THE RELATIONSHIP BETWEEN ARTERIAL CALCIFICATIONS DETECTED ON MAMMOGRAPHY AND EARLY HYPERTENSIVE RETINOPATHY

Öz

OBJECTIVE: The purpose of this study was to investigate the association between the arterial calcifications detected on mammography and with the presence of hypertension HT and hypertensive retinopathy HTRP in premenopausal women.MATERIAL AND METHODS: Between January and June 2012 the women who had arterial calcifications on mammography after having mammography for screening or diagnostic reasons were included. Thirty cases whose age range was between 40 to 55 years were examined. Hypertension was clarified after serial measurements and after internal medicine or cardiology consultations. The arterial pressure levels above 140/90mmHg was considered as HT. All patients were evaluated in terms of HTRP in ophtalmology department with biomicropscopy. Statistical analysis was performed using SPSS 15.0 for Windows SPSS, Inc., Chicago, IL . Fisher’s exact test was used.RESULTS: The mean age of the 30 patients in the study was 50.6 ± 3.3. In 14 cases 46.6% hypertension was present. In 9 patients 30% HTRP was detected. Of those 9 patients, 7 77.7% were stage 1 and 2 patients 22.3% had stage 2 as HTRP. Of the cases with HTRP, 8 of them were hypertensive. When evaluating patients without HT only in one patient with stage 1 HTRP was present. In patients who had aterial calcifiabtions in breast there was a significant relation between the presence of HTRP and HT. P

Anahtar Kelimeler

• hypertension,retinopathy,breast,mammography,arterial calcification

MAMOGRAFİDE SAPTANAN ARTERİYEL KALSİFİKASYONLARIN ERKEN HİPERTANSİF RETİNOPATİ İLE İLİŞKİSİ

Öz

AMAÇ: Bu çalışmanın amacı, menopoz öncesinde mamografide saptanan arteriyel kalsifikasyon MAK varlığı ile hipertansiyon HT ve hipertansif retinopati HTRP birlikteliğini araştırmaktır.GEREÇ VE YÖNTEMLER: Ocak 2012- Haziran 2012 tarihleri arasında tarama ya da tanısal amaçlı mamografi çekimi yapılan ve mamografisinde arteriyel kalsifikasyonları mevcut olan olgular dahil edildi. Yaş aralığı 40-55 yaş olan 30 olgu incelendi. Hipertansiyon varlığı ölçümler sonucunda ve dahiliye veya kardiyoloji kliniklerince konsülte edilerek netleştirildi. Arteriyel tansiyon ölçümleri 140/90mmHg üzeri olanlar HT olarak kabul edildi. HTRP açısından tüm olgular biyomikroskopik muayene ile göz kliniğinde değerlendirildi. İstatiksel analizde SPSS 15.0 for Windows SPSS, Inc., Chicago, IL . Fisher’in kesin olasılık testi kullanıldı.BULGULAR: Çalışmadaki 30 hastanın ortalama yaşı 50.6±3.3 idi. Olguların 14’ünde %46.6 HT mevcuttu. Dokuz hastada %30 HTRP tespit edildi. Dokuz hastanın 7’si %77.7 evre 1, 2 hasta %22.3 evre 2 HTRP olarak saptandı. HTRP tespit edilen olgulardan 8 tanesi hipertansifti. HT olmayan olgular değerlendirildiğinde sadece bir olguda evre 1 HTRP tespit edildi. Memede arteriyel kalsifikasyonu mevcut olan olguların HTRP varlığı ve HT varlığı açısından anlamlı ilişki saptandı. p

Anahtar Kelimeler

• Hipertansiyon,retinopati,meme,mamografi,arteriyel kalsifikasyon

Kaynakça

1. 1)Cetin M, Cetin R, Tamer N. Prevalence of breast arterial calcification in hypertensive patients. Clin Radiol. 2004; 59: 92-5.
2. 2)Micheletti RG, Fishbein GA, Currier JS, Fishbein MC. Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis. Arch Pathol Lab Med. 2008; 132: 43-7.
3. 3)Iribarren C, Go AS, Tolstykh I, Sidney S, Johnston SC, Spring DB. Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure. J Womens Health (Larchmt). 2004; 13: 381-9.
4. 4)Kemmeren JM, van Noord PA, Beijerinck D, Fracheboud J, Banga JD, van der Graaf Y. Arterial calcification found on breast cancer screening mammograms and cardiovascular mortality in women: the DOM Project. Doorlopend Onderzoek Morbiditeit en Mortaliteit. Am J Epidemiol. 1998; 147: 333-341.
5. 5)Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med. 2004; 25: 2310-7.
6. 6)Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology. 1982; 89: 1132-1145.
7. 7)Walsh JB: Hypertensive retinopathy: Description, classification, and prognosis. Ophthalmology. 1982; 89: 1127-31.
8. 8)American College of Radiology. ACR BI-RADS Atlas, Breast Ultrasound (http://www.acr.org/~/media/ACR/Documents/PDF/QualitySafety/Resources/BIRADS/02%20Ultrasound/05%20%20BIRADS%20US%20Reporting.pdf)

9. 9)Cetin M, Cetin R, Tamer N, Kelekci S. Breast arterial calci fications associated with diabetes and hypertension. J Diabetes Complications. 2004; 18: 363-366.
10. 10)Moshyedi AC, Puthawala AH, Kurland RJ, O’Leary DH. Breast arterial calcification: association with coronary artery disease. Radiology. 1995; 194: 181-183.
11. 11)Kemmeren JM, Beijerinck D, van Noord PA, Banga JD, Deurenberg JJ, Pameijer FA, et al. Breast arterial calcifications: association with diabetes mellitus and cardiovascular mortality. Radiology. 1996; 201: 75-78.
12. 12)Baum JK, Comstock CH, Joseph L. Intramammary arterial calcifications associated with diabetes. Radiology. 1980; 136: 61-62.
13. 13)Taşkin F, Akdilli A, Karaman C, et al. Mammographically detected breast arterial calcifications: indicators for arteriosclerotic diseases? Eur J Radiol. 2006; 60: 250–255.
14. 14)Calisir C, Yavas US, Erol N. The relationship between the breast arterial calcification detected by mammography and the hypertensive retinopathy in hypertensive women. Korean J Radiol. 2008 Jul-Aug;9(4):320-4. doi: 10.3348/ kjr.2008.9.4.320.
15. 15)Markopoulos C, Mantas D, Revenas K, Kouskos E, Tzonou A, Liapis C, Kostakis A. Breast arterial calcifications as an indicator of systemic vascular disease. Acta Radiol. 2004; 45: 726-9.
16. 16)Saá J1, Fernández-Guinea O, García-Pravia P, Fernandez-Garcia B, Eiró N, del Casar JM, Venta R, Baamonde B, Vizoso FJ. Relationship between breast arterial calcifications seen on screening mammograms and age-related macular degeneration. Acta Ophthalmol. 2014; 92: e582-4.