EVALUATION OF METABOLIC SYNDROME IN PATIENTS WITH ALOPECIA AREATA

Öz

OBJECTIVE: The increase of diabetes mellitus prevelance and insulin resistance have been reported in patients with alopecia areata AA . Despite androgenetic alopecia as a potential condition for MetS, our knowledge for MetS is limited in alopecia areata AA . The aim of this study is to investigate the association between MetS and AA.MATERIAL AND METHODS: This study is a case-control study including 66 patients with AA and 60 age and gender-matched controls. Demographic, clinical and laboratory features of patients and controls were compared. Odds ratios OR were estimated using a logistic regression analysis. Pearson or Spearman test were used for correlation.RESULTS: MetS was identified in 12 18.2% subjects with AA and 10 16.7% subjects without AA p=0.87 . For metabolic syndrome, age 1.3 fold was found as independent risk factors in a multivariate analysis Age: p=0.001, OR 95% CI = 1.3 1.1-1.6 . Positive moderate correlation was found between age and presence of metabolic syndrome r=0.56, p=0.01 .CONCLUSION: The increased risk of MetS development in patients with AA was not determined in our study. Local involvement of AA rather than systemic involvement may be effective on this result. Development risk of MetS has been increasing with age. In our study, increase in age was the most significant independent risk factor for the development of MetS. We believe that screening of elders with disseminated involvement and long duration of disease rather than youngers with local involvement and short duration of disease would be more useful for early diagnosis and reduction in morbidity and mortality of MetS in AA

Anahtar Kelimeler

• alopecia areata,metabolic syndrome,risk factors

ALOPESİ AREATA HASTALARINDA METABOLİK SENDROMUN DEĞERLENDİRİLMESİ

Öz

AMAÇ: Alopesi areata AA hastalarında diabetes mellitus sıklığının ve insülin direncinin arttığı bildirilmiştir. Androgenetik alopeside metabolik sendrom MetS sıklığının arttığı bilinmesine rağmen, alopesi areatada bilgilerimiz kısıtlıdır. Bu çalışmanın amacı AA ile MetS arasındaki ilişkiyi araştırmaktır.GEREÇ VE YÖNTEMLER: Bu çalışma 66 AA’lı hasta ve 60 yaş-cinsiyet uyumlu kontrol içeren olgu-kontrol çalışmasıdır. Hasta ve kontrollerin demografik, klinik ve laboratuvar özellikleri karşılaştırıldı. Göreceli olasılıklar oranı OR lojistik regresyon analizi kullanılarak değerlendirildi. Korelasyon için Pearson veya Spearman testleri kullanıldı.BULGULAR: MetS, AA’sı olan 12 %18.2 ve olmayan 10 %16.7 katılımcıda tespit edildi p=0.87 . MetS için, yaş 1.3 kat çok değişkenli analizde bağımsız risk faktörü olarak bulundu Yaş: p=0.001, TRR %95 GA = 1.3 1.1-1.6 . Yaş ile MetS arasında orta derece pozitif korelasyon bulundu r=0.56, p=0.01 .SONUÇ: Çalışmamızda AA hastalarında MetS gelişmesi ile ilgili artmış bir risk saptanmadı. Alopesi areatanın sistemikten ziyade lokal tutulum yapması bu sonuçta etkili olabilir. MetS gelişme riski yaşla birlikte artmaktadır. Bizim çalışmamızda yaşta artış MetS gelişmesi açısından en önemli bağımsız faktördü. Lokal tutulumu olan, hastalık süresi kısa, yeni tanı genç hastalardan ziyade yaygın tutulumu olan, uzun hastalık süresine sahip ileri yaşta ki AA hastalarında MetS taramalarının yapılmasının genel olarak MetS’un erken tanısı ve mortalite-morbiditesinin azaltılmasında daha faydalı olacağını düşünmekteyiz

Anahtar Kelimeler

• alopesi areata,metabolik sendrom,risk faktörleri

Kaynakça

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