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COVID-19 PANDEMİSİ SIRASINDA ÜÇÜNCÜ BASAMAK REFERANS BİR YENİDOĞAN YOĞUN BAKIM ÜNİTESİNDE ÇOK PRETERM DOĞUM ORANLARI

Yıl 2025, Cilt: 58 Sayı: 2, 76 - 80, 29.08.2025
https://doi.org/10.20492/aeahtd.1378815

Öz

Amaç: Viral hastalıkların gebelik ve fetüs üzerine önemli etkilerinden birinin preterm doğum olduğu bilinmektedir. Amacımız COVID 19 pandemisinin Türkiye’de yoğun bir üçüncü basamak referans yenidoğan yoğun bakım ünitesine <32 hafta preterm bebek yatış sıklığı üzerine etkisinin araştırılmasıdır.
Gereç ve Yöntem: Yenidoğan Yoğun Bakım Ünitesine (YYBÜ) pandemi öncesi Eylül 2019-Şubat 2020 ve pandemi sonrası yılın aynı dönemi (Eylül 2020-Şubat 2021) çok preterm (<32 hafta) bebek yatış oranı retrospektif olarak karşılaştırıldı.
Maternal/ neonatal özellikler ve perinatal risk faktörleri hasta kayıtlarından elde edildi.
Bulgular: Pandemi öncesi 6 aylık dönemde yenidoğan yoğun bakım ünitesine toplam 1687 bebek yatışı olduğu ve 266’sının (%15.7) <32 hafta preterm olduğu görüldü. Pandemi sonrası dönemde ise toplam yatış sayısı 1648, preterm yatış sayısı 230 (%13.9) idi. Yatış sıklığında yaklaşık %2’lik düşüşün istatiksel olarak anlamlı olmadığı görüldü. Her iki dönemde gestasyon haftası (28± 2,7 ve 29± 2.8 hafta), doğum ağırlığı (1370±531 ve 1327±517 g) , ve diğer temel maternal ve neonatal özellikler benzerdi (p>0.01).
Sonuç: Pandemi ve getirmiş olduğu kısıtlamalar gebelik sonuçlarını; günlük aktivitelerde değişme, sosyal ve ekonomik etkiler, sağlık hizmetlerinden faydalanma gibi endirekt mekanizmalarla etkilemiş olabilir. Kısa dönemde ve kısıtlı bir kohort değerlendirildiğinde preterm yatış sayısı azalmış gibi görünse de bu bulguların ulusal veriler ile desteklenmesi gerekir.

Kaynakça

  • 1. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3-12.
  • 2. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7(1):e37-e46.
  • 3. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow DL, Biggerstaff MS, et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet. 2009;374(9688):451-458.
  • 4. Rasmussen SA, Jamieson DJ, Uyeki TM. Effects of influenza on pregnant women and infants. Am J Obstet Gynecol. 2012;207(3 Suppl):S3-S8.
  • 5. Fell DB, Platt RW, Basso O, Wilson K, Kaufman JS, Buckeridge DL, et al. The Relationship Between 2009 Pandemic H1N1 Influenza During Pregnancy and Preterm Birth: A Population-based Cohort Study. Epidemiology. 2018;29(1):107-116.
  • 6. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-564.
  • 7. Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol. 2020 May;55(5):586-592.
  • 8. Browne PC, Linfert JB, Perez-Jorge E. Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection. Am J Perinatol. 2020 Jun;37(8):866-868.
  • 9. Leibovitch L, Reichman B, Mimouni F, Zaslavsky-Paltiel I, Lerner- Geva L, Wasserteil N, et al. Preterm Singleton Birth Rate during the COVID-19 Lockdown: A Population-Based Study. Am J Perinatol. 2022 Jul;39(9):1020-1026.
  • 10. Sahin D, Tanacan A, Erol SA, Yucel Yetiskin FD, Besimoglu B, Ozden Tokalioglu E, et al. Management of pregnant women with COVID-19: A tertiary pandemic center experience on 1416 cases. J Med Virol. 2022 Mar;94(3):1074-1084.
  • 11. Turkish Ministry of Health, General Directorate of Public Health, COVİD-19 (SARS-CoV-2 infection) Guideline, Scientific Committee Report. https://covid19bilgi.saglik.gov.tr/depo/rehberler/ COVID-19_Rehberi.pdf?type=file.
  • 12. Hedermann G, Hedley PL, Bækvad-Hansen M, Hjalgrim H, Rostgaard K, Poorisrisak P, et al. Danish premature birth rates during the COVID-19 lockdown. Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):93-95.
  • 13. Philip RK, Purtill H, Reidy E, Daly M, Imcha M, McGrath D, et al. Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing analysis of data from the prior two decades. BMJ Glob Health. 2020 Sep;5(9):e003075.
  • 14. Berghella V, Boelig R, Roman A, Burd J, Anderson K. Decreased incidence of preterm birth during coronavirus disease 2019 pandemic. Am J Obstet Gynecol MFM. 2020 Nov;2(4):100258.
  • 15. Bian Z, Qu X, Ying H, Liu X. Are COVID-19 mitigation measures reducing preterm birth rate in China? BMJ Glob Health. 2021 Aug;6(8):e006359.
  • 16. Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P, Magee L. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic. JAMA. 2020 Jul 10;324(7):705–6.
  • 17. De Curtis M, Villani L, Polo A. Increase of stillbirth and decrease of late preterm infants during the COVID-19 pandemic lockdown. Arch Dis Child Fetal Neonatal Ed. 2021 Jul;106(4):456.
  • 18. Lin TT, Zhang C, Chen L, Jin L, Lin XH, Pan JX, et al. COVID-19 Lockdown Increased the Risk of Preterm Birth. Front Med (Lausanne). 2021 Sep 27;8:705943.
  • 19. Özkan H, Erdeve Ö, Kutman HGK. Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment. Turk Pediatri Ars. 2018;53(Suppl 1):S45-S54.
  • 20. Erdeve O, Yurttutan S, Altug N, Ozdemir R, Gokmen T, Dilmen, U, et al. Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2012;97(4):F279-F283.
  • 21. Kliegman RM, Walsh MC. Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness. Curr Probl Pediatr. 1987;17(4):213-288.
  • 22. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163(7):1723-1729.
  • 23. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92(4):529-534. 80
  • 24. Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr. 2016;28(2):135-140.
  • 25. Pasternak B, Neovius M, Söderling J, Ahlberg M, Norman M, Ludvigsson JF, et al. Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study. Ann Intern Med. 2021 Jun;174(6):873-875.
  • 26. Main EK, Chang SC, Carpenter AM, Wise PH, Stevenson DK, Shaw GM, et al. Singleton preterm birth rates for racial and ethnic groups during the coronavirus disease 2019 pandemic in California. Am J Obstet Gynecol. 2021 Feb;224(2):239-241.
  • 27. Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams D, Lorch SA, et al. Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020. JAMA. 2021 Jan 5;325(1):87-89.
  • 28. Simon E, Cottenet J, Mariet AS, Bechraoui-Quantin S, Rozenberg P, Gouyon JB, et al. Impact of the COVID-19 pandemic on preterm birth and stillbirth: a nationwide, population-based retrospective cohort study. Am J Obstet Gynecol. 2021 Sep;225(3):347- 348.
  • 29. Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE, Bruckner T. Changes in preterm birth and caesarean deliveries in the United States during the SARS-CoV-2 pandemic. Paediatr Perinat Epidemiol. 2022 Jul;36(4):485-489.
  • 30. Alshaikh B, Cheung PY, Soliman N, Brundler MA, Yusuf K. Impact of Lockdown Measures during COVID-19 Pandemic on Pregnancy and Preterm Birth. Am J Perinatol. 2022 Feb;39(3):329-336.
  • 31. Klumper J, Kazemier BM, Been JV, Bloemenkamp KWM, de Boer MA, Erwich JJHM, et al. Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study. BMC Pregnancy Childbirth. 2021 Nov 12;21(1):767.
  • 32. Hekimoğlu B, Aktürk Acar F. Effects of COVID-19 pandemic period on neonatal mortality and morbidity. Pediatr Neonatol. 2022;63(1):78-83.
  • 33. Indrio F, Salatto A, Amato O, Bartoli F, Capasso L, Corvaglia L, et al. COVID-19 pandemic in the neonatal intensive care unit: any effect on late-onset sepsis and necrotizing enterocolitis? Eur J Pediatr. 2022;181(2):853-857.
  • 34. Palleri E, Svenningsson A, Markasz L, Engstrand Lilja H. The Incidence of Necrotizing Enterocolitis and Late-Onset Sepsis during the COVID-19 Pandemic in Sweden: A Population-Based Cohort Study. Neonatology. 2024;121(3):336-341.

VERY PRETERM BIRTH RATES AT A REFERRAL TERTIARY NEONATAL INTENSIVE CARE UNIT DURING COVID-19 PANDEMIC

Yıl 2025, Cilt: 58 Sayı: 2, 76 - 80, 29.08.2025
https://doi.org/10.20492/aeahtd.1378815

Öz

Aim: It is known that one of the important effects of viral diseases on pregnancy and fetus is preterm delivery. We aim to evaluate the impact of the COVID-19 pandemic on the frequency of very preterm (<32 weeks gestational age) infant admission at a referral tertiary neonatal intensive care unit in Turkey.
Material and Method: Very preterm infant admission rates to Neonatal Intensive Care Unit from September 2019-February 2020 before the pandemic and the same period of the year after the pandemic (September 2020-February 2021) were retrospectively compared. Maternal/ neonatal characteristics and perinatal risk factors were collected from patient records.
Results: A total of 1687 infants were admitted to the NICU during the 6 months before the pandemic, 266 (15.7%) of them were very preterm infants. The number of total admissions was 1648 and 230 (13.9%) of them were very preterm during the pandemic. About a 2% decrease in admission rates was not statistically significant. Mean gestational age (28± 2,7 and 29± 2.8 weeks), mean birth weight (1370± 531 and 1327± 517 g), and other basic maternal and neonatal characteristics were similar (p>0.01).
Conclusion: Pandemic and its restrictions may have affected to outcomes of pregnancy by indirect mechanisms such as changes in daily activities, social and economic effects, benefiting of health services. Although the number of preterm admission between the two periods seems to have no difference considering a limited cohort and short-term evaluation, these results should be supported by national data.

Kaynakça

  • 1. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3-12.
  • 2. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7(1):e37-e46.
  • 3. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow DL, Biggerstaff MS, et al. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet. 2009;374(9688):451-458.
  • 4. Rasmussen SA, Jamieson DJ, Uyeki TM. Effects of influenza on pregnant women and infants. Am J Obstet Gynecol. 2012;207(3 Suppl):S3-S8.
  • 5. Fell DB, Platt RW, Basso O, Wilson K, Kaufman JS, Buckeridge DL, et al. The Relationship Between 2009 Pandemic H1N1 Influenza During Pregnancy and Preterm Birth: A Population-based Cohort Study. Epidemiology. 2018;29(1):107-116.
  • 6. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-564.
  • 7. Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol. 2020 May;55(5):586-592.
  • 8. Browne PC, Linfert JB, Perez-Jorge E. Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection. Am J Perinatol. 2020 Jun;37(8):866-868.
  • 9. Leibovitch L, Reichman B, Mimouni F, Zaslavsky-Paltiel I, Lerner- Geva L, Wasserteil N, et al. Preterm Singleton Birth Rate during the COVID-19 Lockdown: A Population-Based Study. Am J Perinatol. 2022 Jul;39(9):1020-1026.
  • 10. Sahin D, Tanacan A, Erol SA, Yucel Yetiskin FD, Besimoglu B, Ozden Tokalioglu E, et al. Management of pregnant women with COVID-19: A tertiary pandemic center experience on 1416 cases. J Med Virol. 2022 Mar;94(3):1074-1084.
  • 11. Turkish Ministry of Health, General Directorate of Public Health, COVİD-19 (SARS-CoV-2 infection) Guideline, Scientific Committee Report. https://covid19bilgi.saglik.gov.tr/depo/rehberler/ COVID-19_Rehberi.pdf?type=file.
  • 12. Hedermann G, Hedley PL, Bækvad-Hansen M, Hjalgrim H, Rostgaard K, Poorisrisak P, et al. Danish premature birth rates during the COVID-19 lockdown. Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):93-95.
  • 13. Philip RK, Purtill H, Reidy E, Daly M, Imcha M, McGrath D, et al. Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing analysis of data from the prior two decades. BMJ Glob Health. 2020 Sep;5(9):e003075.
  • 14. Berghella V, Boelig R, Roman A, Burd J, Anderson K. Decreased incidence of preterm birth during coronavirus disease 2019 pandemic. Am J Obstet Gynecol MFM. 2020 Nov;2(4):100258.
  • 15. Bian Z, Qu X, Ying H, Liu X. Are COVID-19 mitigation measures reducing preterm birth rate in China? BMJ Glob Health. 2021 Aug;6(8):e006359.
  • 16. Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P, Magee L. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic. JAMA. 2020 Jul 10;324(7):705–6.
  • 17. De Curtis M, Villani L, Polo A. Increase of stillbirth and decrease of late preterm infants during the COVID-19 pandemic lockdown. Arch Dis Child Fetal Neonatal Ed. 2021 Jul;106(4):456.
  • 18. Lin TT, Zhang C, Chen L, Jin L, Lin XH, Pan JX, et al. COVID-19 Lockdown Increased the Risk of Preterm Birth. Front Med (Lausanne). 2021 Sep 27;8:705943.
  • 19. Özkan H, Erdeve Ö, Kutman HGK. Turkish Neonatal Society guideline on the management of respiratory distress syndrome and surfactant treatment. Turk Pediatri Ars. 2018;53(Suppl 1):S45-S54.
  • 20. Erdeve O, Yurttutan S, Altug N, Ozdemir R, Gokmen T, Dilmen, U, et al. Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 2012;97(4):F279-F283.
  • 21. Kliegman RM, Walsh MC. Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness. Curr Probl Pediatr. 1987;17(4):213-288.
  • 22. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163(7):1723-1729.
  • 23. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92(4):529-534. 80
  • 24. Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr. 2016;28(2):135-140.
  • 25. Pasternak B, Neovius M, Söderling J, Ahlberg M, Norman M, Ludvigsson JF, et al. Preterm Birth and Stillbirth During the COVID-19 Pandemic in Sweden: A Nationwide Cohort Study. Ann Intern Med. 2021 Jun;174(6):873-875.
  • 26. Main EK, Chang SC, Carpenter AM, Wise PH, Stevenson DK, Shaw GM, et al. Singleton preterm birth rates for racial and ethnic groups during the coronavirus disease 2019 pandemic in California. Am J Obstet Gynecol. 2021 Feb;224(2):239-241.
  • 27. Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams D, Lorch SA, et al. Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020. JAMA. 2021 Jan 5;325(1):87-89.
  • 28. Simon E, Cottenet J, Mariet AS, Bechraoui-Quantin S, Rozenberg P, Gouyon JB, et al. Impact of the COVID-19 pandemic on preterm birth and stillbirth: a nationwide, population-based retrospective cohort study. Am J Obstet Gynecol. 2021 Sep;225(3):347- 348.
  • 29. Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE, Bruckner T. Changes in preterm birth and caesarean deliveries in the United States during the SARS-CoV-2 pandemic. Paediatr Perinat Epidemiol. 2022 Jul;36(4):485-489.
  • 30. Alshaikh B, Cheung PY, Soliman N, Brundler MA, Yusuf K. Impact of Lockdown Measures during COVID-19 Pandemic on Pregnancy and Preterm Birth. Am J Perinatol. 2022 Feb;39(3):329-336.
  • 31. Klumper J, Kazemier BM, Been JV, Bloemenkamp KWM, de Boer MA, Erwich JJHM, et al. Association between COVID-19 lockdown measures and the incidence of iatrogenic versus spontaneous very preterm births in the Netherlands: a retrospective study. BMC Pregnancy Childbirth. 2021 Nov 12;21(1):767.
  • 32. Hekimoğlu B, Aktürk Acar F. Effects of COVID-19 pandemic period on neonatal mortality and morbidity. Pediatr Neonatol. 2022;63(1):78-83.
  • 33. Indrio F, Salatto A, Amato O, Bartoli F, Capasso L, Corvaglia L, et al. COVID-19 pandemic in the neonatal intensive care unit: any effect on late-onset sepsis and necrotizing enterocolitis? Eur J Pediatr. 2022;181(2):853-857.
  • 34. Palleri E, Svenningsson A, Markasz L, Engstrand Lilja H. The Incidence of Necrotizing Enterocolitis and Late-Onset Sepsis during the COVID-19 Pandemic in Sweden: A Population-Based Cohort Study. Neonatology. 2024;121(3):336-341.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yenidoğan
Bölüm Araştırma Makalesi
Yazarlar

Gökçe Çıplak 0000-0002-5853-3665

Nazlı Tekeli 0000-0003-3693-1985

Eda Ozden Tokalıoglu 0000-0003-4901-0544

Dilek Sahin 0000-0001-8567-9048

Cüneyt Tayman 0000-0002-9970-0714

Hayriye Gözde Kanmaz Kutman 0000-0002-3177-9411

Yayımlanma Tarihi 29 Ağustos 2025
Gönderilme Tarihi 20 Ekim 2023
Kabul Tarihi 3 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 58 Sayı: 2

Kaynak Göster

AMA Çıplak G, Tekeli N, Ozden Tokalıoglu E, Sahin D, Tayman C, Kanmaz Kutman HG. VERY PRETERM BIRTH RATES AT A REFERRAL TERTIARY NEONATAL INTENSIVE CARE UNIT DURING COVID-19 PANDEMIC. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. Ağustos 2025;58(2):76-80. doi:10.20492/aeahtd.1378815