The appropriate use of proton pump inhibitors: Single centre experience

Öz

Bacground and Aims: Proton pump inhibitors are a class of pharmaceuticals that effectively inhibit gastric acid secretion. Their utilisation is increasing on a global scale. However, the use of proton pump inhibitors for off-label and unnecessary indications has also increased significantly. The aim of this study was to evaluate the appropriateness of proton pump inhibitor use. Materials and Methods: This study was conducted as a single-centre, cross-sectional observational study. Between 10 March 2022 and 10 April 2022, patients admitted to the Gastroenterology Clinic of Mersin University Faculty of Medicine were examined. The reasons for hospitalisation, demographic data, and pre- and post-hospitalisation drug use of the patients were recorded without the clinical team being aware of the study. Results: During the study period, 106 patients were hospitalised in the clinic, with 53% of the patients being male and the mean age being 65.8 years. The most common reasons for hospitalisation were gastrointestinal bleeding, acute pancreatitis and abdominal pain. While 45 (42%) of the hospitalised patients used proton pump inhibitors at home, 24 (53%) of them had appropriate indication. Of the 92 (86.7%) patients who used proton pump inhibitors during hospitalisation, 41 (44.6%) had appropriate indication. Conclusion: Proton pump inhibitors represent a class of pharmaceutical agents commonly prescribed for the management of acid-related pathologies, characterised by their favourable safety profile and broad accessibility. However, this widespread utilisation carries inherent risks, including the potential for inappropriate prescriptions. It is imperative to underscore the significance of potential drawbacks, such as adverse effects of a minor severity, financial implications and the necessity for polypharmacy, as highlighted in extant research.

Anahtar Kelimeler

• Drug misuse
• prophylaxis
• proton pump inhibitors
• GERD

Proton pompa inhibitörlerini ne kadar doğru kullanıyoruz? Tek merkez deneyimi

Öz

Giriş ve Amaç: Proton pompa inhibitörleri, gastrik asit sekresyonunu etkili bir şekilde bloke eden ilaçlardır. Tüm dünyada kullanımları artmaktadır. Bununla birlikte, gereksiz ve endikasyon dışı proton pompa inhibitörü kullanımının da ciddi şekilde arttığı gözlemlenmektedir. Bu çalışmanın amacı, proton pompa inhibitörleri kullanımının uygunluğunu değerlendirmektir. Gereç ve Yöntem: Bu çalışma, tek merkezli ve kesitsel bir gözlem çalışması olarak gerçekleştirilmiştir. 10 Mart 2022- 10 Nisan 2022 tarihleri arasında Mersin Üniversitesi Tıp Fakültesi Gastroenteroloji Kliniğine yatırılan hastalar incelendi. Hastaların yatış nedenleri, demografik verileri, yatış öncesi ve sonrası ilaç kullanımları klinik ekibi çalışmanın farkında olmadan kaydedildi. Bulgular: Çalışma döneminde 106 hasta kliniğe yatırıldı. Hastaların %53'ü erkek olup, yaş ortalaması 65.8 yıl idi. Yatış nedenleri arasında en sık görülenler gastrointestinal sistem kanaması, akut pankreatit ve karın ağrısı etiyolojisi araştırılması olarak belirlendi. Yatan hastaların 45’i (%42) evde proton pompa inhibitörleri kullanırken bunların 24’ünde (%53) uygun endikasyon vardı. Hastanede yatış sırasında proton pompa inhibitörleri kullanan 92 (%86.7) hastanın ise 41’inde (%44.6) proton pompa inhibitörleri kullanımı endikasyona uygundu. Sonuç: Proton pompa inhibitörleri asit ile ilişkili hastalıkların tedavisinde temel ilaçlar arasında yer almakta ve düşük yan etki profilleri sayesinde yaygın olarak kullanılmaktadır. Ancak, bu durum gereksiz kullanım riskini de beraberinde getirmektedir. Az da olsa ciddi yan etkiler, mali yük ve polifarmasi gibi dezavantajların önemi çalışmalar ile vurgulanmalıdır.

Anahtar Kelimeler

• Profilaksi
• proton pompası inhibitörleri
• uygunsuz ilaç kullanımı
• GERH

Kaynakça

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