Araştırma Makalesi

Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool

Cilt: 24 Sayı: 1 29 Nisan 2025
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Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool

Öz

Background and Aims: Fecal occult blood test is frequently used as a first-line screening method for colorectal cancer. In addition to fecal occult blood test, other screening methods include fecal immunohistochemical test, sigmoidoscopy, and colonoscopy. This study aims to evaluate the colonoscopy and histopathology results of patients who underwent colonoscopy due to a positive fecal occult blood test. Materials and Methods: This study included patients who underwent colonoscopy due to a positive fecal occult blood test at Antalya Training and Research Hospital between January 2020 and December 2024. Patients with inadequate bowel preparation, a known history of colorectal cancer, or inflammatory bowel disease were excluded. The age, gender, colonoscopy findings, and histopathological results of the included patients were recorded. Results: A total of 508 patients were included in the study, of whom 260 (51.2%) were male and 248 (48.8%) were female, with a median age of 61 years (range: 20 - 95). The median hemoglobin level was 13.5 g/dL (range: 5 - 16.3). Colonoscopy findings were normal in 196 (38.6%) patients. Other findings included polyps in 107 (21.1%), inflammatory bowel disease in 70 (13.8%), perianal disease in 59 (11.6%), colorectal cancer in 31 (6.1%), diverticula in 26 (5.1%), ulcers in 15 (3%), and angiodysplasia in 4 (0.8%) patients. A total of 223 (43.8%) patients with suspected colorectal cancer or polyps underwent biopsy. Histopathological examination revealed adenomatous polyps in 77 (34.5%) patients, inflammatory bowel disease in 59 (26.5%), adenocarcinoma in 31 (13.9%), and hyperplastic polyps in 26 (11.7%) patients, while 30 (13.5%) patients had no pathological findings. Conclusion: Nearly half of the patients who underwent colonoscopy due to a positive fecal occult blood test were found to have colonic pathology. Fecal occult blood test is a simple, cost-effective, and practical test not only for detecting colorectal cancer and precancerous lesions but also for identifying other colonic pathologies such as inflammatory bowel disease, diverticula, and perianal diseases.

Anahtar Kelimeler

Kaynakça

  1. 1) Maida M, Macaluso FS, Ianiro G, et al. Screening of colorectal cancer: present and future. Expert Rev Anticancer Ther 2017;17(12):1131-46.
  2. 2) Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-63.
  3. 3) Carroll MR, Seaman HE, Halloran SP. Tests and investigations for colorectal cancer screening. Clin Biochem. 2014;47(10-11):921-39.
  4. 4) Bond JH. Fecal occult blood test screening for colorectal cancer. Gastrointest Endosc Clin N Am. 2002;12(1):11-21.
  5. 5) Kahi CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality. Clin Gastroenterol Hepatol. 2009;7(7):770-5;quiz 711.
  6. 6) van Rossum LG, van Rijn AF, Laheij RJ, et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology. 2008;135(1):82-90.
  7. 7) Yang H, Ge Z, Dai J, Li X, Gao Y. Effectiveness of the immunofecal occult blood test for colorectal cancer screening in a large population. Dig Dis Sci. 2011;56(1):203-7.
  8. 8) Zouridis S, Sofia D, Alshakhatreh O, et al. Do You Bleed? A 1-Year FOBT Case-Series Study. J Clin Gastroenterol. 2024 Apr 29. Epub ahead of print. PMID: 38668714.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Gastroenteroloji ve Hepatoloji

Bölüm

Araştırma Makalesi

Yayımlanma Tarihi

29 Nisan 2025

Gönderilme Tarihi

24 Şubat 2025

Kabul Tarihi

11 Nisan 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 24 Sayı: 1

Kaynak Göster

APA
Köker, G., Kocabıyık, A. B., Eren Durmuş, M., Coşkuner, M. A., Zorlu Görgülügil, G., Koç, L. Z., Şahintürk, Y., Başgöz, B. B., Akça, S., & Çekin, A. H. (2025). Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool. Akademik Gastroenteroloji Dergisi, 24(1), 9-14. https://doi.org/10.17941/agd.1684092
AMA
1.Köker G, Kocabıyık AB, Eren Durmuş M, vd. Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool. Akademik Gastroenteroloji Dergisi. 2025;24(1):9-14. doi:10.17941/agd.1684092
Chicago
Köker, Gökhan, Alperen Burak Kocabıyık, Merve Eren Durmuş, vd. 2025. “Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool”. Akademik Gastroenteroloji Dergisi 24 (1): 9-14. https://doi.org/10.17941/agd.1684092.
EndNote
Köker G, Kocabıyık AB, Eren Durmuş M, Coşkuner MA, Zorlu Görgülügil G, Koç LZ, Şahintürk Y, Başgöz BB, Akça S, Çekin AH (01 Nisan 2025) Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool. Akademik Gastroenteroloji Dergisi 24 1 9–14.
IEEE
[1]G. Köker vd., “Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool”, Akademik Gastroenteroloji Dergisi, c. 24, sy 1, ss. 9–14, Nis. 2025, doi: 10.17941/agd.1684092.
ISNAD
Köker, Gökhan - Kocabıyık, Alperen Burak - Eren Durmuş, Merve - Coşkuner, Muhammed Ali - Zorlu Görgülügil, Gizem - Koç, Lütfullah Zahit - Şahintürk, Yasin - Başgöz, Bilgin Bahadır - Akça, Serdar - Çekin, Ayhan Hilmi. “Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool”. Akademik Gastroenteroloji Dergisi 24/1 (01 Nisan 2025): 9-14. https://doi.org/10.17941/agd.1684092.
JAMA
1.Köker G, Kocabıyık AB, Eren Durmuş M, Coşkuner MA, Zorlu Görgülügil G, Koç LZ, Şahintürk Y, Başgöz BB, Akça S, Çekin AH. Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool. Akademik Gastroenteroloji Dergisi. 2025;24:9–14.
MLA
Köker, Gökhan, vd. “Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool”. Akademik Gastroenteroloji Dergisi, c. 24, sy 1, Nisan 2025, ss. 9-14, doi:10.17941/agd.1684092.
Vancouver
1.Gökhan Köker, Alperen Burak Kocabıyık, Merve Eren Durmuş, Muhammed Ali Coşkuner, Gizem Zorlu Görgülügil, Lütfullah Zahit Koç, Yasin Şahintürk, Bilgin Bahadır Başgöz, Serdar Akça, Ayhan Hilmi Çekin. Evaluation of colonoscopy and histopathology results in patients undergoing colonoscopy for occult blood positivity in stool. Akademik Gastroenteroloji Dergisi. 01 Nisan 2025;24(1):9-14. doi:10.17941/agd.1684092