Assessment of Thyroid Hormone Levels in COVID -19 Patients

Öz

OBJECTIVE: As COVID-19 affects many systems, it also affects the endocrine system. In this study, it was aimed to evaluate the relationship between thyroid hormone level and disease severity of patients hospitalized in the COVID-19 service. MATERIALS AND METHODS: Between March 2020 and November 2020 hospitalized patients with positive COVID-19 PCR test and without need for intensive care were evaluated retrospectively. The study included 93 COVID-19 patients and 58 in control group of similar age and gender. Demographic characteristics, thyroid hormone levels and other laboratory values of COVID-19 and control group were compared. Patients with COVID-19 were divided into two groups as those with or without lung involvement according to the chest tomography findings. RESULTS: In the COVID 19 group free T3 and free T4 levels were found to be significantly lower than the control group, while no difference was found between TSH and T3/T4 ratio. In patients with COVID-19 and lung involvement age, aspartate aminotransferase, C-reactive protein and lactate dehydrogenase values were higher; free T3, neutrophil and lymphocyte counts and albumin levels were found to be lower compared to those without lung involvement. There was a correlation between the presence of pneumonia and free T3 levels. CONCLUSION: In the course of COVID-19, thyroid functions can change depending on the severity of the disease. Assessment of thyroid function tests in hospitalized patients may give an idea about the prognosis of the disease.

Anahtar Kelimeler

• thyroid
• COVID-19
• non-thyroidal illness syndrome

COVID -19 Hastalarında Tiroid Hormon Seviyelerinin Değerlendirilmesi

Öz

AMAÇ: COVID-19 birçok sistemi etkilediği gibi endokrin sistemi de etkilemektedir. Bu çalışmada; COVID-19 servisinde yatan hastaların, tiroid hormon düzeyi ile hastalık şidde-ti arasındaki ilişkiyi değerlendirmek amaçlandı. GEREÇ VE YÖNTEM: Mart 2020 ile Kasım 2020 tarihleri arasında COVID-19 PCR testi pozitif saptanıp, hastaneye yatırılan ve yoğun bakım ihtiyacı olmayan hastalar, retrospek-tif olarak değerlendirildi. Çalışmaya 93 COVID-19 hastası ve benzer yaş ve cinsiyette olan 58 kontrol grubu alındı. COVID-19 ve kontrol grubunun demografik özellikleri, tiroid hormon seviyeleri ve diğer laboratuvar değerleri karşılaştırıldı. COVID-19 saptanan has-talar akciğer tomografi bulgularına göre; akciğer tutulumu olanlar ve olmayanlar olarak iki gruba ayrıldı. BULGULAR: COVID 19 grubunda, serbest T3 ve serbest T4 düzeyleri, kontrol grubun-dan anlamlı olarak daha düşük saptanırken, TSH ve T3/T4 oranı arasında fark saptan-madı. COVID-19 olup, akciğer tutulumu eşlik edenlerde, akciğer tutulumu olmayanlara göre; yaş, aspartat aminotransferaz, C- reaktif protein ve laktat dehidrogenaz değerleri daha yüksek, serbest T3, nötrofil ve lenfosit sayısı ile albümin değeri ise daha düşük saptandı. Pnömo-ni varlığı ile serbest T3 seviyeleri arasında ilişki saptandı. SONUÇ: COVID-19 seyri sırasında hastalığın şiddetine bağlı olarak tiroid fonksiyonları değişebilir. Hastanede yatan hastalarda tiroid fonksiyon testlerini ölçmek hastalığın prognozu hakkında fikir verebilir.

Anahtar Kelimeler

• COVID-19
• tiroid
• tiroid dışı hastalık sendromu

Kaynakça

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