TÜRKİYE’NİN DOĞU BÖLGESİNDE 25-HİDROKSİ VİTAMİN SEVİYESİ İLE DİSLİPİDEMİ VE İNSÜLİN REZİSTASINI ARASINDAKİ İLİŞKİ

Yıl 2018, Cilt: 51 Sayı: 2, 90 - 97, 29.08.2018

Gül Gürsoy

Öz

Amaç:
D vitamini eksikliği ve yetersizliğinin birçok kronik hastalık ile ilişkili
olduğu kabul edilmektedir. D vitamini, dislipidemi ve insülin
direnci arasındaki ilişki, ilgili hastalıkların erken teşhisi ve tedavisini
sağlayabileceğinden, bu çalışmada D vitamini düzeyleri ile dislipidemi ve
insülin direnci arasındaki ilişkiyi araştırmayı amaçladık.

Gereç
ve yöntemler: Çalışma 249 sağlıklı kişi ile
gerçekleştirilmiştir. Vitamin D dahil olmak üzere laboratuvar testleri yapıldı.
İnsülin direnci, homeostaz model değerlendirme- insülin direnci indeksi ile
hesaplandı. Ayrıca çeşitli vitamin D düzeyleri ile yaş, cinsiyet, glikoz ve
lipit parametreleri ile insülin direnci arasındaki ilişkiyi araştırdık.

Bulgular:
Katılımcıların D vitamini düzeyi erkeklerde  kadınlara göre daha yüksekti. Vitamin D
seviyeleri yaş arttıkça azaldı. Katılımcıların% 3.6'sında normal D vitamini
düzeyleri,% 14.5'inde yetersizlik, % 45.0'ında eksiklik, % 36.9'unda ciddi
eksiklik saptandı.  İnsülin direnci,
ciddi yetersizliği olanların % 57.6'sında, yetersizliği olanların% 22.3'ünde ve
eksikliği olanların% 8.3'ünde saptandı. Normal D vitamini seviyeleri olanların
hiçbiri insülin direncine sahip değildir. D vitamini grupları arasında lipid
parametresi değerleri açısından anlamlı fark bulunmadı. D vitamini azaldıkça
açlık kan şekeri ve insülin değerleri arttı.

Sonuç:
 Sonuç olarak,  D vitamini, dislipidemi ve insülin direnci
birbirinden bağımsız olarak kabul edilemez. D vitamini taraması ile eksik
bulunanlar için erken müdahaleler  metabolik
sendrom, dislipidemi, diyabet ve obezite gibi diğer hastalıkları önleyebilir.

 

Anahtar Kelimeler

Vitamin D, Insulin resistance

Kaynakça

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