Çocukluk çağında Guillain Barre Sendromu: Bir olgu serisi

Yıl 2023, , 48 - 51, 30.04.2023

Arzu Yılmaz , Rabia Meral Olcay Tosun Meriç

https://doi.org/10.20492/aeahtd.1061873

Öz

Amaç: Guillain Barre Sendromu (GBS) hızla ilerleyen, asendan, simetrik zayıflık ve arefleksi ile karakterize akut inflamatuar bir polinöropatidir. Çocukluk çağında akut flask paralizinin en sık nedenidir. Sıklıkla ilerleyici güçsüzlük, ilişkili hafif duyusal semptomlar ve spesifik olmayan enfeksiyondan birkaç gün veya hafta sonra ortaya çıkan albüminositolojik ayrışma ile karakterizedir. Nörolojik defisit günler ve aylar içinde ilerler.
Gereç ve Yöntem: Bu çalışmada 2016-2018 yılları arasında kliniğimize başvuran farklı klinik bulgulara sahip toplam 7 GBS olgusu sunuldu.
Bulgular: İki hastada akut motor aksonal nöropati (AMAN), iki hastada akut inflamatuar demiyelinizan polinöropati (AIDP), bir hastada Miller Fischer sendromu (MFS), bir hastada Bickerstaff beyin sapı ensefaliti (BBE) ve bir hastada atipik tanı konuldu. Guillain Barre sendromu. AMAN'lı olgularda solunum desteği gerekti ve bunlardan birinde ventilatör ilişkili pnömoni ve tansiyon pnömotoraks gelişti.
Sonuç: Tüm olgular sekelsiz iyileşti.

Anahtar Kelimeler

Guillain-Barré Sendromu, çocukluk, AMAN, AIDP, MFS, BBE, Guillain-Barré Sendromu, çocukluk, AMAN, AIDP, MFS, BBE

Guillain Barre Syndrome in childhood: A case series

Öz

Aim: Guillain Barre Syndrome (GBS) is an acute inflammatory polyneuropathy characterized by rapidly progressive, ascending, symmetric weakness and areflexia. It is the most common cause of acute flask paralysis in childhood. It is frequently characterized by progressive weakness, associated mild sensory symptoms, and albuminocytologic dissociation that often occur several days or weeks after nonspecific infection. The neurological deficit progresses in days and months.
Material and Method: In this study, a total of 7 GBS cases with different clinical manifestations admitted to our clinic between 2016 and 2018 were presented.
Results: Two patients were diagnosed with acute motor axonal neuropathy (AMAN), two patient with acute inflammatory demyelinating polyneuropathy (AIDP), one patient with Miller Fischer syndrome (MFS), one patient with Bickerstaff's brainstem encephalitis (BBE)and one patient with atypical Guillain Barre syndrome. The cases with AMAN necessitated respiratory support and ventilator-associated pneumonia and tension pneumothorax developed in one of them.
Conclusion: All cases healed without any sequels.

Anahtar Kelimeler

Guillain-Barré Syndrome, childhood, AMAN, AIDP, MFS, BBE, Guillain-Barré Syndrome, childhood, AMAN, AIDP, MFS, BBE

Kaynakça

• Sejvar JJ, Baughman AL, Wise M and Morgan OW. Population incidence of Guillain-Barre syndrome: a systematic review and meta-analysis. Neuroepidemiology. 2011; 36: 123-33.
• McGrogan A, Madle GC, Seaman HE and de Vries CS. The epidemiology of Guillain-Barre syndrome worldwide. A systematic literature review. Neuroepidemiology. 2009; 32: 150-63.
• Jacobs BC, Rothbarth PH, van der Meche FG, et al. The spectrum of antecedent infections in Guillain-Barre syndrome: a case-control study. Neurology. 1998; 51: 1110-5.
• Wu X, Shen D, Li T, et al. Distinct Clinical Characteristics of Pediatric Guillain-Barre Syndrome: A Comparative Study between Children and Adults in Northeast China. PLoS One. 2016; 11: e0151611.
• Wijdicks EF and Klein CJ. Guillain-Barre Syndrome. Mayo Clin Proc. 2017; 92: 467-79.
• Hughes RA, Swan AV and van Doorn PA. Intravenous immunoglobulin for Guillain-Barre syndrome. Cochrane Database Syst Rev. 2014: CD002063.
• Raphael JC, Chevret S, Hughes RA and Annane D. Plasma exchange for Guillain-Barre syndrome. Cochrane Database Syst Rev. 2012: CD001798.
• Rajabally YA, Durand MC, Mitchell J, Orlikowski D and Nicolas G. Electrophysiological diagnosis of Guillain-Barre syndrome subtype: could a single study suffice? Journal of neurology, neurosurgery, and psychiatry. 2015; 86: 115-9.
• Lee JH, Sung IY and Rew IS. Clinical presentation and prognosis of childhood Guillain-Barre syndrome. J Paediatr Child Health. 2008; 44: 449-54.
• Linden V, da Paz JA, Casella EB and Marques-Dias MJ. Guillain-Barre syndrome in children: clinic, laboratorial and epidemiologic study of 61 patients. Arquivos de neuro-psiquiatria. 2010; 68: 12-7.
• Devos D, Magot A, Perrier-Boeswillwald J, et al. Guillain-Barre syndrome during childhood: particular clinical and electrophysiological features. Muscle Nerve. 2013; 48: 247-51.
• Ye YQ, Wang KR, Sun L and Wang Z. Clinical and electrophysiologic features of childhood Guillain-Barre syndrome in Northeast China. Journal of the Formosan Medical Association = Taiwan yi zhi. 2014; 113: 634-9.
• Gupta PK, Singhi P, Singhi S, Kasinathan A and Sankhyan N. How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India. Indian journal of pediatrics. 2019; 86: 329-34.
• Tekgul H, Serdaroglu G and Tutuncuoglu S. Outcome of axonal and demyelinating forms of Guillain-Barre syndrome in children. Pediatric neurology. 2003; 28: 295-9.
• Bradshaw DY and Jones HR, Jr. Guillain-Barre syndrome in children: clinical course, electrodiagnosis, and prognosis. Muscle Nerve. 1992; 15: 500-6.
• Ropper AH and Kehne SM. Guillain-Barre syndrome: management of respiratory failure. Neurology. 1985; 35: 1662-5.
• Haupt WF. Recent advances of therapeutic apheresis in Guillain-Barre syndrome. Ther Apher. 2000; 4: 271-4.