Nazolakrimal Sistemin Primer Mukozal Malign Melanomu

Yıl 2017, Cilt: 50 Sayı: 3, 156 - 160, 01.12.2017

SÜMEYRA Doluoğlu , Aydın Acar , Serdar Özer , Gülüşan Ergül Adil Eryılmaz

Öz

Nazolakrimal sistemin mukozal malign melanomu nadir görülür
ve son derece agresiv seyreder.  Bu tümörler kendini epifora, kanlı
gözyaşı, epistaksis ve  tümör büyüdükçe de kitle  oluşturarak belli
eder. Literatür incelendiğinde bu tümörlere ait çalışmalar oldukça az
sayıdadır. Bizim vakamız  3 aydır devam eden sol gözde kanlı sulanma ve 2
aydır burun kanaması şikayeti olan, 92 yaşında erkek hasta idi. Nazal
endoskopide alt meatusta görülen kitleden alınan biyopsi ile nazolakrimal
sistem malign melanomu tanısı konulup, literatür eşliğinde tartışılmıştır.

Anahtar Kelimeler

Malign melanom, nazolakrimal sistem, epistaksis

Primary Mucosal Malignant Melanoma of the Nasolacrimal System

Öz

Mucosal
malignant melanoma of the nasolacrimal system is rare and usually has an
aggressive clinical course. These tumors present themselves with epiphora,
bloody tears and epistaxis, and as the tumor grows, with a mass. Regarding
these tumors, the number of studies in the literature is relatively small in
number. Our case was a 92-year-old male who had presented with bloody lacrimation
in the left eye for the previous three months and epistaxis for the previous
two months. The histopathological diagnosis of the biopsy obtained from the
mass observed at the inferior meatus during nasal endoscopy was “Malignant
melanoma of the nasolacrimal system”. The patient is presented under the light
of  the relevant literature. 

Anahtar Kelimeler

Malignant melanoma, nasolacrimal system, epistaxis

Kaynakça

• 1. Evans RD, Kopf AW, Lew RA et al. Risk factors for the development of malignant melanoma. I: review of the case-control studies. J Dermatol Surg Oncol. 1988;14:393-408.
• 2. Snow G, Vander Waal I. Mucosal melanomas of the head and neck. Otolaryngol Clin North Am. 1986;19:537-547.
• 3. Batsakis JG, Suarez P. Mucosal melanomas: a review. Adv Anat Pathol. 2000;7:167-180.
• 4. Schroeder W. Intranasal melanoma. Mo Med. 1992;89:294-297.
• 5. Yamade S, Kiragawa A. Malignant melanoma of the lacrimal sac. Ophthalmologica. 1978;177:30-33.
• 6. Levine MR, Dinar Y, Davies R. Malignant melanoma of the lacrimal sac. Ophthalmic Surg Lasers. 1996;27:318-320.
• 7. Briele H, Walker M, Das Gupta T. Melanoma of the head and neck. Clin Plast Surg. 1985;12:495-503.
• 8. Zak F, Lawson W. The presence of melanocytes in the nasal cavity. Ann Otolaryngol. 1974;83:515-519.
• 9. Conley J, Pack G. Melanoma of the mucous membranes of the head and neck. Arch Otolaryngol. 1974;99:315-319.
• 10. Holmstrom M, Lund V. Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde. Br J Ind Med. 1991;48:9-11.
• 11. Holdcraft J, Gallagher J. Malignant melanomas of the nasal and paranasal sinus mucosa. Ann Otolaryngol Rhinol Laryngol. 1969;78:1-20.
• 12. Pe’er JJ, Stefanysyn M, Hidayat AA. Nonepithelial tumours of the lacrimal sac. Am J Ophthalmol. 1994;118:650-658.
• 13. Stefanysyn MA, Hidayat AA, Pe’er JJ, Flanagan JC. Lacrimal sac tumours. Ophthalmic Plast Reconstr Surg. 1994;10:169-184.
• 14. Esteban F, Gonzalez-Perez JM, Benaıxa JP et al. Malignant melanomas of the nasolacrimal duct. The J Laryng Otology. 2007;121:285-288.
• 15. Lewis AM, Clarke PM, Olver JM. Primary nasolacrimal duct malignant mucosal melanoma. Br J Ophthalmol. 2006;90:114-115.
• 16. Owens JM, Roberts DB, Myers JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Arch Otolaryngol Head Neck Surg. 2003;129:864-868.
• 17. Lund V, Howard D, Harding L, Wei WI. Management options and survival in malignant melanoma of the sinonasal mucosa. Laryngoscope. 1999;109:208-211.
• 18. Gilligan D, Slevin N. Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses. Br J Radiol. 1991;64:1147-1150.
• 19. Seo W, Ogasawara H, Sakagani M. Chemohormonal therapy for malignant melanomas of the nasal and paranasal mucosa. Rhinology. 1997;35:19-21.
• 20. Owens RM, Wax MK, Kostik D, Linberg JV, Hogg J. Malignant melanoma of the lacrimal sac. Otolaryngol Head Neck Surg. 1995;113:634-640.