45,X[75]/46,Xdel(X)(p11.2)[25] Karyotipine sahip unikornuat uteruslu olgu

Yıl 2019, Cilt: 3 Sayı: 1, 31 - 33, 28.04.2019

Recep Eröz , Mehmet Köksal , Mustafa Doğan , Hüseyin Yüce , Alper Başbuğ

Öz

Turner sendromu, önemli bir
infertilite nedenidir ancak mozaik veya X
delesyonu taşıyan hastalarda eğer puberteye spontan olarak girilmişse gebelik
gerçekleşebilmektedir. Unikornuat
uterus ise gebelik kaybına yol açabilen ve çok nadir rastlanılan bir uterus anomalisidir.
Şu anki olgu, nadir görülmesi ve Turner sendromlu
hastalarda gebelik kayıplarının bir nedenin ortaya konması gibi yönleriyle
literatüre katkı sağlamak amacıyla sunulmuştur.

Anahtar Kelimeler

Habitual abortus, Turner Sendromu, Unikornuat, X kromozomu mosaizmi

A case with 45,X[75]/46,Xdel(X)(p11.2)[25] unicornuate uterus

Öz

Turner syndrome is a major cause of infertility, but
pregnancy can occur in cases with the mosaic or X-defect who spontaneously enter
puberty. Unicornuate uterus is the rarest uterine anomaly that can lead to loss
of pregnancy. The current case is presented because she is rare and a cause of
pregnancy loss in patients with Turner's syndrome for the contribution to the
literature.

Anahtar Kelimeler

Habitual abortus, Turner syndrome, Unicornuate, X chromosome mosaicism

Kaynakça

• 1. Stochholm K, Juul S, Juel K, Naeraa RW, Gravholt CH. Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome. J Clin Endocrinol Metab. 2006; 91:3897–3902. [PubMed: 16849410] https://www.ncbi.nlm.nih.gov/pubmed/16849410
• 2. Nussbaum, R.L.,Mclnnes, R.R., Willard, H.F.: Thompson&Thompson Genetics in Medicine, 6th Ed, Saunders, Phledelphia, 2005: 174-176. https://www.ncbi.nlm.nih.gov/nlmcatalog/101653590
• 3. Verschraegen-Spae MR, Depypere H, Speleman F, Dhondt M, De Paepe. Familial Turner syndrome. Clin Genet 1992;41(4): 218-20. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0004.1992.tb03666.x
• 4. Lemli L, Smith DW. The XO syndrome: A study of the differentiated phenotype in 25 patients. J Pediatr 1963; 63(Oct):577-88. https://www.sciencedirect.com/science/article/pii/S0022347663803686?via%3Dihub
• 5. Morgan T.;Turner Syndrome: Diagnosis and Management. Am Fam Physician. 2007; 76(3):405-417.
• 6. Al Sheikh M, Dunger DB, Conway GS, Wass JAH. Turner’s syndrome in Adulthood Endocr Rev 2002; 23:120–140.
• 7. Speroff L, Glass RH, Kase NG. Clinical Gynecologic Endocrinology and Infertility. 6th ed. Baltimore: Lippincott Williams & Wilkins; 1999: 123-58.