Outcomes of Intravenous Thrombolytic Therapy in Acute Ischemic Stroke

Abstract

Purpose: In this study, we aimed to share our experiences about the efficacy, complications and prognosis of intravenous recombinant tissue plasminogen activator (iv rt-PA) in patients with acute ischaemic stroke in our stroke unit. Materials and Methods: Between September 2018 and December 2021, 39 patients who underwent iv rt-PA in our stroke unit were retrospectively analysed. Demographic characteristics, stroke risk factors, symptom-door, symptom-needle time, NIHSS (National Institutes of Health Stroke Scale) and MRS (Modified Rankin Scale) values of the patients were recorded from their files. Results: Twenty-two patients were female (56.4%) and 17 were male (43.6%). The most common risk factors were hypertension (56.4%) and hyperlipidemia (46.2%). NIHSS scores at admission, 24 h and day 7 were 17.3±5.9, 13.4±8.7, 11.1±10.3, respectively. Cerebral haemorrhage was detected in only 9 (23.1%) of the patients and death was detected in 12 (30.8%). Conclusion: Iv rt-PA treatment is an effective and safe method for acute ischemic stroke. Increasing public awareness and the number of stroke units and centers in stroke treatment will significantly improve success rates to much higher levels.

Keywords

• retrospective
• patient
• treatment success

Akut İskemik İnmede İntravenöz Trombolitik Tedavi Sonuçları

Abstract

Amaç: Bu çalışmada inme ünitemizde intravenöz rekombinan doku plazminojen aktivatörü (iv rt-PA) uyguladığımız akut iskemik inme tanılı hastaların verilerini inceleyerek tedavinin etkinliği, komplikasyonları ve prognozları hakkında deneyimlerimizi paylaşmayı amaçladık. Araçlar ve Yöntem: Eylül 2018 ve Aralık 2021 yılları arasında inme ünitemizde iv rt-PA uyguladığımız 39 hasta retrospektif olarak incelendi. Hastaların demografik özellikleri, inme risk faktörleri, semptom-kapı, semptom-iğne zamanı, NIHSS (National Institutes of Health Stroke Scale) ve MRS (Modified Rankin Scale) değerleri dosyalarından kaydedildi. Bulgular: Hastaların 22’sikadın (% 56.4),17’si erkekti (%43.6). En sık görülen risk faktörü hipertansiyon (%56.4) ve hiperlipidemiydi (%46.2). Hastaların giriş, 24. saat ve 7. gününde bakılan NIHSS skorları sırasıyla 17.3±5.9, 13.4±8.7, 11.1±10.3’idi. Hastaların sadece 9‘unda (%23.1) serebral kanama saptanırken, 12’sinde (%30.8) ölüm olduğu saptandı. Sonuç: Ivrt-PA tedavisi akut iskemik inmede etkili ve güvenli bir yöntemdir. İnme tedavisinde toplumsal farkındalığın artırılması, inme ünitesi ve merkezlerinin sayılarının artırılması ile başarı oranları çok daha iyi seviyelere yükselecektir.

Keywords

• hasta
• retrospektif
• tedavi başarısı

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