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Significance of Dental Stem Cells in Dentistry and Stem Cell Banking

Yıl 2024, Cilt: 13 Sayı: 2, 402 - 408, 20.05.2024
https://doi.org/10.54617/adoklinikbilimler.1431309

Öz

Dentists play a crucial role in collecting stem cells for dental treatments and the potential treatment of medical diseases. Considering dental stem cells (DSCs) in terms of their increasing potential in medicine, adequate knowledge and positive attitudes of dentists toward DSCs and their use in regenerative therapies are extremely important. The immense potential of DSCs in regenerative medicine applications for various treatments suggests their significant role in both dental treatments and innovative approaches to treating various diseases. “Dental banking” emerged as a result of DSCs’ use in medical applications and their numerous clinical advantages across regenerative medical domains. DSC banking is a service that makes it possible to store and utilize DSCs for potential medical applications. However, further clinical research is needed to advance the applications of DSCs in treatment. This review aims to summarize the current literature on dental stem cell banking applications and usage areas of DSCs in dentistry.

Kaynakça

  • Casagrande L, Grando Mattuella L, Borba de Araujo F, Eduardo J. Stem cells in dental practice: perspectives in conservative pulp therapies. J Clin Pediatr Dent 2007;31:25-7.
  • Zhang H, Wang ZZ. Mechanisms that mediate stem cell self‐renewal and differentiation. J Cell Biochem 2008;103:709-18.
  • Delilbaşı L. İn vitro fertilizasyon (IVF) laboratuvar yöntemleri. In: Delilbaşı L (eds) Ankara: Öncü Basımevi 2008:1-31.
  • Rai S, Kaur M, Kaur S. Applications of stem cells in interdisciplinary dentistry and beyond: an overview. Ann Med Health Sci Res 2013;3:245.
  • Coulombel L. Adult tissue stem cells: definition, identification and therapeutic use. Journ Annu Diabetol Hotel Dieu 2003:1-16.
  • Ferrari G, Cusella– G, Angelis D, Coletta M, Paolucci E, Stornaiuolo A, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279:1528-0.
  • Majeski J. Dental stem cells in research and practice. Access 2009;26:24-6.
  • Glick M. Stem cell research and oral health. J Am Dent Assoc 2009;140:514.
  • Suzergoz F, Erdem A, Sepet E, Bektas M, Yalman N, Gurol A. A pilot study on the isolation of dental pulp stem cells, potential of forming colonies and defining the content of stem cells. Turkiye Klinikleri J Med Sci 2009;29.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-30.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003;100:5807-12.
  • Han J, Okada H, Takai H, Nakayama Y, Maeda T, Ogata Y. Collection and culture of alveolar bone marrow multipotent mesenchymal stromal cells from older individuals. J Cell Biochem 2009;107:1198-204.
  • Guo J, Weng J, Rong Q, Zhang X, Zhu S, Huang D, et al. Investigation of multipotent postnatal stem cells from human maxillary sinus membrane. Sci Rep. 2015;5:11660.
  • Karaöz E, Demircan PC, Sağlam Ö, Aksoy A, Kaymaz F, Duruksu G. Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells. Histochem Cell Biol 2011;136:455-73.
  • Sharpe PT. Dental mesenchymal stem cells. Development 2016;143:2273-80.
  • Lin NH, Gronthos S, Bartold P. Stem cells, tissue engineering and periodontal regeneration. Aus Dent J 2008;53:108-21.
  • Hasegawa M, Yamato M, Kikuchi A, Okano T, Ishikawa I. Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an athymic rat model. Tissue Eng 2005;11:469-78.
  • Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol 2010;20:715-22.
  • Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • Tziafas D. The future role of a molecular approach to pulp-dentinal regeneration. Caries Res 2004;38:314-20.
  • Miyagi SPH, Kerkis I, da Costa Maranduba CM, Gomes CM, Martins MD, Marques MM. Expression of extracellular matrix proteins in human dental pulp stem cells depends on the donor tooth conditions. J Endod 2010;36:826-31.
  • Morsczeck C, Frerich B, Driemel O. Dental stem cell patents. Recent Patents on DNA & Gene Sequences. Recent Pat DNA Gene Seq 2009;3:39-43.
  • Huang GT-J, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, et al. Stem/progenitor cell–mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 2010;16:605-15.
  • Duailibi M, Duailibi S, Young C, Bartlett J, Vacanti J, Yelick P. Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 2004;83:523-8.
  • Gronthos S, Simmons PJ. The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 1995.
  • Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, et al. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci U S A 2009;106:13475-80.
  • Hall PA, Watt FM. Stem cells: the generation and maintenance of cellular diversity. Development 1989;106:619-33.
  • Lee S-M, Zhang Q, Le AD. Dental stem cells: sources and potential applications. Current Oral Health Reports 2014;1:34-42.
  • Liu J, Yu F, Sun Y, Jiang B, Zhang W, Yang J, et al. Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem cells 2015;33:627-38.
  • Yamada Y, Nakamura-Yamada S, Kusano K, Baba S. Clinical potential and current progress of dental pulp stem cells for various systemic diseases in regenerative medicine: a concise review. Int J Mol Sci 2019;20:1132.
  • Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engineering and regenerative medicine. Ann Med 2017;49:644-51.
  • Dickinson BP, Ashley RK, Wasson KL, O’Hara C, Gabbay J, Heller JB, et al. Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects. Plastic Recontr Surg 2008;121:209-17.
  • Alonso N, Tanikawa DYS, Freitas RdS, Canan Jr L, Ozawa TO, Rocha DL. Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients. Tissue Eng Part C Methods 2010;16:1183-9.
  • Pradel W, Eckelt U, Lauer G. Bone regeneration after enucleation of mandibular cysts: comparing autogenous grafts from tissue-engineered bone and iliac bone. Oral Surgery, Oral Medicine, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:285-90.
  • Tanikawa D, Pinheiro CC, Almeida MCA, Oliveira CR, Coudry RdA, Rocha DL, et al. Deciduous dental pulp stem cells for maxillary alveolar reconstruction in cleft lip and palate patients. Stem Cells Int 2020;2020:6234167.
  • d’Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
  • Werle SB, Lindemann D, Steffens D, Demarco FF, de Araujo FB, Pranke P, et al. Carious deciduous teeth are a potential source for dental pulp stem cells. Clin Oral Investig 2016;20:75-81.
  • Tsai AI, Hong H-H, Lin W-R, Fu J-F, Chang C-C, Wang I, et al. Isolation of mesenchymal stem cells from human deciduous teeth pulp Biomed Res Int. 2017;2017.
  • Pereira L, Rubini M, Silva J, Oliveira D, Silva I, Poças‐Fonseca M, et al. Comparison of stem cell properties of cells isolated from normal and inflamed dental pulps. Int Endod J 2012;45:1080-90.
  • Malekfar A, Valli KS, Kanafi MM, Bhonde RR. Isolation and characterization of human dental pulp stem cells from cryopreserved pulp tissues obtained from teeth with irreversible pulpitis. J Endod 2016;42:76-81.
  • Yamada Y, Nakamura-Yamada S, Konoki R, Baba S. Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine. Stem Cell Res Ther 2020;11:1-10.
  • Sivolella S, Scanu A, Xie Z, Vianello S, Stellini E. Biobanking in dentistry: A review. Jpn Dent Sci Rev 2022;58:31-40.
  • Eklund N, Andrianarisoa NH, van Enckevort E, Anton G, Debucquoy A, Müller H, et al. Extending the minimum information about biobank data sharing terminology to describe samples, sample donors, and events. Biopreserv Biobank 2020;18:155-64.
  • Kahraman Ş, Delilbaşı E. Uses of stem cells in dentistry and awareness of dental stem cells. ADO Klinik Bilimler Dergisi 2022;11:65-70.

Diş Hekimliğinde ve Kök Hücre Bankacılığında Dental Kök Hücrelerinin Önemi

Yıl 2024, Cilt: 13 Sayı: 2, 402 - 408, 20.05.2024
https://doi.org/10.54617/adoklinikbilimler.1431309

Öz

Diş hekimleri, yalnızca dental tedaviler için değil, aynı zamanda tıbbi hastalıkların potansiyel tedavisi için kök hücre toplamada önemli bir rol oynayabilir. Tıp alanında dental kök hücrelerin giderek artan potansiyeli göz önüne alındığında, diş hekimlerinin dental kök hücreler ve rejeneratif tedavilerde kullanımına yönelik yeterli bilgi ve olumlu tutumları son derece önemlidir. Dental kök hücrelerin çeşitli tedaviler için rejeneratif tıp uygulamalarında büyük bir potansiyele sahip olması, gelecekte yalnızca dental tedavilerde değil, çeşitli hastalıkların tedavisinde yenilikçi yaklaşımlarda önemli bir rol oynayabileceğini düşündürmektedir. Dental kök hücreler çeşitli klinik faydaları olduğundan ve rejeneratif tıbbın çeşitli alanlarında uygulandığından, dental kök hücrelerin tıbbi uygulamalar için korunması “diş bankası” kavramını oluşturmuştur. Dental kök hücre bankacılığı, dental kök hücrelerin saklanması ve gelecekte tıbbi tedaviler için kullanılabilmesini sağlayan bir hizmettir. Bununla birlikte, dental kök hücrelerin gelecekteki kullanım alanları ve bu hücrelerin potansiyel tedavi yöntemlerinin geliştirilebilmesi için çalışmaların devam etmesi ve klinik araştırmaların yapılması gerekmektedir. Bu derlemenin amacı diş hekimliğinde dental kök hücre bankacılığı uygulamalarına ve dental kök hücrelerin kullanım alanlarına dair mevcut literatürü özetlemektir.

Kaynakça

  • Casagrande L, Grando Mattuella L, Borba de Araujo F, Eduardo J. Stem cells in dental practice: perspectives in conservative pulp therapies. J Clin Pediatr Dent 2007;31:25-7.
  • Zhang H, Wang ZZ. Mechanisms that mediate stem cell self‐renewal and differentiation. J Cell Biochem 2008;103:709-18.
  • Delilbaşı L. İn vitro fertilizasyon (IVF) laboratuvar yöntemleri. In: Delilbaşı L (eds) Ankara: Öncü Basımevi 2008:1-31.
  • Rai S, Kaur M, Kaur S. Applications of stem cells in interdisciplinary dentistry and beyond: an overview. Ann Med Health Sci Res 2013;3:245.
  • Coulombel L. Adult tissue stem cells: definition, identification and therapeutic use. Journ Annu Diabetol Hotel Dieu 2003:1-16.
  • Ferrari G, Cusella– G, Angelis D, Coletta M, Paolucci E, Stornaiuolo A, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279:1528-0.
  • Majeski J. Dental stem cells in research and practice. Access 2009;26:24-6.
  • Glick M. Stem cell research and oral health. J Am Dent Assoc 2009;140:514.
  • Suzergoz F, Erdem A, Sepet E, Bektas M, Yalman N, Gurol A. A pilot study on the isolation of dental pulp stem cells, potential of forming colonies and defining the content of stem cells. Turkiye Klinikleri J Med Sci 2009;29.
  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-30.
  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 2003;100:5807-12.
  • Han J, Okada H, Takai H, Nakayama Y, Maeda T, Ogata Y. Collection and culture of alveolar bone marrow multipotent mesenchymal stromal cells from older individuals. J Cell Biochem 2009;107:1198-204.
  • Guo J, Weng J, Rong Q, Zhang X, Zhu S, Huang D, et al. Investigation of multipotent postnatal stem cells from human maxillary sinus membrane. Sci Rep. 2015;5:11660.
  • Karaöz E, Demircan PC, Sağlam Ö, Aksoy A, Kaymaz F, Duruksu G. Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells. Histochem Cell Biol 2011;136:455-73.
  • Sharpe PT. Dental mesenchymal stem cells. Development 2016;143:2273-80.
  • Lin NH, Gronthos S, Bartold P. Stem cells, tissue engineering and periodontal regeneration. Aus Dent J 2008;53:108-21.
  • Hasegawa M, Yamato M, Kikuchi A, Okano T, Ishikawa I. Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an athymic rat model. Tissue Eng 2005;11:469-78.
  • Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol 2010;20:715-22.
  • Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-55.
  • Tziafas D. The future role of a molecular approach to pulp-dentinal regeneration. Caries Res 2004;38:314-20.
  • Miyagi SPH, Kerkis I, da Costa Maranduba CM, Gomes CM, Martins MD, Marques MM. Expression of extracellular matrix proteins in human dental pulp stem cells depends on the donor tooth conditions. J Endod 2010;36:826-31.
  • Morsczeck C, Frerich B, Driemel O. Dental stem cell patents. Recent Patents on DNA & Gene Sequences. Recent Pat DNA Gene Seq 2009;3:39-43.
  • Huang GT-J, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, et al. Stem/progenitor cell–mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 2010;16:605-15.
  • Duailibi M, Duailibi S, Young C, Bartlett J, Vacanti J, Yelick P. Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 2004;83:523-8.
  • Gronthos S, Simmons PJ. The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-deprived conditions in vitro. Blood 1995.
  • Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, et al. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci U S A 2009;106:13475-80.
  • Hall PA, Watt FM. Stem cells: the generation and maintenance of cellular diversity. Development 1989;106:619-33.
  • Lee S-M, Zhang Q, Le AD. Dental stem cells: sources and potential applications. Current Oral Health Reports 2014;1:34-42.
  • Liu J, Yu F, Sun Y, Jiang B, Zhang W, Yang J, et al. Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem cells 2015;33:627-38.
  • Yamada Y, Nakamura-Yamada S, Kusano K, Baba S. Clinical potential and current progress of dental pulp stem cells for various systemic diseases in regenerative medicine: a concise review. Int J Mol Sci 2019;20:1132.
  • Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engineering and regenerative medicine. Ann Med 2017;49:644-51.
  • Dickinson BP, Ashley RK, Wasson KL, O’Hara C, Gabbay J, Heller JB, et al. Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects. Plastic Recontr Surg 2008;121:209-17.
  • Alonso N, Tanikawa DYS, Freitas RdS, Canan Jr L, Ozawa TO, Rocha DL. Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients. Tissue Eng Part C Methods 2010;16:1183-9.
  • Pradel W, Eckelt U, Lauer G. Bone regeneration after enucleation of mandibular cysts: comparing autogenous grafts from tissue-engineered bone and iliac bone. Oral Surgery, Oral Medicine, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:285-90.
  • Tanikawa D, Pinheiro CC, Almeida MCA, Oliveira CR, Coudry RdA, Rocha DL, et al. Deciduous dental pulp stem cells for maxillary alveolar reconstruction in cleft lip and palate patients. Stem Cells Int 2020;2020:6234167.
  • d’Aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
  • Werle SB, Lindemann D, Steffens D, Demarco FF, de Araujo FB, Pranke P, et al. Carious deciduous teeth are a potential source for dental pulp stem cells. Clin Oral Investig 2016;20:75-81.
  • Tsai AI, Hong H-H, Lin W-R, Fu J-F, Chang C-C, Wang I, et al. Isolation of mesenchymal stem cells from human deciduous teeth pulp Biomed Res Int. 2017;2017.
  • Pereira L, Rubini M, Silva J, Oliveira D, Silva I, Poças‐Fonseca M, et al. Comparison of stem cell properties of cells isolated from normal and inflamed dental pulps. Int Endod J 2012;45:1080-90.
  • Malekfar A, Valli KS, Kanafi MM, Bhonde RR. Isolation and characterization of human dental pulp stem cells from cryopreserved pulp tissues obtained from teeth with irreversible pulpitis. J Endod 2016;42:76-81.
  • Yamada Y, Nakamura-Yamada S, Konoki R, Baba S. Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine. Stem Cell Res Ther 2020;11:1-10.
  • Sivolella S, Scanu A, Xie Z, Vianello S, Stellini E. Biobanking in dentistry: A review. Jpn Dent Sci Rev 2022;58:31-40.
  • Eklund N, Andrianarisoa NH, van Enckevort E, Anton G, Debucquoy A, Müller H, et al. Extending the minimum information about biobank data sharing terminology to describe samples, sample donors, and events. Biopreserv Biobank 2020;18:155-64.
  • Kahraman Ş, Delilbaşı E. Uses of stem cells in dentistry and awareness of dental stem cells. ADO Klinik Bilimler Dergisi 2022;11:65-70.
Toplam 44 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ağız ve Çene Cerrahisi
Bölüm Derleme
Yazarlar

Zeki Mert Çevik 0009-0000-2659-2276

Erkan Erkmen 0000-0002-4746-5281

Şule Kahraman 0000-0001-9454-7733

Yayımlanma Tarihi 20 Mayıs 2024
Gönderilme Tarihi 26 Şubat 2024
Kabul Tarihi 7 Mart 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 13 Sayı: 2

Kaynak Göster

Vancouver Çevik ZM, Erkmen E, Kahraman Ş. Significance of Dental Stem Cells in Dentistry and Stem Cell Banking. ADO Klinik Bilimler Dergisi. 2024;13(2):402-8.