Monocyte to HDL-Cholesterol Ratio in Male with Hypogonadotropic Hypogonadism

Yıl 2019, Cilt: 52 Sayı: 2, 128 - 132, 31.07.2019

Kenan Çadırcı , İsra Oğuz Tuba Usta Havva Keskin Ayşe Çarlıoğlu Şenay Arıkan

Öz

Purpose: Previous studies have shown that idiopatic hypogonadotropic hypogonadism (IHH)
patients with low testosterone levels lead to an impaired glucose metabolism,
and an increased cardiovascular risk.  Monocyte to high-density lipoprotein
cholesterol (HDL-C) ratio (MHR) also has been shown to be an indicator of
inflammation and cardiovascular risk. 
The purpose of the present study is to investigate MHR in the male with
IHH. 

Material
and Methods: This study
includes 31 men with IHH without previous treatment for the disease and 44
healthy men.  The blood
sampling, anthropometric measures, and physical examination were undertaken by
all the participants.

Results: Mean ages of the
IHH patients and the healty controls were 22.5±7.2 years vs. 22.9±6.4
years.  There was no statistically
significant difference between the patients and controls in terms of the mean
HDL-C, mean monocyte count, and mean MHR. 
The MHR also was not correlated with the other hematological parameters,
inflammatory parameters, and the total testosterone level.

Conclusion: MHR has been shown to be an indicator of
cardiovascular risk in previous studies but we could not detect an increased
MHR value in patients with IHH In this study.

Anahtar Kelimeler

Monocyte, HDL-cholesterol, inflammation, Idiopathic hypogonadotropic hypogonadism

Erkek İdiopatik Hipogonadotropik Hipogonadizmli Hastalarda Monosit/ HDL oranı

Öz

Amaç: Önceki çalışmalar, düşük testosteron düzeylerine
sahip idiopatik hipogonadotropik hipogonadizm (İHH) hastalarında bozulmuş
glukoz metabolizmasına ve artmış kardiyovasküler riske yatkınlık olduğunu
göstermiştir. Monosit/yüksek yoğunluklu lipoprotein kolesterol (HDL-C) oranı
(MHR) de inflamasyon ve kardiyovasküler risk göstergesi olarak gösterilmiştir.
Bu çalışmanın amacı, İHH tanılı erkek hastalarda MHR'yi araştırmaktır.

Gereç ve Yöntemler:  Bu çalışmaya daha önce tedavi
almamış İHH tanısı olan 31 erkek hasta ve sağlıklı 44 erkek hasta dahil edildi.
Tüm katılımcıların
kan örneklemesi, antropometrik ölçümleri ve fizik muayeneleri yapıldı.

Bulgular: İHH hastalarının yaş
ortalaması 22,5±7,2 yıl ve sağlıklı kontrollerin yaş ortalaması ise 22,9±6,4
yıl idi. Hastalar ve kontroller arasında ortalama HDL-kolesterol, ortalama
monosit sayısı ve ortalama MHR açısından istatistiksel olarak anlamlı bir fark
yoktu. MHR ayrıca diğer hematolojik parametreler, enflamatuar parametreler ve
toplam testosteron seviyesi ile korele değildi.

Sonuçlar:  Önceki çalışmalarda MHR'nin kardiyovasküler riskin bir göstergesi olduğu
gösterilmiştir, ancak bu çalışmada İHH hastalarında artmış bir MHR değeri
tespit edemedik.

Anahtar Kelimeler

Monosit, HDL kolesterol, inflamasyon, idiopatik hipogonadotropik hipogonadizm

Kaynakça

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