Öz
ACE2 receptors are reported to have an important role in myocardial injury in Covid-19. Direct myocardial toxic effect of virus, myocarditis, cytokine injury, microangiopathic injury related to virus infection may cause myocardial injury and eventually troponin levels increase. Those mechanisms are; unstable plaques in coronary arteries resulting in myocardial hypoxia, upregulation of ACE2 receptors in coronary arteries and cardiac tissue, direct toxic effect of virus towards myocytes, systemic inflammation, myocardial interstitial fibrosis, excessive immune response to interferon, increased cytokine release from helper T lymphocytes which lead to myocardial injury. In this reported case, clinical course was mild and outcome was good, patient was followed in ward and he did not need intensive care.
Anahtar Kelimeler
Kaynakça
- 1. Wang Y, Roever L, Tse G, Liu T. 2019-Novel Coronavirus-Related Acute Cardiac Injury Cannot Be Ignored. Curr Atheroscler Rep. 2020 May 7;22(3):14. doi: 10.1007/s11883-020-00842-y. Review
- 2. Bennett CE, Anavekar NS, Gulati R, Singh M, Kane GC, Sandoval Y et al. ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties. Mayo Clin Proc. 2020 Apr 11. pii: S0025-6196(20)30366-9. doi: 10.1016/j.mayocp.2020.04.005.
- 3. https://www.uptodate.com/contents/coronavirus-disease-2019-covid-19-myocardial-injury, Accessed 28th May, 2020.
- 4. https://covid19bilgi.saglik.gov.tr/depo/rehberler/COVID-19_Rehberi.pdf, Accessed 28th May, 2020.
- 5. Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, Cani DS, Cerini M, Farina D, Gavazzi E, Maroldi R, Adamo M, Ammirati E, Sinagra G, Lombardi CM, Metra M. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol 2020. https://doi.org/10.1001/jamacardio.2020.1096
- 6. Chen C, Zhou Y, Wang DW. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz 2020. https://doi.org/10.1007
- 7. Babapoor-Farrokhran S, Gill D, Walker J, Rasekhi RT, Bozorgnia B, Amanullah A. Myocardial Injury and COVID-19: Possible Mechanisms. Life Sci. 2020 Apr 28;253:117723. doi: 10.1016/j.lfs.2020.117723.
- 8. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological fndings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020. https://doi.org/10.1016/S2213-2600(20)30076-X.
- 9. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol 2020. https://doi.org/10.1001/jamacardio.2020.1286
- 10. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506
- 11. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–13.
- 12. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020. https://doi.org/10.1001/jama.2020.1585
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2020 |
| Gönderilme Tarihi | 28 Mayıs 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 53 Sayı: 2 |