70 Yaş ve Üzeri Erkek Cinsiyette Kemik Mineral Dansitesinin İnsülin Benzeri Büyüme Faktörü 1 ve Estradiol Düzeyleri ile İlişkisi

Yıl 2023, , 125 - 130, 30.09.2023

Çağatay Emir Önder , Nisbet Yılmaz

https://doi.org/10.20492/aeahtd.1328824

Öz

Amaç: Osteoporoz düşük kemik kütlesi ve kemiğin mikromimarisinin bozulması ile karakterize bir hastalıktır. Kadınlarda osteoporozun daha sıklıkla görülmesi, erkeklerde göz ardı edilmesine yol açmıştır. Bu çalışmanın amacı, 70 yaş ve üzeri erkek cinsiyette kemik mineral dansitesinin insülin benzeri büyüme faktörü 1 (IGF-1) ve Estradiol düzeyleri ile ilişkisini değerlendirmektir.
Gereç ve Yöntem: Çalışma, 2014-2015 arasında 28 hasta (osteoporoz ve osteopeni) ve 23 kontrol grubu olarak 51 kişi ile yapıldı. Vakaların diyette 3 günlük ortalama kalsiyum alımları ve fiziksel aktivite durumları kaydedildi. Kemik mineral yoğunluğu (KMY), albumine göre düzeltilmiş serum kalsiyum düzeyi (Alb-sCa), fosfor (P), paratiroid hormon (PTH), 25 (OH) D3 vitamini, total testesteron, estradiol (E2), IGF-1 ve 24 saatlik idrar Ca düzeyleri ölçüldü.
Bulgular: Hasta ve kontrol grubu arasında yaş, vücut kitle indeksi (BMI), fiziksel aktivite ile Alb-sCa, P, PTH ve 24 saatlik idrar Ca düzeyleri yönünden fark bulunmazken (p>0.05); kontrol grubunun boy, kilo, 3 günlük ortalama kalsiyum alımları ile 25 (OH) D3 vitamini düzeyi anlamlı olarak yüksekti (p<0.05). Hasta grubunun Femur boyun ve Lomber total T skorları ile KMY kontrol grubuna göre daha düşüktü (p<0,05). Kontrol grubunun IGF-1 düzeyi 113,41±36,50 ng/ml iken hasta grubunun 99,62±35,20 ng/ml ölçüldü ancak fark istatistiksel olarak anlamlı bulunmadı (p=0.17). E2 düzeyi hasta grubunda 26,14±18,07 pmol/L, kontrol grubunda 35,83±15,49 pmol/L olup hasta grubunda anlamlı düşük görüldü (p=0,04). E2 düzeyinin Lomber total T skoru ile arasında anlamlı pozitif yönlü ilişki bulundu (p=0.02).
Sonuç: Çalışmamızda gruplar arasında IGF-1 düzeyleri arasında anlamlı fark saptanmazken, E2’nin KMY üzerine etkisi aşikar bulunmuştur. Herhangi bir nedenle E2 düzeyi düşük erkeklerde KMY’nin azalacağı unutulmamalıdır.

Anahtar kelimeler: Erkek, Osteoporoz, İnsülin benzeri büyüme faktörü 1, Estradiol.

Anahtar Kelimeler

Erkek, Osteoporoz, İnsülin benzeri büyüme faktörü 1, Estradiol.

The Relationship of Bone Mineral Density with Insulin-like Growth Factor 1 and Estradiol Levels in Males Aged 70 and Over

Öz

Aim: Osteoporosis is a disease characterized by low bone mass and deterioration of bone microarchitecture. The higher incidence of osteoporosis in women has led to its being overlooked in men. The aim of this study was to evaluate the relationship between bone mineral density and insulin-like growth factor 1 (IGF-1) and Estradiol levels in men aged 70 years and over.
Material-Method: The study was conducted between 2014-2015 with 28 patients (osteoporosis and osteopenia) and 51 people as 23 control groups. The 3-day average dietary calcium intake and physical activity status of the cases were recorded. Bone mineral density (BMD), albumin-corrected serum calcium level (Alb-sCa), phosphorus (P), parathyroid hormone (PTH), vitamin 25 (OH) D3, total testosterone, estradiol (E2), IGF-1 and 24 hourly urinary Ca levels were measured.
Results: While there was no difference between the patient and control groups in terms of age, body mass index (BMI), physical activity, Alb-sCa, P, PTH and 24-hour urinary Ca levels (p>0.05); Height, weight, 3-day average calcium intake and 25 (OH) D3 vitamin levels of the control group were significantly higher (p<0.05). Femur neck and Lumbar total T scores and BMD of the patient group were lower than the control group (p<0.05). While the IGF-1 level of the control group was 113.41±36.50 ng/ml, it was 99.62±35.20 ng/ml in the patient group, but the difference was not statistically significant (p=0.17). E2 level was 26.14±18.07 pmol/L in the patient group and 35.83±15.49 pmol/L in the control group, which was significantly lower in the patient group (p=0.04). A significant positive correlation was found between E2 level and Lumbar total T score (p=0.02).
Conclusion: While no significant difference was found between the groups in IGF-1 levels in our study, the effect of E2 on BMD was found to be obvious. It should be noted that BMD will decrease in men with a low E2 level for any reason.

Keywords: Male, Osteoporosis, Insulin-like growth factor 1, Estradiol.

Anahtar Kelimeler

Male, Osteoporosis, Insulin-like growth factor 1, Estradiol.

Kaynakça

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