Effect of Respiratory Syncytial Virus Infection on Mean Platelet Volume in Newborns

Yıl 2021, Cilt: 54 Sayı: 1, 12 - 16, 27.04.2021

Hasan Akduman Seda Aydoğan Nurdan Dinlen Fettah Dilek Dilli Ahmet Öktem Ahmet Özyazıcı Duygu Bidev Ayşegül Zenciroğlu

https://doi.org/10.20492/aeahtd.771311

Öz

Objective: To determine the changes in the mean platelet volume (MPV) levels of the babies who were hospitalized in the neonatal intensive care unit (NICU) due to the respiratory syncytial virus (RSV) infection. It was also aimed to assess whether these changes were related to the severity of the disease, length of hospital stay, and Silverman Anderson respiratory severity score.
Material and methods: In this retrospective study, the patient group included the newborns at ≥34 gestational weeks who were diagnosed with RSV infection in the NICU. The control group consisted of healthy newborns without RSV infection. MPV values of the subjects were compared between the groupswith and without RSV.
Results: The MPV level in the group with RSV was significantly lower than the control group (p <0.05). The MPV levels did not correlate with the NICU length, duration of mechanical ventilation, the need for any respiratory support, and hemoglobin levels(p> 0.05).No statistically significant relationship was found between Silverman’s scores and MPV levels in the study patients (p <0.05).However, when we classified the respiratory score asmild (2-4 points), moderate (5-7 points), severe (8-10 points), a negative relationship between MPV levels and respiratory scores were found (p <0.05).
Conclusion: We found that infection with RSV in newborns was associated with a decrease in the MPV.Further studies are needed in order to evaluate the impact of RSV infection on MPV values.

Anahtar Kelimeler

Respiratory syncytial virus, mean platelet volume, Silverman Anderson score

Yenidoğanlarda Respiratuar Sinsityal Virüs Enfeksiyonunun Ortalama Trombosit Hacmi Üzerine Etkisi

Öz

Amaç: Respiratuar sinsityal virus enfeksiyonu (RSV) nedeniyle yenidoğan yoğun bakım ünitesine (YYBÜ) yatan bebeklerin ortalama trombosit hacmi (MPV) düzeylerinde meydana gelen değişiklikleri belirlemek. Ayrıca bu değişikliklerin hastalığın şiddeti, hastanede kalış süresi ve Silverman Anderson solunum şiddeti skoru (SAS) ile ilişkili olup olmadığının değerlendirilmesi amaçlandı.
Materyal ve metodlar: Bu retrospektif çalışmada, hasta grubu YYBÜ'de RSV enfeksiyonu tanısı almış ≥34 gebelik haftasında doğan yenidoğan bebeklerden, kontrol grubu ise RSV enfeksiyonu olmayan sağlıklı yenidoğanlardan oluşuyordu. Olguların MPV değerleri RSV olan ve olmayan gruplar arasında karşılaştırıldı.
Bulgular: RSV olan gruptaki MPV düzeyi kontrol grubundan anlamlı olarak düşüktü (p <0.05). MPV düzeyleri, YYBÜde yatış süresi, mekanik ventilasyonda kalma süresi, herhangi bir solunum destek ihtiyacı ve hemoglobin düzeyleri ile ilişkili değildi (p> 0.05). Çalışma hastalarında SAS’ları ile MPV düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunmadı (p <0.05). Ancak solunum skorunu hafif (2-4 puan), orta (5-7 puan), şiddetli (8-10 puan) olarak sınıflandırdığımızda MPV düzeyleri ile solunum skorları arasında negatif ilişki saptandı (p <0.05).
Sonuç: Yenidoğanlarda RSV ile enfeksiyonun MPV'de bir azalma ile ilişkili olduğunu bulduk. RSV enfeksiyonunun MPV değerleri üzerindeki etkisini değerlendirmek için daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

Respiratuar sinsityal virüs, ortalama trombosit hacmi, Silverman Anderson skoru

Kaynakça

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