Evaluation of patients receiving narrow-band ultraviolet B phototherapy for early stage Mycosis fungoides

Yıl 2024, , 110 - 113, 22.01.2025

Berkay Temel , İpek Kara , Nermin Karaosmanoğlu

https://doi.org/10.20492/aeahtd.1472165

Öz

Aim: To examine the demographic characteristics, disease prevalence, histopathological findings, phototherapy treatment data and responses of patients receiving narrow-band ultraviolet B (nbUVB) phototherapy for early-stage mycosis fungoides (MF).
Material and methods: Patients with a clinically and histopathologically confirmed diagnosis of MF who received dbUVB monotherapy for at least 12 weeks in the phototherapy unit of a tertiary healthcare institution between February 2020 and February 2024 were included in this study. The evaluation variables for the study were age, gender, presence of pruritus, previous treatments, time to diagnosis, body involvement areas, histopathological findings, total dose of phototherapy, number of phototherapy sessions, phototherapy response, phototherapy side effects. The variables were analysed statistically.
Results: Data of 50 patients were included in the study. The mean age of the patients was 50.1±17.8 years. 50% (n=25) of the patients were male and 50% (n=25) were female. The mean duration of diagnosis was 75.37±9.05 months. Itching symptom was reported in 30% (n=15) of the patients. 58% (n=29) of the patients had a complete response to treatment. The mean duration of treatment was 14.2±7.2 months. Patients received a median of 121 (36-324) sessions of dbUVB treatment. 65.6% (n=21) of stage 1A patients and 44.4% (n=8) of stage 1B patients benefited from the treatment. Mild erythema and pruritus side effects were observed in 42% (n=21) of the patients.
Conclusion: NbUVB phototherapy is an effective treatment modality for early stage MF with a reliable side effect profile.

Anahtar Kelimeler

cutaneous, lymphoma, treatment

Erken evre Mikozis fungoides nedeniyle darband ultraviyole B fototerapisi alan hastaların değerlendirilmesi

Öz

ÖZET
Amaç: Bu çalışmanın amacı, erken evre Mikozis fungoides (MF) nedeniyle darband ultraviyole B (dbUVB) fototerapisi alan hastaların demografik özellikleri, hastalık yaygınlıkları, histopatolojik bulguları, fototerapi tedavi verileri ve yanıtlarının incelenmesidir.
Gereç ve yöntem: Bu çalışmaya Şubat 2020 ile Şubat 2024 yılları arasında üçüncü basamak bir sağlık kuruluşunun fototerapi ünitesinde, klinik ve histopatolojik olarak MF tanısı doğrulanmış ve en az 12 hafta dbUVB monoterapisi alan hastalar kabul edildi. Çalışma için değerlendirme değişkenleri; yaş, cinsiyet, kaşıntı varlığı, daha önceki tedaviler, tanı alma süresi, vücut tutulum alanları, histopatolojik bulgular, fototerapi toplam dozu, fototerapi seans sayısı, fototerapi yanıtı, fototerapi yan etkileri olarak seçilmiştir. Değişkenler istatistiksel olarak analiz edilmişti.
Bulgular: Çalışmaya 50 hastanın verileri dahil edildi. Hastaların yaş ortalaması 50,1±17,8’di Hastaların %50’si (n=25) erkekti, %50’si (n=25) kadındı. Hastaların ortalama tanı alma süreleri 75,37±9,05 aydı. Kaşıntı semptomu hastaların %30’unda (n=15) bildirilmişti. Hastaların %58’i (n=29) tedaviden tam yanıt aldı. Hastaların ortalama tedavi süreleri 14,2±7,2 aydı. Hastalar median 121 (36-324) seans dbUVB tedavisi almıştı. Evre 1A olan hastaların %65,6’sı (n=21), Evre 1B olan hastaların %44,4’ü (n=8) tedaviden fayda görmüştü. Hastaların %42’sinde (n=21) hafif eritem ve pruritus yan etkisi görülmüştü.
Sonuç: DbUVB fototerapisi erken evre MF için efektif ve yan etki profili güvenilir bir tedavi yöntemidir.
Anahtar kelimeler: kutanöz, lenfoma, tedavi

Anahtar Kelimeler

kutanöz, lenfoma, tedavi

Kaynakça

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