TİP 2 DİYABETES MELLİTUS HASTALARINDA ORTALAMA TROMBOSİT HACMİ İLE NÖROPATİ ARASINDAKİ İLİŞKİ

Fatih Güngör; Gül Gürsoy; Aslı Araz Güngör; Seyit Murat Bayram; Eray Atalay; Mehmet Serhat Bayhan

THE RELATIONSHIP OF MEAN PLATELET VOLUME WITH NEUROPATHY IN TYPE 2 DIABETES MELLITUS

Yıl 2016, Cilt: 49 Sayı: 1, 10 - 19, 01.03.2016

Fatih Güngör Gül Gürsoy Aslı Araz Güngör Seyit Murat Bayram Eray Atalay Mehmet Serhat Bayhan

Öz

OBJECTIVE: Diabetic patients have an increased risk of developing micro and macrovascular complications. One of them is neuropathy, whose pathophysiological causes have not yet been absolutely understood. Platelet morphology and function are still been investigated about this topic. In this study we aimed to investigate the association of mean platelet volume with diabetic neuropathy. MATERIAL AND METHODS: Mean platelet volume levels were investigated and compared in type 2 diabetic patients with and without neuropathy and healthy participants. We then seeked the relation of mean platelet volume with hypertension, hyperlipidemia, hemoglobin A1c and body mass index in our diabetic patients. RESULTS: Mean platelet volume levels were the highest in our diabetic patients with neuropathy. In neuropaty negative and positive diabetic patients, existence of hypertension, hyperlipidemia and hypertension with hyperlipidemia did not changed mean platelet volume levels. Also mean platelet volume levels did not correlate with hemoglobin A1c and body mass index in all our groups. CONCLUSION: We think that large platelets may have an important role in complications of diabetes, especially in diabetic neuropathy. We may also say that in diabetics hypertension, hyperlipemia, obesity, control of diabetes were not related with mean platelet volume

Anahtar Kelimeler

Neuropathy, Type 2 Diabetes Mellitus, Mean platelet volume

Kaynakça

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)Vinocour PD. Platelet abnormalities in diabetes mellitus. Diabetes. 1992; 41: 26-31.
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)Zhong ZL, Han M, Chen S. Risk factors associated with retinal neovascularisation of diabetic retinopathy in type 2 diabetes mellitus. Int J Ophtalmol. 2011; 4: 182-5.
)Tuzcu AE, Arıca S, İlhan N et al. Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes. Graefes Arch Clin exp Ophtalmol. 2014; 252: 237-40.
)Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011; : 358-60.
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TİP 2 DİYABETES MELLİTUS HASTALARINDA ORTALAMA TROMBOSİT HACMİ İLE NÖROPATİ ARASINDAKİ İLİŞKİ

Yıl 2016, Cilt: 49 Sayı: 1, 10 - 19, 01.03.2016

Fatih Güngör Gül Gürsoy Aslı Araz Güngör Seyit Murat Bayram Eray Atalay Mehmet Serhat Bayhan

Öz

AMAÇ: Diyabetik hastalarda mikro ve makrovasküler komplikasyon gelişme riski yüksektir. Bunlardan biri, patofizyolojik nedeni henüz tam olarak anlaşılamamış olan nöropatidir. Trombosit morfoloji ve fonksiyonları bu konuyla ilgili olarak hala araştırılmaktadır. Bu çalışmada diyabetik nöropati ile ortalama trombosit hacmi arasındaki ilişkiyi incelemeyi planladık.GEREÇ VE YÖNTEMLER: Ortalama trombosit hacmi nöropatisi olmayan ve olan tip 2 diyabetik hastalarda ve sağlıklı kontrollerde araştırıldı ve karşılaştırıldı. Daha sonra diyabetik hastalarımızda ortalama trombosit hacmi ile hipertansiyon, hiperlipidemi, hemoglobin A1c ve vücut kitle indeksi arasında ilişki olup olmadığına baktık. BULGULAR: Ortalama trombosit hacmi nöropatisi olan diyabetik hastalarda en yüksek idi. Nöropatisi olan ve olmayan diyabetik hastalarda hipertansiyon, hiperlipidemi, hipertansiyon ile hiperlipidemi varlığı ortalama trombosit hacminde farklılık yaratmadı. Ayrıca gruplarımızda ortalama trombosit hacmi ile hemoglobin A1c ve vücut kitle indeksi arasında korelasyon yoktu.SONUÇ: Büyük trombositlerin diyabetik komplikasyonlarda özellikle nöropatide önemli bir rolü olabileceğini düşünüyoruz. Ayrıca diyabetiklerde hipertansiyon, hiperlipidemi, obezite, diyabetes kontrolünün ortalama trombosit hacmini ile ilişkili olmadığını düşünüyoruz

Anahtar Kelimeler

Nöropati, Tip 2 Diyabetes Mellitus, Ortalama trombosit hacmi

Kaynakça

)Kamath S, Blann AD, Lip GY. Platelet activation: assess- ment and quantification. Eur Heart J. 2001; 22: 1561-71.
)Colwell JA. Vascular thrombosis in type II diabetes melli- tus. Diabetes. 1993; 42: 8-11.
)Erbaş T, Ertaş M, Yücel A, Keskinaslan A, Senocak M; TURNEP Study. Prevalence of peripheral neuropathy and painful peripheral neuropathy in Turkish diabetic patients. J Clin Neurophysiol. 2011; 8: 51-5.
)Kodiatte TA, Manikyam UK, Rao SB et al. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians. 2012; : 5-9.
)Jindal S, Gupta S, Gupta R et al. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011; 16: 86-9.
)Demirtunç R, Duman D, Başar M, Bilgi M, Teomete M, Garip T. The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabetes Com- plications. 2009; 23: 89-94.
)Bavbek N, Kargılı A, Kaftan O, Karakurt F, Koşar A, Akçay A. Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: Are they markers of vas- cular disease and diabetic nephropathy? Clin Appl Thromb Hemost. 2007; 13: 391-7.
)Mustand JF, Packham MA. Platelets and diabetes mellitus. New England J Med. 1984; 311: 665-7.
)Hekimsoy Z, Payzin B, Örnek T, Kandoğan G. Mean plate- let volume in type 2 diabetic patients. J Diabetes Complica- tions. 2004; 18: 173-6.
)Vinocour PD. Platelet abnormalities in diabetes mellitus. Diabetes. 1992; 41: 26-31.
)Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwen- huis HK, Kehrel B. Large platelets circulate in an activated state in diabetes mallitus. Semin Thromb Haemost. 1991; 17: 8.
)Sharpe PC, Thrink T. Mean platelet volume in diabetes mellitus. Q J Med. 1993; 86: 739-42.
)Jones RL, Paradise C, Peterson CM. Platelet survival in patients with diabetes mellitus. Diabetes. 1981; 30: 486-9.
)Cagliero E, Porta M, Cousins S, Kohner EM. Increased mean platelet volume in diabetic retinopathy. Haemostasis. : 12: 293-9. )Dindar S, Cinemre H, Sengül E, Annakaya AN. Mean platelet volume is associated with glycemic control and reti- nopathy in patients with type 2 di- abetes mellitus. West Indian Med L. 2013; 62: 519-23.
)Betteridge D, Zahavi J. Jones NAG, Shine B, Kakar VV, Galton DJ. Platelet function in diabetes mellitus in relation- ship to complications, glycosylated hemoglobin and serum lipoproteins. Eur J Clin Invest. 1981; 11: 273-7.
)Zhong ZL, Han M, Chen S. Risk factors associated with retinal neovascularisation of diabetic retinopathy in type 2 diabetes mellitus. Int J Ophtalmol. 2011; 4: 182-5.
)Tuzcu AE, Arıca S, İlhan N et al. Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes. Graefes Arch Clin exp Ophtalmol. 2014; 252: 237-40.
)Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011; : 358-60.
)Ünübol M, Ayhan M, Güney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets. ; 23: 475-80. )Turgutalp K, Özhan O, Akbay E et al. Mean platelet vol- ume and related factors in patients at different stages of dia- betic nephropathy: A preliminary study. Appl Thromb He- most. 2014; 20: 190-5.
)Papanas N, Symonidis G, Maltezos E et al. Mean platelet volume with type 2 diabetes mellitus. Platelets. 2004; 15: 475-8.
)Shah B, Sha D, Xie D, Mohler ER, Berger JS. The relation- ship between diabetes, metabolic syndrome and platelet ac- tivity as measured by mean platelet volume. Diabetes Care. ; 35: 1074-8.
)Keskin S, Gürler M, Temeloğlu M, Çelebi A, Alicanoğlu R, Ekizoğlu I. Relation between mean platelet volume and risk factors for coronary heart disease. Turkiye Klinikleri J Med Sci. 2006; 26: 380-384.
)Zdrojewski Z, Lizakowski S, Raszeja-Specht A, Skibows- ka A, Rutkowski B. Influence of spontaneous thrombocyte aggregation on progression of glomerular disease. Nephron. )Yarlioglues M, Kaya MG, Ardic I et al. Relationship be- tween mean platelet volume levels and subclinical target or- gan damage in newly diagnosed hypertensive patients. Blood Pres. 2011; 20: 92-7.
)Bath PMW, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. ; 7: 431-6. )Martin JF, Bath PMW, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991; 338: 11.
)Pizzulli L, Yang A, Martin JF, Luderitz B. Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J. 1998; 19: 80-4.
)Hendra TJ, Oswald GA, Yudkin YS. Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes Research and Clini- cal Practice. 1988; 5: 63-9.
) Lalouschek W, Lang W, Müler M; Vienna Stroke study Group. Current strategies of secondary prevention after a cerebrovascular event: the Vienna stroke registry. Stroke. ; 32: 2860-6.
)Bennett PH. The diagnosis of diabetes: new international classification and diagnostic criteria. Annu Rev Med. 1983; : 295-309.
)Mancia G, De Backer G Dominiczak A et al. Management of arterial hypertension of the European Society of Hyper- tension, European Society of Cardiology, 2007 guidelines for the management of arterial hypertension. J Hypertens. 2007; : 1105-87.
)National Cholesterol Education Program. Detection, evaluation and treatment of high blood cholesterol in adults. Circulation. 2002: 106: 3145-421.
)Lauritzen T, Frost-Larsen K, Larsen HW, Deckert T. Two year experience with continous subcutaneous insulin in- fusiıon ln relation to retinopathy and neuropathy. Diabetes. ; 34: 74-9. )Satman I, Yilmaz T, Sengül A et al. Population based study of diabetes and risk characteristics in Turkey: results of the turkish diabetes epidemiology study (TURDEP). Diabetes Care. 2002; 25: 1551-6.
)Satman I, Omer B, Tutuncu Y et al. Twelve year trends in the prevaence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol. 2103; 28: 169-80.
)Zuberi BF, Akhtar N, Afsar S. Comparison of mean plate- let volume in patients with diabetes mellitus, impaired fasting glucose and non- diabetic subjects. Singapore Med J. 2008; : 114-6.
)Coban E, Bostan F, Özdoğan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets. 2006; 17: 9.
)Shimodaire M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and fasting plasma glucose levels in prediabetic and normo- glycemic individuals. Cardiovasc Diabetol. 2013; 12: 12-14.
)Shimodaire M, Niwa T, Nakajima K, Kobayashi M, Hanyu N, Nakayama T. Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normo- glycemic and prediabetic Japanese subjects. J Diabetes Inves- tig. 2014; 5: 66-71.
)Coban E, Kucuktağ S, Basyiğit S. Platelet activation in subjects with impaired glucore tolerance. Platelets. 2007; 18: 4.
)Erikçi AA, Muhçu M, Dündar O, Öztürk A. Could mean platelet volume be a predictive marker for gestational diabe- tes. Hematology. 2008; 13: 46-8.
)Iyıdır OT, Degertekin CK, Yılmaz BA, Toruner FB, Akturk M, Aslan M. Elevated mean platelet volume is associated with gestational diabetes. Gynecol Endocrinol. 2014; 30: 640-3.
)Keating FK, Sobel BE, Schneider DJ. Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus. Am J Cardiol. 2003; 92: 1362-5.
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Toplam 78 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Bölüm	Araştırma makalesi
Yazarlar	Fatih Güngör Bu kişi benim Gül Gürsoy Bu kişi benim Aslı Araz Güngör Bu kişi benim Seyit Murat Bayram Bu kişi benim Eray Atalay Bu kişi benim Mehmet Serhat Bayhan Bu kişi benim
Yayımlanma Tarihi	1 Mart 2016
Yayımlandığı Sayı	Yıl 2016 Cilt: 49 Sayı: 1

Kaynak Göster

AMA	Güngör F, Gürsoy G, Güngör AA, Bayram SM, Atalay E, Bayhan MS. TİP 2 DİYABETES MELLİTUS HASTALARINDA ORTALAMA TROMBOSİT HACMİ İLE NÖROPATİ ARASINDAKİ İLİŞKİ. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. Mart 2016;49(1):10-19.

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