Relationships Between Post-Endoscopıc Retrograde Cholangiopancreatography Pancreatitis and Preoperative Laboratory Parameters

Abstract

Purpose: Investigation of the relationship between post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and laboratory tests performed before ERCP. Materials and Methods: ERCP procedures performed between March 2015 and June 2016 were analyzed retrospectively. Patient’s age, gender, ERCP indications, procedures performed during ERCP, complications after ERCP were determined. The relationship between post-ERCP pancreatitis and white blood cell, neutrophil, lymphocyte, hemoglobin, thrombocyte, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama-glutamly transferase (GGT), total bilirubin, albumin, lactate dehydrogenase (LDH) values of the patients before the procedure was investigated. Results: GGT and AST levels in the preoperative period were lower in patients with pancreatitis compared to those who did not (GGT p=0.001, AST p=0.006). No significant difference was found in other parameters. Conclusion: Post-ERCP pancreatitis is the most common complication of ERCP. Detection of patients with risk factors for the development of pancreatitis is important for early diagnosis and treatment. AST level lesser than 1.5 times normal value and GGT level lesser than 4 times can be used in pre-operative pancreatitis risk assessment.

Keywords

• pancreatitis
• post-ERCP
• risc factors

Endoskopik Retrograd Kolanjiopankreatografi Sonrası Pankreatit ile Preoperatif Dönemde Bakılan Laboratuar Parametrelerinin İlişkisi

Abstract

Amaç: Endoskopik retrograd kolanjiopankreatografi (ERCP) öncesinde bakılan laboratuar tetkikleri ile post-ERCP pankreatit ilişkisinin araştırılması. Araçlar ve Yöntem Mart 2015- Haziran 2016 tarihleri arasında yapılan ERCP işlemler retrospektif olarak incelendi. ERCP yapılan hastaların yaşı, cinsiyeti, ERCP endikasyonları, ERCP sırasında yapılan işlemler, işlem sonrası oluşan komplikasyonlar belirlendi. İşlem öncesinde hastaların beyaz küre, nötrofil, lenfosit, hemoglobin, trombosit, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), alkalen fosfataz (ALP), gama glutamil transferaz (GGT), total bilirubin, albumin, laktat dehidrogenaz (LDH) değerleriyle post-ERCP pankreatit ilişkisi araştırıldı. Bulgular: Hastaların işlem öncesi bakılan laboratuar parametrelerinden GGT ve AST seviyesi pankreatit geçiren hastalarda, geçirmeyenlere oranla düşüktü. (GGT p=0.001, AST p=0.006). Diğer parametrelerde ise anlamlı fark saptanılmadı. Sonuç: Post-ERCP pankreatit ERCP’nin en sık görülen komplikasyonudur. Pankreatit gelişimi açısından risk faktörleri bulunan hastaların tespiti erken tanı ve tedavi açısından önem taşımaktadır. AST düzeyinin normal üst sınırından 1.5 kat ve GGT düzeyinin 4 kattan düşük olması pre-operatif pankreatit risk değerlendirmesinde kullanılabilir.

Keywords

• pankreatit
• post-ERCP
• risk faktörü

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