Suboptimal ovaryen yanıtta POSEIDON grup 1b ve 2b hastaların in vitro fertilizasyon sonuçları: Retrospektif analiz

Yıl 2023, Cilt: 56 Sayı: 2, 121 - 124, 30.09.2023

Müge Keskin Ahmet Atik Gamze Sinem Çağlar

https://doi.org/10.20492/aeahtd.1310204

Öz

Amaç: Hastalar, over rezerv testlerinde yola çıkarak; ovaryen stimülasyona (OS) zayıf, normal veya aşırı yanıt vermesi beklenenler olarak sınıflandırılır. Hastaları zayıf, normal ve aşırı yanıt verenler olarak üç kategoriye ayırmanın, yeterliliği sorgulanmaktadır ve suboptimal (beklenenin altında) yanıt verenlerin ayrı bir grup olarak dahil edilmesi önerilmektedir. Suboptimal yanıt verenler, OS sonrası 4’ten az oosit toplanan zayıf ve 10-15 arası oosit toplanan normal yanıt verenler arasındaki gruptur. Bu hastalardan 4-9 arası oosit toplanır ve POSEIDON sınıflamasına göre grup 1b-2b’yi (PG 1b-2b) oluşturur. Çalışmamızın amacı PG 1b-2b hastaların IVF (in vitro fertilzasyon) sonuçlarını normal yanıt verenlerle karşılaştırmaktır.
Gereç Yöntem: Bu çalışmada, bir IVF kliniğinde retrospektif data analizi yapıldı. Normal yanıt verenlerle (yeterli over rezervine sahip ve ≥9 oosit toplanan) ve PG 1b-2b kadınların (yeterli over rezervine sahip standart OS sonrası 4-9 arası oosit toplanan, sırasıyla <35 yaş ve ≥35 yaş) embriyo transferi (ET) başına canlı doğum ve gebelik oranları karşılaştırıldı.
Bulgular: PG 1b ve 2b ile normal yanıt verenler arasında gebelik ve düşük oranlar benzerdi. Canlı doğum oranları, normal yanıt verenlerde PG 1b-2b hastalara göre anlamlı olarak yüksekti (%29.8 vs %6.3, p:0.02).
Sonuç: Bu çalışmada normal yanıt veren kadınlarda, PG 1b-2b grubuna kıyasla artmış canlı doğum oranları gösterildi. Normal yanıt verenlerin gebelik sayısı, PG 1b-2b’dekinin yaklaşık dört katı olmasına rağmen iki grup arasında gebelik oranları açısından anlamlı fark gösterilememesi gruplardaki hasta sayısının az olmasıyla açıklanabilir. PG 1b ve 2b grubundaki azalmış canlı doğum oranları yeni tanımlanan bu hasta grubunda prognozu iyileştirecek ek yaklaşımlar gerektiğini düşündürmektedir.
Anahtar Kelimeler: Ovulasyon indüksiyonu; in vitro fertilizasyon, gebelik oranı

Anahtar Kelimeler

gebelik oranı, ovulasyon indüksiyonu, in vitro fertilizasyon

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

In vitro fertilization outcomes of POSEIDON group 1b and 2b patients with suboptimal ovarian response: Retrospective analysis

Öz

Objective: Based on the ovarian reserve tests, patients’ expected response to ovarian stimulation (OS) can be classified into three groups as poor, normal and high response. The adequacy of dividing patients into three categories as poor (PR), normo (NR) and high responders (HR) is questioned and including suboptimal responders (SR) as a separate group is recommended. SRs are between PRs with less than 4 oocytes retrieved and NRs with 10-15 oocytes retrieved after OS. SRs wih 4-9 oocytes retrieved are classified as group 1b-2b (PG 1b-2b) according to POSEIDON classification. The aim of our study is to compare IVF (in vitro fertilization) outcomes of PG 1b-2b patients with NRs.
Material and Method: This was a retrospective data analysis of patients presenting at an IVF clinic. NRs were compared to and PG 1b-2b patients (4-9 oocytes retrieved after OS with adequate ovarian reserve, <35 years and ≥35 years, respectively) in terms of pregnancy rates and live birth rates (LBR).
Results: Pregnancy and miscarriage rates were comparable between PG 1b-2b PRs and NRs. LBRs were significantly higher in NRs compared to PG 1b-2b PRs (29.8% vs 6.3%, p:0.02).
Conclusion: Higher LBRs were observed in NRs compared to the PG 1b-2b PRs. Despite the four times higher pregnancy rates in NRs, lack of a significant difference in pregnancy rates between groups may be due to the small number of patients. Lower LBRs in PG 1b -2b PRs suggest that new treatment options are required to improve prognosis in SRs.
Keywords: Ovulation induction; in vitro fertilization, pregnancy rate

Anahtar Kelimeler

pregnancy rate,, in vitro fertilization,, ovulation induction

Proje Numarası

yok

Kaynakça

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