COVID-19 PANDEMİSİ SIRASINDA ÜÇÜNCÜ BASAMAK REFERANS BİR YENİDOĞAN YOĞUN BAKIM ÜNİTESİNDE ÇOK PRETERM DOĞUM ORANLARI
Yıl 2025,
Cilt: 58 Sayı: 2, 76 - 80, 29.08.2025
Gökçe Çıplak
,
Nazlı Tekeli
,
Eda Ozden Tokalıoglu
,
Dilek Sahin
,
Cüneyt Tayman
,
Hayriye Gözde Kanmaz Kutman
Öz
Amaç: Viral hastalıkların gebelik ve fetüs üzerine önemli etkilerinden birinin preterm doğum olduğu bilinmektedir. Amacımız COVID 19 pandemisinin Türkiye’de yoğun bir üçüncü basamak referans yenidoğan yoğun bakım ünitesine <32 hafta preterm bebek yatış sıklığı üzerine etkisinin araştırılmasıdır.
Gereç ve Yöntem: Yenidoğan Yoğun Bakım Ünitesine (YYBÜ) pandemi öncesi Eylül 2019-Şubat 2020 ve pandemi sonrası yılın aynı dönemi (Eylül 2020-Şubat 2021) çok preterm (<32 hafta) bebek yatış oranı retrospektif olarak karşılaştırıldı.
Maternal/ neonatal özellikler ve perinatal risk faktörleri hasta kayıtlarından elde edildi.
Bulgular: Pandemi öncesi 6 aylık dönemde yenidoğan yoğun bakım ünitesine toplam 1687 bebek yatışı olduğu ve 266’sının (%15.7) <32 hafta preterm olduğu görüldü. Pandemi sonrası dönemde ise toplam yatış sayısı 1648, preterm yatış sayısı 230 (%13.9) idi. Yatış sıklığında yaklaşık %2’lik düşüşün istatiksel olarak anlamlı olmadığı görüldü. Her iki dönemde gestasyon haftası (28± 2,7 ve 29± 2.8 hafta), doğum ağırlığı (1370±531 ve 1327±517 g) , ve diğer temel maternal ve neonatal özellikler benzerdi (p>0.01).
Sonuç: Pandemi ve getirmiş olduğu kısıtlamalar gebelik sonuçlarını; günlük aktivitelerde değişme, sosyal ve ekonomik etkiler, sağlık hizmetlerinden faydalanma gibi endirekt mekanizmalarla etkilemiş olabilir. Kısa dönemde ve kısıtlı bir kohort değerlendirildiğinde preterm yatış sayısı azalmış gibi görünse de bu bulguların ulusal veriler ile desteklenmesi gerekir.
Kaynakça
-
1. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet
M, Lumbiganon P. The global epidemiology of preterm birth. Best
Pract Res Clin Obstet Gynaecol. 2018;52:3-12.
-
2. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold
M, Hogan D, et al. Global, regional, and national estimates of levels
of preterm birth in 2014: a systematic review and modelling analysis.
Lancet Glob Health. 2019;7(1):e37-e46.
-
3. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow
DL, Biggerstaff MS, et al. H1N1 2009 influenza virus infection
during pregnancy in the USA. Lancet. 2009;374(9688):451-458.
-
4. Rasmussen SA, Jamieson DJ, Uyeki TM. Effects of influenza on
pregnant women and infants. Am J Obstet Gynecol. 2012;207(3
Suppl):S3-S8.
-
5. Fell DB, Platt RW, Basso O, Wilson K, Kaufman JS, Buckeridge
DL, et al. The Relationship Between 2009 Pandemic H1N1 Influenza
During Pregnancy and Preterm Birth: A Population-based Cohort
Study. Epidemiology. 2018;29(1):107-116.
-
6. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features
and obstetric and neonatal outcomes of pregnant patients
with COVID-19 in Wuhan, China: a retrospective, single-centre,
descriptive study. Lancet Infect Dis. 2020;20(5):559-564.
-
7. Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in
pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol.
2020 May;55(5):586-592.
-
8. Browne PC, Linfert JB, Perez-Jorge E. Successful Treatment of
Preterm Labor in Association with Acute COVID-19 Infection. Am J
Perinatol. 2020 Jun;37(8):866-868.
-
9. Leibovitch L, Reichman B, Mimouni F, Zaslavsky-Paltiel I, Lerner-
Geva L, Wasserteil N, et al. Preterm Singleton Birth Rate during
the COVID-19 Lockdown: A Population-Based Study. Am J Perinatol.
2022 Jul;39(9):1020-1026.
-
10. Sahin D, Tanacan A, Erol SA, Yucel Yetiskin FD, Besimoglu B,
Ozden Tokalioglu E, et al. Management of pregnant women with
COVID-19: A tertiary pandemic center experience on 1416 cases. J
Med Virol. 2022 Mar;94(3):1074-1084.
-
11. Turkish Ministry of Health, General Directorate of Public Health,
COVİD-19 (SARS-CoV-2 infection) Guideline, Scientific Committee
Report. https://covid19bilgi.saglik.gov.tr/depo/rehberler/
COVID-19_Rehberi.pdf?type=file.
-
12. Hedermann G, Hedley PL, Bækvad-Hansen M, Hjalgrim H, Rostgaard
K, Poorisrisak P, et al. Danish premature birth rates during
the COVID-19 lockdown. Arch Dis Child Fetal Neonatal Ed. 2021
Jan;106(1):93-95.
-
13. Philip RK, Purtill H, Reidy E, Daly M, Imcha M, McGrath D, et
al. Unprecedented reduction in births of very low birthweight
(VLBW) and extremely low birthweight (ELBW) infants during the
COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing
analysis of data from the prior two decades. BMJ Glob Health.
2020 Sep;5(9):e003075.
-
14. Berghella V, Boelig R, Roman A, Burd J, Anderson K. Decreased
incidence of preterm birth during coronavirus disease 2019 pandemic.
Am J Obstet Gynecol MFM. 2020 Nov;2(4):100258.
-
15. Bian Z, Qu X, Ying H, Liu X. Are COVID-19 mitigation measures
reducing preterm birth rate in China? BMJ Glob Health. 2021
Aug;6(8):e006359.
-
16. Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P,
Magee L. Change in the Incidence of Stillbirth and Preterm Delivery
During the COVID-19 Pandemic. JAMA. 2020 Jul 10;324(7):705–6.
-
17. De Curtis M, Villani L, Polo A. Increase of stillbirth and decrease
of late preterm infants during the COVID-19 pandemic lockdown.
Arch Dis Child Fetal Neonatal Ed. 2021 Jul;106(4):456.
-
18. Lin TT, Zhang C, Chen L, Jin L, Lin XH, Pan JX, et al. COVID-19
Lockdown Increased the Risk of Preterm Birth. Front Med (Lausanne).
2021 Sep 27;8:705943.
-
19. Özkan H, Erdeve Ö, Kutman HGK. Turkish Neonatal Society
guideline on the management of respiratory distress syndrome and
surfactant treatment. Turk Pediatri Ars. 2018;53(Suppl 1):S45-S54.
-
20. Erdeve O, Yurttutan S, Altug N, Ozdemir R, Gokmen T, Dilmen, U,
et al. Oral versus intravenous ibuprofen for patent ductus arteriosus
closure: a randomised controlled trial in extremely low birthweight
infants. Arch Dis Child Fetal Neonatal Ed. 2012;97(4):F279-F283.
-
21. Kliegman RM, Walsh MC. Neonatal necrotizing enterocolitis:
pathogenesis, classification, and spectrum of illness. Curr Probl
Pediatr. 1987;17(4):213-288.
-
22. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir
Crit Care Med. 2001;163(7):1723-1729.
-
23. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and
evolution of subependymal and intraventricular hemorrhage: a
study of infants with birth weights less than 1,500 gm. J Pediatr.
1978;92(4):529-534.
80
-
24. Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr.
2016;28(2):135-140.
-
25. Pasternak B, Neovius M, Söderling J, Ahlberg M, Norman
M, Ludvigsson JF, et al. Preterm Birth and Stillbirth During the
COVID-19 Pandemic in Sweden: A Nationwide Cohort Study. Ann
Intern Med. 2021 Jun;174(6):873-875.
-
26. Main EK, Chang SC, Carpenter AM, Wise PH, Stevenson DK,
Shaw GM, et al. Singleton preterm birth rates for racial and ethnic
groups during the coronavirus disease 2019 pandemic in California.
Am J Obstet Gynecol. 2021 Feb;224(2):239-241.
-
27. Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams
D, Lorch SA, et al. Changes in Preterm Birth Phenotypes and
Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic,
March-June 2020. JAMA. 2021 Jan 5;325(1):87-89.
-
28. Simon E, Cottenet J, Mariet AS, Bechraoui-Quantin S, Rozenberg
P, Gouyon JB, et al. Impact of the COVID-19 pandemic on
preterm birth and stillbirth: a nationwide, population-based retrospective
cohort study. Am J Obstet Gynecol. 2021 Sep;225(3):347-
348.
-
29. Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE,
Bruckner T. Changes in preterm birth and caesarean deliveries in
the United States during the SARS-CoV-2 pandemic. Paediatr Perinat
Epidemiol. 2022 Jul;36(4):485-489.
-
30. Alshaikh B, Cheung PY, Soliman N, Brundler MA, Yusuf K. Impact
of Lockdown Measures during COVID-19 Pandemic on Pregnancy
and Preterm Birth. Am J Perinatol. 2022 Feb;39(3):329-336.
-
31. Klumper J, Kazemier BM, Been JV, Bloemenkamp KWM, de Boer
MA, Erwich JJHM, et al. Association between COVID-19 lockdown
measures and the incidence of iatrogenic versus spontaneous
very preterm births in the Netherlands: a retrospective study. BMC
Pregnancy Childbirth. 2021 Nov 12;21(1):767.
-
32. Hekimoğlu B, Aktürk Acar F. Effects of COVID-19 pandemic
period on neonatal mortality and morbidity. Pediatr Neonatol.
2022;63(1):78-83.
-
33. Indrio F, Salatto A, Amato O, Bartoli F, Capasso L, Corvaglia L,
et al. COVID-19 pandemic in the neonatal intensive care unit: any
effect on late-onset sepsis and necrotizing enterocolitis? Eur J Pediatr.
2022;181(2):853-857.
-
34. Palleri E, Svenningsson A, Markasz L, Engstrand Lilja H. The Incidence
of Necrotizing Enterocolitis and Late-Onset Sepsis during
the COVID-19 Pandemic in Sweden: A Population-Based Cohort
Study. Neonatology. 2024;121(3):336-341.
VERY PRETERM BIRTH RATES AT A REFERRAL TERTIARY NEONATAL INTENSIVE CARE UNIT DURING COVID-19 PANDEMIC
Yıl 2025,
Cilt: 58 Sayı: 2, 76 - 80, 29.08.2025
Gökçe Çıplak
,
Nazlı Tekeli
,
Eda Ozden Tokalıoglu
,
Dilek Sahin
,
Cüneyt Tayman
,
Hayriye Gözde Kanmaz Kutman
Öz
Aim: It is known that one of the important effects of viral diseases on pregnancy and fetus is preterm delivery. We aim to evaluate the impact of the COVID-19 pandemic on the frequency of very preterm (<32 weeks gestational age) infant admission at a referral tertiary neonatal intensive care unit in Turkey.
Material and Method: Very preterm infant admission rates to Neonatal Intensive Care Unit from September 2019-February 2020 before the pandemic and the same period of the year after the pandemic (September 2020-February 2021) were retrospectively compared. Maternal/ neonatal characteristics and perinatal risk factors were collected from patient records.
Results: A total of 1687 infants were admitted to the NICU during the 6 months before the pandemic, 266 (15.7%) of them were very preterm infants. The number of total admissions was 1648 and 230 (13.9%) of them were very preterm during the pandemic. About a 2% decrease in admission rates was not statistically significant. Mean gestational age (28± 2,7 and 29± 2.8 weeks), mean birth weight (1370± 531 and 1327± 517 g), and other basic maternal and neonatal characteristics were similar (p>0.01).
Conclusion: Pandemic and its restrictions may have affected to outcomes of pregnancy by indirect mechanisms such as changes in daily activities, social and economic effects, benefiting of health services. Although the number of preterm admission between the two periods seems to have no difference considering a limited cohort and short-term evaluation, these results should be supported by national data.
Kaynakça
-
1. Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet
M, Lumbiganon P. The global epidemiology of preterm birth. Best
Pract Res Clin Obstet Gynaecol. 2018;52:3-12.
-
2. Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold
M, Hogan D, et al. Global, regional, and national estimates of levels
of preterm birth in 2014: a systematic review and modelling analysis.
Lancet Glob Health. 2019;7(1):e37-e46.
-
3. Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow
DL, Biggerstaff MS, et al. H1N1 2009 influenza virus infection
during pregnancy in the USA. Lancet. 2009;374(9688):451-458.
-
4. Rasmussen SA, Jamieson DJ, Uyeki TM. Effects of influenza on
pregnant women and infants. Am J Obstet Gynecol. 2012;207(3
Suppl):S3-S8.
-
5. Fell DB, Platt RW, Basso O, Wilson K, Kaufman JS, Buckeridge
DL, et al. The Relationship Between 2009 Pandemic H1N1 Influenza
During Pregnancy and Preterm Birth: A Population-based Cohort
Study. Epidemiology. 2018;29(1):107-116.
-
6. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features
and obstetric and neonatal outcomes of pregnant patients
with COVID-19 in Wuhan, China: a retrospective, single-centre,
descriptive study. Lancet Infect Dis. 2020;20(5):559-564.
-
7. Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in
pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol.
2020 May;55(5):586-592.
-
8. Browne PC, Linfert JB, Perez-Jorge E. Successful Treatment of
Preterm Labor in Association with Acute COVID-19 Infection. Am J
Perinatol. 2020 Jun;37(8):866-868.
-
9. Leibovitch L, Reichman B, Mimouni F, Zaslavsky-Paltiel I, Lerner-
Geva L, Wasserteil N, et al. Preterm Singleton Birth Rate during
the COVID-19 Lockdown: A Population-Based Study. Am J Perinatol.
2022 Jul;39(9):1020-1026.
-
10. Sahin D, Tanacan A, Erol SA, Yucel Yetiskin FD, Besimoglu B,
Ozden Tokalioglu E, et al. Management of pregnant women with
COVID-19: A tertiary pandemic center experience on 1416 cases. J
Med Virol. 2022 Mar;94(3):1074-1084.
-
11. Turkish Ministry of Health, General Directorate of Public Health,
COVİD-19 (SARS-CoV-2 infection) Guideline, Scientific Committee
Report. https://covid19bilgi.saglik.gov.tr/depo/rehberler/
COVID-19_Rehberi.pdf?type=file.
-
12. Hedermann G, Hedley PL, Bækvad-Hansen M, Hjalgrim H, Rostgaard
K, Poorisrisak P, et al. Danish premature birth rates during
the COVID-19 lockdown. Arch Dis Child Fetal Neonatal Ed. 2021
Jan;106(1):93-95.
-
13. Philip RK, Purtill H, Reidy E, Daly M, Imcha M, McGrath D, et
al. Unprecedented reduction in births of very low birthweight
(VLBW) and extremely low birthweight (ELBW) infants during the
COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing
analysis of data from the prior two decades. BMJ Glob Health.
2020 Sep;5(9):e003075.
-
14. Berghella V, Boelig R, Roman A, Burd J, Anderson K. Decreased
incidence of preterm birth during coronavirus disease 2019 pandemic.
Am J Obstet Gynecol MFM. 2020 Nov;2(4):100258.
-
15. Bian Z, Qu X, Ying H, Liu X. Are COVID-19 mitigation measures
reducing preterm birth rate in China? BMJ Glob Health. 2021
Aug;6(8):e006359.
-
16. Khalil A, von Dadelszen P, Draycott T, Ugwumadu A, O’Brien P,
Magee L. Change in the Incidence of Stillbirth and Preterm Delivery
During the COVID-19 Pandemic. JAMA. 2020 Jul 10;324(7):705–6.
-
17. De Curtis M, Villani L, Polo A. Increase of stillbirth and decrease
of late preterm infants during the COVID-19 pandemic lockdown.
Arch Dis Child Fetal Neonatal Ed. 2021 Jul;106(4):456.
-
18. Lin TT, Zhang C, Chen L, Jin L, Lin XH, Pan JX, et al. COVID-19
Lockdown Increased the Risk of Preterm Birth. Front Med (Lausanne).
2021 Sep 27;8:705943.
-
19. Özkan H, Erdeve Ö, Kutman HGK. Turkish Neonatal Society
guideline on the management of respiratory distress syndrome and
surfactant treatment. Turk Pediatri Ars. 2018;53(Suppl 1):S45-S54.
-
20. Erdeve O, Yurttutan S, Altug N, Ozdemir R, Gokmen T, Dilmen, U,
et al. Oral versus intravenous ibuprofen for patent ductus arteriosus
closure: a randomised controlled trial in extremely low birthweight
infants. Arch Dis Child Fetal Neonatal Ed. 2012;97(4):F279-F283.
-
21. Kliegman RM, Walsh MC. Neonatal necrotizing enterocolitis:
pathogenesis, classification, and spectrum of illness. Curr Probl
Pediatr. 1987;17(4):213-288.
-
22. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir
Crit Care Med. 2001;163(7):1723-1729.
-
23. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and
evolution of subependymal and intraventricular hemorrhage: a
study of infants with birth weights less than 1,500 gm. J Pediatr.
1978;92(4):529-534.
80
-
24. Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr.
2016;28(2):135-140.
-
25. Pasternak B, Neovius M, Söderling J, Ahlberg M, Norman
M, Ludvigsson JF, et al. Preterm Birth and Stillbirth During the
COVID-19 Pandemic in Sweden: A Nationwide Cohort Study. Ann
Intern Med. 2021 Jun;174(6):873-875.
-
26. Main EK, Chang SC, Carpenter AM, Wise PH, Stevenson DK,
Shaw GM, et al. Singleton preterm birth rates for racial and ethnic
groups during the coronavirus disease 2019 pandemic in California.
Am J Obstet Gynecol. 2021 Feb;224(2):239-241.
-
27. Handley SC, Mullin AM, Elovitz MA, Gerson KD, Montoya-Williams
D, Lorch SA, et al. Changes in Preterm Birth Phenotypes and
Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic,
March-June 2020. JAMA. 2021 Jan 5;325(1):87-89.
-
28. Simon E, Cottenet J, Mariet AS, Bechraoui-Quantin S, Rozenberg
P, Gouyon JB, et al. Impact of the COVID-19 pandemic on
preterm birth and stillbirth: a nationwide, population-based retrospective
cohort study. Am J Obstet Gynecol. 2021 Sep;225(3):347-
348.
-
29. Gemmill A, Casey JA, Catalano R, Karasek D, Margerison CE,
Bruckner T. Changes in preterm birth and caesarean deliveries in
the United States during the SARS-CoV-2 pandemic. Paediatr Perinat
Epidemiol. 2022 Jul;36(4):485-489.
-
30. Alshaikh B, Cheung PY, Soliman N, Brundler MA, Yusuf K. Impact
of Lockdown Measures during COVID-19 Pandemic on Pregnancy
and Preterm Birth. Am J Perinatol. 2022 Feb;39(3):329-336.
-
31. Klumper J, Kazemier BM, Been JV, Bloemenkamp KWM, de Boer
MA, Erwich JJHM, et al. Association between COVID-19 lockdown
measures and the incidence of iatrogenic versus spontaneous
very preterm births in the Netherlands: a retrospective study. BMC
Pregnancy Childbirth. 2021 Nov 12;21(1):767.
-
32. Hekimoğlu B, Aktürk Acar F. Effects of COVID-19 pandemic
period on neonatal mortality and morbidity. Pediatr Neonatol.
2022;63(1):78-83.
-
33. Indrio F, Salatto A, Amato O, Bartoli F, Capasso L, Corvaglia L,
et al. COVID-19 pandemic in the neonatal intensive care unit: any
effect on late-onset sepsis and necrotizing enterocolitis? Eur J Pediatr.
2022;181(2):853-857.
-
34. Palleri E, Svenningsson A, Markasz L, Engstrand Lilja H. The Incidence
of Necrotizing Enterocolitis and Late-Onset Sepsis during
the COVID-19 Pandemic in Sweden: A Population-Based Cohort
Study. Neonatology. 2024;121(3):336-341.