Donör Yaşının Alıcı Greft Fonksiyonu Üzerine Etkisi

Abstract

Amaç: Son dönem böbrek hastalığı (SDBH) morbidite ve mortalitesi yüksek bir durumdur. Böbrek nakli bu durumun hasta açısından en çok tercih edilen ve en çok fayda sağlayan tedavi yöntemidir. Yaş, transplantasyonun başarısını etkileyebilecek önemli bir faktördür. Bu çalışmada donör yaşının böbrek nakli sonuçları üzerindeki etkisini araştırdık. Araçlar ve Yöntem: Bu çalışmaya canlı veya kadavradan böbrek nakli yapılmış 101 SDBH olan hasta retrospektif olarak incelendi. Vericilerin yaş, cinsiyet ve vücut kitle indeksi (VKİ) ve alıcıların yaş, cinsiyet, VKİ, hastanede yatış süreleri, tahmini glomerüler filtrasyon hızları (eGFR) ve serum kreatinin ölçümleri kaydedildi. Alıcı serum kreatinin seviyeleri, nakilden sonraki 18 aya kadar aralıklarla kaydedildi. Bulgular: Donörler yaşlarına göre (<40 yaş (n:42), 40-50 yaş (n:25) ve >50 yaş (n:34)) olmak üzere 3 gruba ayrıldı. Vericinin cinsiyeti, VKİ, canlı/kadavra oranı ve alıcının cinsiyeti, yaşı ve VKİ açısından istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Verici <40 yaş olan alıcıların hastanede kalış süreleri diğer yaş gruplarına göre istatistiksel olarak anlamlı derecede düşüktü ( p:0.001) 1. aydan 18. aya kadar donör yaşı arttıkça GFR'de istatistiksel olarak anlamlı azalma ve serum kreatinin değerinde artış gözlendi (p<0.05). Sonuç: Donör yaşı, greft sağkalımı için önemli bir faktördür ve organ dağıtım prosedürlerinde göz önünde bulundurulmalıdır.

Keywords

• yaşlanma
• donör
• greft sağkalımı

The Effect of Donor Age on Recipient Kidney Graft Function

Abstract

Purpose: End-stage renal disease (ESRD) is a highly morbid and mortal condition. Renal transplantation is the most favorable and preferred solution of this disease. Age is an important factor that can effects the success of transplantation. In this study, we investigated the effect of donor age on the outcomes of kidney transplantation. Materials and Methods: 101 ESRD patients who underwent live or cadaveric kidney transplantation were included and analyzed retrospectively in this study. We reviewed age, sex and body mass index (BMI) of the donors and age, sex, BMI, length of stay, estimated glomerular filtration rate (eGFR) and serum creatinine measurements of the recipients were recorded. Recipient serum creatinine levels were determined at intervals up to 18 months after transplantation. Results: Donors were divided into 3 groups according to age (<40 years (n:42), 40-50 years (n:25) and >50 years (n:34). There was no statistically significant difference between the groups in terms of donor's gender, BMI, living/cadaveric ratio, and recipient's gender, age, and BMI (p>0.05). Length of hospital stay of recipients whose donor <40 years old were statistically significantly lower compared to other age groups (p:0.001). From the 1st month to the 18th month, a statistically significant decrease in GFR and an increase in serum creatinine were observed as the donor age increased (p<0.05). Conclusion: Donor age is an important factor for the graft survival and for the allocation procedures it should be kept in mind.

Keywords

• ageing
• donor
• graft survival

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