Araştırma Makalesi
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Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?

Yıl 2020, , 77 - 81, 12.12.2020
https://doi.org/10.46332/aemj.752709

Öz

Purpose: In this study, we aimed to evaluate the possible long-term effects of phlebotomy on body oxidant and antioxidant system in healthy people.


Materials and Methods: This prospective study included 30 healthy volunteers (15 men and 15 women) who applied to donate blood to the Red Crescent Blood Center. Total antioxidant capacity, total oxidant status, oxidative stress index, hemoglobin, unsaturated iron binding capacity, iron and ferritin levels were measured before the phlebotomy and on the 14th day following the procedure.


Results: The levels of total antioxidant capacity, total oxidant status, oxidative stress index, hemoglobin, unsaturated iron binding capacity, and iron values showed no statistically significant difference before and after the procedure (p> 0.05). Hemoglobin and ferritin values showed statistically significant difference before and after the procedure.


Conclusion: It seems that single-season phlebotomy has no long-term effect on the body total oxidant and antioxidant levels. 

Kaynakça

  • 1. Parapia LA. History of bloodletting by phlebotomy. Br J Haematol. 2008;143(4):490-495.
  • 2. Zivot A, Lipton JM, Narla A, Blanc L. Erythropoiesis: insights into pathophysiology and treatments in 2017. Mol Med. 2018;24(1):11.
  • 3. Rahal A, Kumar A, Singh V, et al. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014. Article ID:761264.
  • 4. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1-40.
  • 5. Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M. Targeting Free Radicals in Oxidative Stress-Related Human Diseases. Trends Pharmacol Sci 2017;38(7):592-607.
  • 6. Kattoor AJ, Pothineni NVK, Palagiri D, Mehta JL. Oxidative Stress in Atherosclerosis. Curr Atheroscler Rep. 2017;19(11):42.
  • 7. Salonen JT, Tuomainen TP, Salonen R, Lakka TA, Nyyssonen K. Donation of blood is associated with reduced risk of myocardial infarction. The Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Epidemiol. 1998;148(5):445-451.
  • 8. Zacharski LR, Chow BK, Howes PS, et al. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst. 2008;100(14):996-1002.
  • 9. Houschyar KS, Ludtke R, Dobos GJ, et al. Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial. BMC Med. 2012;10:54.
  • 10. Dwyer BE, Zacharski LR, Balestra DJ, et al. Getting the iron out: phlebotomy for Alzheimer's disease? Med Hypotheses. 2009;72(5):504-509.
  • 11. Durmus A, Mentese A, Yilmaz M, et al. The thrombotic events in polycythemia vera patients may be related to increased oxidative stress. Med Princ Pract. 2014;23(3):253-258.
  • 12. Yunce M, Erdamar H, Bayram NA, Gok S. One more health benefit of blood donation: reduces acute-phase reactants, oxidants and increases antioxidant capacity. J Basic Clin Physiol Pharmacol. 2016;27(6):653-657.
  • 13. Sposi NM. Oxidative Stress and Iron Overload in β-Thalassemia: An Overview. Zakaria M., editor. Beta Thalassemia. UK; IntechOpen;2019
  • 14. Kim KH, Oh KY. Clinical applications of therapeutic phlebotomy. J Blood Med. 2016;7:139-144.
  • 15. Cook LS. Therapeutic phlebotomy: a review of diagnoses and treatment considerations. J Infus Nurs. 2010;33(2):81-88.
  • 16. Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother. 2001;55(6):333-339.
  • 17. Yano M, Hayashi H, Wakusawa S, et al. Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C. Am J Gastroenterol. 2002;97(1):133-137.
  • 18. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta. 2009;1790(7):671-681.

Sağlıklı İnsanlarda Donör Amaçlı Yapılan Flebotominin Total Oksidan ve Total Antioksidan Düzeylere Etkisi Var mıdır?

Yıl 2020, , 77 - 81, 12.12.2020
https://doi.org/10.46332/aemj.752709

Öz

Amaç: Bu çalışmada, sağlıklı kişilerde yapılan flebotomi işleminin uzun dönemde vücut oksidan ve antioksidan sistem üzerindeki olası etkilerinin değerlendirilmesi amaçlanmıştır.


Araçlar ve Yöntem: Bu çalışma prospektif olarak tasarlanmış olup, çalışmaya Kızılay Kan Merkezine donör amaçlı kan bağışında bulunmak için başvuran sağlıklı ve gönüllü 30 kişi (15 erkek 15 kadın) dâhil edilmiştir. Flebotomi işlemi öncesinde ve işlemden sonraki 14. günde total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi, hemoglobin, doymamış demir baglama kapasitesi, demir ve ferritin düzeyleri ölçüldü.


Bulgular: İşlem öncesi ve işlemden sonraki 14. günde total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi, hemoglobin, doymamış demir baglama kapasitesi ve demir değerleri istatistiksel olarak anlamlı değildi (p>0.05). İşlemden önceki hemoglobin ve ferritin değerleri ile 14. gündeki değerler anlamlı bulundu (p<0.001).


Sonuç: Tek defa yapılan flebotomi işleminin uzun dönemde vücut total oksidan ve total antioksidan düzeylerine etkisinin olmadığı görünmektedir.

Kaynakça

  • 1. Parapia LA. History of bloodletting by phlebotomy. Br J Haematol. 2008;143(4):490-495.
  • 2. Zivot A, Lipton JM, Narla A, Blanc L. Erythropoiesis: insights into pathophysiology and treatments in 2017. Mol Med. 2018;24(1):11.
  • 3. Rahal A, Kumar A, Singh V, et al. Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int. 2014. Article ID:761264.
  • 4. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1-40.
  • 5. Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M. Targeting Free Radicals in Oxidative Stress-Related Human Diseases. Trends Pharmacol Sci 2017;38(7):592-607.
  • 6. Kattoor AJ, Pothineni NVK, Palagiri D, Mehta JL. Oxidative Stress in Atherosclerosis. Curr Atheroscler Rep. 2017;19(11):42.
  • 7. Salonen JT, Tuomainen TP, Salonen R, Lakka TA, Nyyssonen K. Donation of blood is associated with reduced risk of myocardial infarction. The Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Epidemiol. 1998;148(5):445-451.
  • 8. Zacharski LR, Chow BK, Howes PS, et al. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst. 2008;100(14):996-1002.
  • 9. Houschyar KS, Ludtke R, Dobos GJ, et al. Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial. BMC Med. 2012;10:54.
  • 10. Dwyer BE, Zacharski LR, Balestra DJ, et al. Getting the iron out: phlebotomy for Alzheimer's disease? Med Hypotheses. 2009;72(5):504-509.
  • 11. Durmus A, Mentese A, Yilmaz M, et al. The thrombotic events in polycythemia vera patients may be related to increased oxidative stress. Med Princ Pract. 2014;23(3):253-258.
  • 12. Yunce M, Erdamar H, Bayram NA, Gok S. One more health benefit of blood donation: reduces acute-phase reactants, oxidants and increases antioxidant capacity. J Basic Clin Physiol Pharmacol. 2016;27(6):653-657.
  • 13. Sposi NM. Oxidative Stress and Iron Overload in β-Thalassemia: An Overview. Zakaria M., editor. Beta Thalassemia. UK; IntechOpen;2019
  • 14. Kim KH, Oh KY. Clinical applications of therapeutic phlebotomy. J Blood Med. 2016;7:139-144.
  • 15. Cook LS. Therapeutic phlebotomy: a review of diagnoses and treatment considerations. J Infus Nurs. 2010;33(2):81-88.
  • 16. Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother. 2001;55(6):333-339.
  • 17. Yano M, Hayashi H, Wakusawa S, et al. Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C. Am J Gastroenterol. 2002;97(1):133-137.
  • 18. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta. 2009;1790(7):671-681.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Bilimsel Araştırma Makaleleri
Yazarlar

Kenan Güçlü 0000-0002-0092-652X

Hasan Esat Yücel 0000-0001-7788-0227

Yayımlanma Tarihi 12 Aralık 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Güçlü, K., & Yücel, H. E. (2020). Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?. Ahi Evran Medical Journal, 4(3), 77-81. https://doi.org/10.46332/aemj.752709
AMA Güçlü K, Yücel HE. Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?. Ahi Evran Med J. Aralık 2020;4(3):77-81. doi:10.46332/aemj.752709
Chicago Güçlü, Kenan, ve Hasan Esat Yücel. “Does Phlebotomy for Donor Purposes in Healthy People Have Effects on Total Oxidant and Total Antioxidant Levels?”. Ahi Evran Medical Journal 4, sy. 3 (Aralık 2020): 77-81. https://doi.org/10.46332/aemj.752709.
EndNote Güçlü K, Yücel HE (01 Aralık 2020) Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?. Ahi Evran Medical Journal 4 3 77–81.
IEEE K. Güçlü ve H. E. Yücel, “Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?”, Ahi Evran Med J, c. 4, sy. 3, ss. 77–81, 2020, doi: 10.46332/aemj.752709.
ISNAD Güçlü, Kenan - Yücel, Hasan Esat. “Does Phlebotomy for Donor Purposes in Healthy People Have Effects on Total Oxidant and Total Antioxidant Levels?”. Ahi Evran Medical Journal 4/3 (Aralık 2020), 77-81. https://doi.org/10.46332/aemj.752709.
JAMA Güçlü K, Yücel HE. Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?. Ahi Evran Med J. 2020;4:77–81.
MLA Güçlü, Kenan ve Hasan Esat Yücel. “Does Phlebotomy for Donor Purposes in Healthy People Have Effects on Total Oxidant and Total Antioxidant Levels?”. Ahi Evran Medical Journal, c. 4, sy. 3, 2020, ss. 77-81, doi:10.46332/aemj.752709.
Vancouver Güçlü K, Yücel HE. Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?. Ahi Evran Med J. 2020;4(3):77-81.

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