Tip 1 Diyabet Mellitus'ta Mikrovasküler Komplikasyonların Tahmininde HALP Skorunun Etkinliği.

Yıl 2025, Cilt: 58 Sayı: 3, 120 - 125, 24.02.2026

Burcu Candemir , Burak Menekşe , Burçak Cavnar Helvacı , Erman Çakal

https://izlik.org/JA55GN77XY

Öz

Amaç. Tip 1 diabetes mellitus'un (T1DM) mikrovasküler komplikasyonları önemli bir morbidite ve mortalite nedenidir. Artan kanıtlar, inflamasyon ve beslenmenin diyabetik mikrovasküler komplikasyonların gelişiminde önemli bir rol oynadığını göstermektedir. Bu çalışmanın amacı, T1DM'li hastalarda immünnütrisyonel durumun değerli bir göstergesi olan Hemoglobin, Albümin, Lenfosit ve Trombosit (HALP) skoru ile üç diyabetik mikrovasküler komplikasyon arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem. Çalışmaya toplam 193 T1DM hastası dahil edildi ve retrospektif olarak değerlendirildi. Sosyodemografik ve klinik veriler anamnez ve tıbbi kayıtlardan elde edildi. Biyokimyasal parametreler standart laboratuvar yöntemleriyle ölçüldü. Mikrovasküler komplikasyonlar güncel kılavuzlara göre değerlendirildi. Tüm hastaların HALP skorları hesaplandı.
Bulgular. Mikrovasküler komplikasyonları olan ve olmayan hastalar arasında yaş, cinsiyet ve vücut kitle indeksi açısından anlamlı bir fark saptanmadı. Diyabetik böbrek hastalığı (DKD) grubunun ortalama HALP skoru, DKD olmayan gruba kıyasla anlamlı derecede düşüktü (40,66 ± 9,31 vs. 52,30 ± 15,14, p <0,001). Diyabetik retinopati (DR) grubunun ortalama HALP skoru, DR olmayan gruba kıyasla anlamlı derecede düşüktü (38,58 ± 9,35 vs. 52,07 ± 14,75, p <0,001). Diyabetik nöropati (DN) grubunda ortalama HALP skoru, DN olmayan gruba kıyasla daha düşüktü (43,33 ± 12,53 vs. 52,47 ± 14,97, p <0,001). Her üç mikrovasküler komplikasyonun varlığı HALP skoru ile negatif korelasyon gösterdi.
Sonuç. Bulgularımız, T1DM'li hastalarda daha düşük HALP skoru değerlerinin diyabetik mikrovasküler komplikasyonların varlığıyla ilişkili olabileceğini düşündürmektedir. Bilgilerimize göre bu, T1DM'li hastalarda üç kronik mikrovasküler komplikasyon ile HALP skoru arasındaki ilişkiyi araştıran ilk çalışmadır.
Anahtar Kelimeler: Diyabetik böbrek hastalığı, diyabetik nöropati, diyabetik retinopati, HALP skoru, Type 1 diabetes mellitus.

Anahtar Kelimeler

Diyabetik böbrek hastalığı , diyabetik nöropati , diyabetik retinopati , HALP skoru , Type 1 diabetes mellitus

Etik Beyan

Bu çalışma Helsinki Bildirgesi’ne uygun olarak yürütülmüş ve Etlik Şehir Hastanesi Kurumsal Etik Kurulu tarafından onaylanmıştır. (Onay no: 2025/368; Tarih: 05.08.2025).

Destekleyen Kurum

Yoktur.

Teşekkür

Bu araştırma kamu, ticari veya kâr amacı gütmeyen sektördeki herhangi bir fon kuruluşundan özel bir hibe almamıştır.

The Utility of the HALP Score in Predicting Microvascular Complications in Type 1 Diabetes Mellitus.

https://izlik.org/JA55GN77XY

Öz

Aim. Microvascular complications of type 1 diabetes mellitus (T1DM) are a significant cause of morbidity and mortality. Increasing evidence suggests that inflammation and nutrition play an important role in the development of diabetic microvascular complications. The aim of the present study was to investigate the association between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, a valuable indicator of immunonutritional status, and three diabetic microvascular complications in patients with T1DM.
Material and Method. A total of 193 patients with T1DM were included and retrospectively evaluated. Sociodemographic and clinical data were obtained from medical records. Biochemical parameters were measured with standard laboratory methods. Microvascular complications were evaluated according to current guidelines. The HALP scores of all patients were calculated.
Results. No significant differences were found between patients with and without microvascular complications in terms of age, gender, and BMI. The mean HALP score of the diabetic kidney disease (DKD) group was significantly lower compared to the non-DKD group (40.66±9.31 vs. 52.30±15.14, p<0.001). The mean HALP score of the diabetic retinopathy (DR) group was significantly lower compared to the non-DR group (38.58±9.35 vs. 52.07±14.75, p<0.001). The mean HALP score was lower in the diabetic neuropathy (DN) group than in the non-DN group (43.33±12.53 vs. 52.47±14.97, p<0.001). The presence of all three microvascular complications was negatively correlated with the HALP score.
Conclusions. Our findings suggest that a reduced HALP score may be associated with the presence of diabetic microvascular complications in patients with T1DM. To our knowledge, this is the first study to investigate the relationship between three chronic microvascular complications and HALP scores in patients with T1DM.
Keywords: Diabetic kidney disease, diabetic neuropathy, diabetic retinopathy, HALP score, Type 1 diabetes mellitus.

Anahtar Kelimeler

Diabetic kidney disease , diabetic neuropathy , diabetic retinopathy , HALP score , Type 1 diabetes mellitus.

Etik Beyan

This study was conducted in accordance with the Declaration of Helsinki and was approved by the institutional ethics committee of Etlik City Hospital (Approval no: 2025/368; Date: 05.08.2025).

Destekleyen Kurum

None.

Teşekkür

This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.

Kaynakça

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