacrylate adhesive for closing sinus membrane perforations during sinus lifts. J. Cranio-Maxillofac. Surg. 34:505–509,2006.
  • Barbosa FI., Corrêa DS., Zenóbio EG., Costa FO., Shibli JA. Dimensional changes between free gingival grafts fixed with ethyl cyanoacr- ylate and silk sutures. J. Int. Acad. Periodontol. 11:170-176,2009.
  • Arici N., Sener I., Bereket C., Arici S. Orto- dontik ataçmanların yapıştırılmasında bir doku yapıştırıcısının kullanılması: bir laboratuar çalış- ma. Atatürk Üniv. Diş Hek. Fak. Derg. 21:213- 218,2011.
  • Manfrin TM., Poi WR., de Mendonça MR., Car- doso LC., Massa Sundefeld ML., Sonoda CK., Panzarini SR. Analysis in vitro of direct bonding system with cyanoacrylate ester and orthodontic wires. Dent. Traumatol. 25:229-232,2009.
  • Pérez Mde L., Mayelin Guerra R., Fernández M., Márquez D., Velazco G., Rodríguez J., Alemán E., Garcia L., Suárez O., Rodríguez Mdel C., Sañudo J. Effectiveness and safety of tisuacryl in treating dentin hypersensitivity (DH). MEDICC. Rev Winter;12:24-28,2010.
  • Cueto EI., Buonocore MG. Sealing of pits and fissures with an adhesive resin: Its use in caries prevention. J. Am. Dent. Assoc. 75: 121,1967.
  • Berkman MD., Cucolo FA., Levin MP., Brunel- le LJ. Pulpal response to isobutyl cyanoacrylate in human teeth. J. Am. Dent. Assoc. 83:140- 145,1971.
  • Torabinejad M., Kahn H., Bankes D. Isopropyl cyanoacrylate as a root canal sealer. J. Endod. 10:304-307,1984.
  • Barkhordar RA., Javid B., Abbasi J., Watana- be LG. Cyanoacrylate as a retrofillingmaterial. Oral Surg. Oral Med. Oral Pathol. 65:468- 473,1988.
  • Lahiffe BJ., Caffesse RG., Nasjleti CE. Healing of periodontal flaps following use of MBR 4197 (flucrylate) in rhesus monkeys. A clinical and histological evaluation. J. Periodontol. 49:635- 645,1978.
  • McGraw VA., Caffesse RG., Nasjleti CE. Healing of periodontal flaps following use of MBR 4197 (flucrylate) in rhesus monkeys. A biometric and histometric evaluation. J. Periodontol. 50:305- 310,1979.
  • Binnie WH., Forrest JO. A study of tissue respon- se to cyanoacrylate adhesive in periodontal sur- gery. J. Periodontol. 45:619-625,1974.
  • Kulkarni S., Dodwad V., Chava V. Healing of pe- riodontal flaps when closed with silk sutures and N-butyl cyanoacrylate: a clinical and histological study. Indian J. Dent. Res. 18:72-77,2007.
  • Farnoush A. Techniques for the protection and co- verage of the donor sites in free soft tissue grafts. J. Periodontol. 49:403-405,1978.
  • Dogon IL., Heeley JD. A study on the use of fluo- roalkyl cyanoacrylate adhesive as a hemostatic agent and dressing after exodontia. Oral Surg. Oral Med. Oral Pathol. 45:503-515,1978.
  • Padhye A., Pol DG. Clinical Evaluation of the Ef- ficacy of N-butyl 2-Cyanoacrylate as a Bioadhe- sive Material in Comparison to Conventional Silk Sutures in Modified Widman Flap Surgery in the Anterior Region. JIDA. 5: 899-904,2011.
  • Quigley GA., Hein JW. Comparative cleansing efficiency of manual and power brushing. J. Am. Dent. Assoc. 65:26-29,1962.
  • Loe H., Silness J. Periodontal Disease in Preg- nancy. I. Prevalence and Severity. Acta Odontol. Scand. 21:533-551,1963.
  • Melzack R. The McGill Pain Questionnaire: ma- jor properties and scoring methods. Pain. 1:277- 299,1975.
  • Selvig KA., Biagiotti GR., Leknes KN., Wikesjö UME. Oral tissue reactions to suture materials. IJPRD. 18: 475-487,1998.
  • Wallace WR., Maxwell GR., Cavalaris CJ. Com- parison of polyglycolic acid suture to black silk, chromic and plain catgut in human oral tissues. Oral Surg. Oral Med. Oral Pathol. 28:739- 746,1970.
  • Okamoto T., Gabrielli MF., Gabrielli MA. Influ- ence of different types of non-resorbable suture material on the healing of extraction wounds--a histological study in rats. J. Nihon Univ. Sch. Dent. 32:104-115,1990.
  • Lilly GE., Osbon DB., Hutchinson RA., Heflich RH. Clinical and bacteriological aspects of polyglicolic acid sutures. J. Oral Surg. 31:103-105,1973.
  • Racey GL., Wallace WR., Cavalaris CJ., Margu- ard JV. Comparison of a polyglicolic-polylactic acid suture to black silk and plain catgut in hu- man oral tissues. Oral Surg. Oral Med. Oral Pat- hol. 36:766-770,1978.
  • Parirokh M., Asgary M., Eghbal MJ., Stowe S., Kakoei S. A scanning electron microscope study of plaque accumulation on silk and PVDF suture materials in oral mucosa. Int. Endod. J. 37:776- 781,2004.
  • Müller RH., Lherm C., Herbort J., Couvreur P. In vitro model for the degradation of alkylcyanoacr- ylate nanoparticles. Biomaterials 11:590,1990.
  • Lenaerts V., Couvreur P., Christiaens-Leyh D., Jo- iris E., Roland M., Rollman B., Speiser P. Degra- dation of poly (isobutyl cyanoacrylate) nanopar- ticles. Biomaterials 5:65,1984.
  • De Melo WM., Maximiano WM., Antunes AA., Beloti MM., Rosa AL., de Oliveira PT. Cytotoxicity testing of methyl and ethyl 2-cyanoacrylate using direct contact assay on osteoblast cell cultures. J. Oral Maxillofac. Surg. 71:35-41,2013.
  • Kulkarni S., Dodwad V., Chava V. Healing of pe- riodontal flaps when closed with silk sutures and N-butyl cyanoacrylate: a clinical and histological study. Indian J. Dent. Res. 18:72-77,2007.
  • Giray CB., Atasever A., Durgun B., Araz K. Cli- nical and electron microscope comparison of silk sutures and N-butyl-2-cyanoacrylate in human mucosa. Aust. Dent. J. 42:255-258,1997.
  • Ghoreishian M., Gheisari R., Fayazi M. Tissue adhesive and suturing for closure of the surgical wound after removal of impacted mandibular third molars: a comparative study. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108:14-16,2009.

Periodontal Flep Cerrahisinde Bioadeziv Bir Materyal Olan Etil-2-Siyanoakrilat’ın Klinik Etkinliğinin Değerlendirilmesi

Yıl 2012, Cilt: 6 Sayı: 1, 1082 - 1089, 01.04.2012

Öz

Bu çalışmanın amacı, etil-2-siyanoakrilat ve konvansiyonel ipek süturlerin periodontal flep cerrahisinde kullanımlarının yara iyileşmesi üzerine etkilerini incelemektir. Faz I periodontal tedavi sonrası, maksiller anterior bölgelerinde 5mm ve üzeri sondlanabilen cep derinliği olan, 15 kronik periodontitis hastası çalışmaya dâhil edildi. Test bölgelerinde flepler etil2-siyanoakrilat E-SA ile kapatılırken n = 15 , kontrol bölgelerinde 3/0 ipek süturler kullanıldı n = 15 . Plak indeksi ve gingival indeks başlangıçta ve operasyonu takiben 1., 3., 7., 14. ve 21. günlerde kaydedildi. Ayrıca ağrı, ödem, eritem ve nekroz skorları da değerlendirildi. Çalışma boyunca siyanoakrilat uygulanan grupta ipek süturlara kıyasla daha az inflamasyon gözlendi p0.05 . Siyanoakrilat grubunda 1. ve 3. günlerde istatistiksel olarak anlamlı daha az postoperatif ağrı bulgulandı p

Kaynakça

  • Lee K. Cyanoacrylates in medicine. Can. Med. Assoc. J.127:359, 1982.
  • Blais P., Campbell RW. Cyanoacrylates in medi- cine. Can. Med. Assoc. J.126:227-229,1982.
  • Herod EL. Cyanoacrylates in dentistry: A revi- ew of literature. J. Can. Dent. Assoc. 56:331- 341,1990.
  • Grisdale J. The use of cyanoacrylates in perio- dontal therapy. J. Can. Dent. Assoc. 64: 632- 633,1998.
  • McGraw VA., Caffesse RG. Cyanoacrylates in periodontics. J. West. Soc. Periodontal. 26:4- 13,1978.
  • Miller GM., Dannenbaum R., Cohen WD. A pre- liminary histologic study of the wound healing of mucogingival flaps when secured with cyanoacr- ylate tissue adhesives. J. Periodontol. 45:608- 618,1974.
  • Joshi AD., Saluja H., Mahindra U., Halli R. A com- parative study: efficacy of tissue glue and sutures after impacted mandibular third molar removal. J. Maxillofac. Oral Surg. 10:310-315,2011.
  • Choi B-H., Kim B-Y., Huh J-Y., Lee S-H., Zhu S-J., Jung J-H., Li J. Cyanoacrylate adhesive for closing sinus membrane perforations during sinus lifts. J. Cranio-Maxillofac. Surg. 34:505–509,2006.
  • Barbosa FI., Corrêa DS., Zenóbio EG., Costa FO., Shibli JA. Dimensional changes between free gingival grafts fixed with ethyl cyanoacr- ylate and silk sutures. J. Int. Acad. Periodontol. 11:170-176,2009.
  • Arici N., Sener I., Bereket C., Arici S. Orto- dontik ataçmanların yapıştırılmasında bir doku yapıştırıcısının kullanılması: bir laboratuar çalış- ma. Atatürk Üniv. Diş Hek. Fak. Derg. 21:213- 218,2011.
  • Manfrin TM., Poi WR., de Mendonça MR., Car- doso LC., Massa Sundefeld ML., Sonoda CK., Panzarini SR. Analysis in vitro of direct bonding system with cyanoacrylate ester and orthodontic wires. Dent. Traumatol. 25:229-232,2009.
  • Pérez Mde L., Mayelin Guerra R., Fernández M., Márquez D., Velazco G., Rodríguez J., Alemán E., Garcia L., Suárez O., Rodríguez Mdel C., Sañudo J. Effectiveness and safety of tisuacryl in treating dentin hypersensitivity (DH). MEDICC. Rev Winter;12:24-28,2010.
  • Cueto EI., Buonocore MG. Sealing of pits and fissures with an adhesive resin: Its use in caries prevention. J. Am. Dent. Assoc. 75: 121,1967.
  • Berkman MD., Cucolo FA., Levin MP., Brunel- le LJ. Pulpal response to isobutyl cyanoacrylate in human teeth. J. Am. Dent. Assoc. 83:140- 145,1971.
  • Torabinejad M., Kahn H., Bankes D. Isopropyl cyanoacrylate as a root canal sealer. J. Endod. 10:304-307,1984.
  • Barkhordar RA., Javid B., Abbasi J., Watana- be LG. Cyanoacrylate as a retrofillingmaterial. Oral Surg. Oral Med. Oral Pathol. 65:468- 473,1988.
  • Lahiffe BJ., Caffesse RG., Nasjleti CE. Healing of periodontal flaps following use of MBR 4197 (flucrylate) in rhesus monkeys. A clinical and histological evaluation. J. Periodontol. 49:635- 645,1978.
  • McGraw VA., Caffesse RG., Nasjleti CE. Healing of periodontal flaps following use of MBR 4197 (flucrylate) in rhesus monkeys. A biometric and histometric evaluation. J. Periodontol. 50:305- 310,1979.
  • Binnie WH., Forrest JO. A study of tissue respon- se to cyanoacrylate adhesive in periodontal sur- gery. J. Periodontol. 45:619-625,1974.
  • Kulkarni S., Dodwad V., Chava V. Healing of pe- riodontal flaps when closed with silk sutures and N-butyl cyanoacrylate: a clinical and histological study. Indian J. Dent. Res. 18:72-77,2007.
  • Farnoush A. Techniques for the protection and co- verage of the donor sites in free soft tissue grafts. J. Periodontol. 49:403-405,1978.
  • Dogon IL., Heeley JD. A study on the use of fluo- roalkyl cyanoacrylate adhesive as a hemostatic agent and dressing after exodontia. Oral Surg. Oral Med. Oral Pathol. 45:503-515,1978.
  • Padhye A., Pol DG. Clinical Evaluation of the Ef- ficacy of N-butyl 2-Cyanoacrylate as a Bioadhe- sive Material in Comparison to Conventional Silk Sutures in Modified Widman Flap Surgery in the Anterior Region. JIDA. 5: 899-904,2011.
  • Quigley GA., Hein JW. Comparative cleansing efficiency of manual and power brushing. J. Am. Dent. Assoc. 65:26-29,1962.
  • Loe H., Silness J. Periodontal Disease in Preg- nancy. I. Prevalence and Severity. Acta Odontol. Scand. 21:533-551,1963.
  • Melzack R. The McGill Pain Questionnaire: ma- jor properties and scoring methods. Pain. 1:277- 299,1975.
  • Selvig KA., Biagiotti GR., Leknes KN., Wikesjö UME. Oral tissue reactions to suture materials. IJPRD. 18: 475-487,1998.
  • Wallace WR., Maxwell GR., Cavalaris CJ. Com- parison of polyglycolic acid suture to black silk, chromic and plain catgut in human oral tissues. Oral Surg. Oral Med. Oral Pathol. 28:739- 746,1970.
  • Okamoto T., Gabrielli MF., Gabrielli MA. Influ- ence of different types of non-resorbable suture material on the healing of extraction wounds--a histological study in rats. J. Nihon Univ. Sch. Dent. 32:104-115,1990.
  • Lilly GE., Osbon DB., Hutchinson RA., Heflich RH. Clinical and bacteriological aspects of polyglicolic acid sutures. J. Oral Surg. 31:103-105,1973.
  • Racey GL., Wallace WR., Cavalaris CJ., Margu- ard JV. Comparison of a polyglicolic-polylactic acid suture to black silk and plain catgut in hu- man oral tissues. Oral Surg. Oral Med. Oral Pat- hol. 36:766-770,1978.
  • Parirokh M., Asgary M., Eghbal MJ., Stowe S., Kakoei S. A scanning electron microscope study of plaque accumulation on silk and PVDF suture materials in oral mucosa. Int. Endod. J. 37:776- 781,2004.
  • Müller RH., Lherm C., Herbort J., Couvreur P. In vitro model for the degradation of alkylcyanoacr- ylate nanoparticles. Biomaterials 11:590,1990.
  • Lenaerts V., Couvreur P., Christiaens-Leyh D., Jo- iris E., Roland M., Rollman B., Speiser P. Degra- dation of poly (isobutyl cyanoacrylate) nanopar- ticles. Biomaterials 5:65,1984.
  • De Melo WM., Maximiano WM., Antunes AA., Beloti MM., Rosa AL., de Oliveira PT. Cytotoxicity testing of methyl and ethyl 2-cyanoacrylate using direct contact assay on osteoblast cell cultures. J. Oral Maxillofac. Surg. 71:35-41,2013.
  • Kulkarni S., Dodwad V., Chava V. Healing of pe- riodontal flaps when closed with silk sutures and N-butyl cyanoacrylate: a clinical and histological study. Indian J. Dent. Res. 18:72-77,2007.
  • Giray CB., Atasever A., Durgun B., Araz K. Cli- nical and electron microscope comparison of silk sutures and N-butyl-2-cyanoacrylate in human mucosa. Aust. Dent. J. 42:255-258,1997.
  • Ghoreishian M., Gheisari R., Fayazi M. Tissue adhesive and suturing for closure of the surgical wound after removal of impacted mandibular third molars: a comparative study. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108:14-16,2009.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Burcu Karaduman Bu kişi benim

Ahu Uraz Bu kişi benim

Süleyman Bozkaya Bu kişi benim

Cem Yıldız Bu kişi benim

Kaya Eren Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 6 Sayı: 1

Kaynak Göster

Vancouver Karaduman B, Uraz A, Bozkaya S, Yıldız C, Eren K. Periodontal Flep Cerrahisinde Bioadeziv Bir Materyal Olan Etil-2-Siyanoakrilat’ın Klinik Etkinliğinin Değerlendirilmesi. ADO Klinik Bilimler Dergisi. 2012;6(1):1082-9.